Siv Jönsson

Researcher at Department of Pharmacy, Pharmacometrics

Email:
siv.jonsson[AT-sign]farmbio.uu.se
Telephone:
+46-72 9999316
Visiting address:
Room BMC B3:4 Biomedicinskt Centrum BMC, Husargatan 3
752 37 Uppsala
Postal address:
Box 580
751 23 UPPSALA

Researcher at Department of Pharmacy, Pharmacometrics

Email:
siv.jonsson[AT-sign]farmaci.uu.se
Visiting address:
Biomedicinskt Centrum BMC, Husargatan 3
752 37 Uppsala
Postal address:
Box 580
751 23 UPPSALA

Short presentation

I am a researcher in the Pharmacometrics group and work with non-linear mixed effects models, i.e. mathematical models i) describing how concentrations and effects of medicines change over time and vary between patients and ii) used in optimizing drug therapy and drug development.

I work with Mats Karlsson and Elisabet Nielsen in projects related to hemophilia and biologic medicinal products and also in a European project, U-PGx, addressing the value of pharmacogenomic testing in patient care.

Keywords: non-linear mixed effects modelling nonmem pharmacokinetics pharmacometrics pharmacodynamics

Dr Siv Jönsson is a senior researcher in the Pharmacometric group within the Department of Pharmacy, Uppsala University, Sweden, headed by Professor Mats O Karlsson. Siv earned an MSc degree in 1988 and has thereafter been working in the pharmacokinetic, pharmacodynamic and pharmacometric areas in three environments: the pharmaceutical industry, the regulatory agency and in academia.

In total 5 years were spent within industry (Kabi Pharmacia, Astra Zeneca) working with clinical pharmacology and pharmacometrics. Furthermore, Siv worked as a pharmacokinetic assessor within the Swedish regulatory authority (Medical Products Agency) in 2 periods (in total 9 years, latest period 2007-2011). Finally, the academic years include her PhD education (PhD obtained in 2004), 2 years as senior lecturer and 6 years as researcher; all these years dealing with methodological and applied pharmacometric projects, where applied projects relate to e.g. renal transplant patients and haemophilia A/B patients.

Siv has published approximately 35 peer-reviewed research articles and book chapters and is currently the co-supervisor of 2 PhD students.

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Siv Jönsson