Sandra Kleinau
Professor at Institutionen för cell- och molekylärbiologi; Mikrobiologi och immunologi
- Telephone:
- +46 18 471 40 61
- E-mail:
- Sandra.Kleinau@icm.uu.se
- Visiting address:
- Husargatan 3
752 37 Uppsala - Postal address:
- Box 596
751 24 Uppsala
More information is available to staff who log in.
Short presentation
Dr. Sandra Kleinau is a professor of molecular immunology and is interested in the function of the immune system. Immune cells protect us from infectious agents and keep us healthy. But why do they sometimes start to attack the body's own tissue, such as in an autoimmune disease? Can we learn from this misdirected attack to find a cure and at the same time develop an immunotherapy that kills cancerous cells? Answering these questions is what drives the lab´s work.
Keywords
- antibodies
- autoimmunity
- b lymphocytes
- chronic inflammation
- fc receptors
- immunobiology
- immunology
- immunotherapy
- macrophages
- monocytes
- rheumatoid arthritis
Biography
Professor in biology; molecular immunology, Uppsala University (UU) (2008-)
Senior lecturer in biology; molecular immunology, UU (2004-2008)
Senior researcher, Göran Gustafsson's Foundation, UU (2001-2003)
Associate professor in experimental pathology, UU (1999)
Assistent professor, UU (1997-2000)
Postdoc, UU (1996-1997)
Postdoc, Karolinska Institute (1994-1995)
PhD in clinical immunology, UU (1993)
BSc, UU (1989)
Publications
Selection of publications
- Proteolysis Breaks Tolerance toward Intact alpha 345(IV) Collagen, Eliciting Novel Anti-Glomerular Basement Membrane Autoantibodies Specific for alpha 345NC1 Hexamers (2013)
- Up Regulated Complement and Fc Receptors in Juvenile Idiopathic Arthritis and Correlation with Disease Phenotype (2012)
- Murine Membranous Nephropathy (2012)
- Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis (2011)
- FcgammaRIII-expressing macrophages are essential for development of collagen-induced arthritis. (2006)
- IgG immune complex-binding in macrophages from arthritis-susceptible and arthritis-resistant mice following collagen type II immunization. (2006)
- IgG Fc receptor polymorphisms and association with autoimmune disease. (2005)
- Gene targeting by ribozyme against TNF-alpha mRNA inhibits autoimmune arthritis. (2005)
- The impact of Fc receptors on the development of autoimmune diseases. (2003)
- Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB. (2003)
- Human problems - animal models: Aspects on the use of inducible experimental arthritis for pathogenetic studies of human inflammatory joint disease (1995)
Recent publications
- Impact of Fc receptors and host characteristics on myeloid phagocytic response to rituximab-treated 3D-cultured B-cell lymphoma (2023)
- The Human Monocyte (2022)
- Exploring complement-dependent cytotoxicity by rituximab isotypes in 2D and 3D-cultured B-cell lymphoma (2022)
- Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems (2022)
- Importance of antibody isotypes in antitumor immunity by monocytes and complement using human-immune tumor models (2021)
All publications
Articles
- Impact of Fc receptors and host characteristics on myeloid phagocytic response to rituximab-treated 3D-cultured B-cell lymphoma (2023)
- The Human Monocyte (2022)
- Exploring complement-dependent cytotoxicity by rituximab isotypes in 2D and 3D-cultured B-cell lymphoma (2022)
- Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems (2022)
- Importance of antibody isotypes in antitumor immunity by monocytes and complement using human-immune tumor models (2021)
- Marginal zone B cells (2021)
- On The Relationship between Rheumatoid Factors, Monocyte Subsets and FC Receptor Function in Early Ra (2016)
- Identification of self-reactive marginal-zone B cell like cells in lymph nodes of mice (2016)
- Nodal marginal zone B cells in mice (2016)
- Activated mast cells promote differentiation of B cells into effector cells (2016)
- Up-regulation of CD64-expressing monocytes with impaired Fc gamma R function reflects disease activity in polyarticular psoriatic arthritis (2015)
- Elevated Membrane and Soluble CD64 (2015)
- Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis (2015)
- Dysregulated Fc receptor function in active rheumatoid arthritis (2014)
- Identification of a Population of Lymph Node Marginal Zone B Cells that Expand in Mice Developing Autoimmune Arthritis (2014)
- Evidence of Marginal Zone B Cells in the Lymph Nodes Presenting Autoantigen to T Cells in a Model of Autoimmune Arthritis (2014)
- AB0102 Effects of anti-rheumatic treatment on antibody levels and monocytic fc receptor status in early ra (2013)
- Proteolysis Breaks Tolerance toward Intact alpha 345(IV) Collagen, Eliciting Novel Anti-Glomerular Basement Membrane Autoantibodies Specific for alpha 345NC1 Hexamers (2013)
- Expansion of a marginal zone B cell-like population in lymph nodes of mice developing collagen-induced arthritis (2013)
- Marginal zone B cells in autoimmune arthritis (2012)
- Molecular Basis for T Cell Response Induced by Altered Peptide Ligand of Type II Collagen (2012)
- Up Regulated Complement and Fc Receptors in Juvenile Idiopathic Arthritis and Correlation with Disease Phenotype (2012)
- Murine Membranous Nephropathy (2012)
- Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis (2011)
- T Cells Stimulated With an Analog Peptide of Type II Collagen Require the Fc Receptor gamma-Chain to Secrete Interleukin-4 and Suppress Autoimmune Arthritis in Mice (2011)
- Enhanced susceptibility to low-dose collagen-induced arthritis in CR1/2-deficient female mice (2009)
- Amelioration of collagen-induced arthritis by human recombinant soluble FcγRIIb (2008)
- The effect of activating and inhibiting Fc-receptors on murine mercury-induced autoimmunity. (2008)
- FcgammaRIII-expressing macrophages are essential for development of collagen-induced arthritis. (2006)
- IgG immune complex-binding in macrophages from arthritis-susceptible and arthritis-resistant mice following collagen type II immunization. (2006)
- IgG Fc receptor polymorphisms and association with autoimmune disease. (2005)
- Gene targeting by ribozyme against TNF-alpha mRNA inhibits autoimmune arthritis. (2005)
- The impact of Fc receptors on the development of autoimmune diseases. (2003)
- Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB. (2003)
- Activated mast cells promote a pro-inflammatory phenotype of B cells
Chapters
