Birgitta Heyman
Professor at Institutionen för medicinsk biokemi och mikrobiologi; Infektioner och immunitet; Jenny Hallgren Martinsson
- Telephone:
- +46 18 471 44 45
- Mobile phone:
- +46 70 720 42 75
- E-mail:
- birgitta.heyman@imbim.uu.se
- Visiting address:
- BMC
Husargatan 3
752 37 UPPSALA - Postal address:
- Box 582
751 23 UPPSALA
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Short presentation
I'm a professor at the Department of Medical Biochemistry and Microbiology, and specialized in Immunology. My research aims at understanding how antibodies up- and downregulate the immune response. This involves research on B lymphocytes, follicular dendritic cells (FDCs), complement, and Fc-receptors. The lab currently consists of two postdoctoral fellows and one research engineer.
Keywords
- antibodies
- b lymphocytes
- complement
- fc receptors
- follicular dendritic cells
- immunology
- immunotherapy
Publications
Recent publications
- Endogenous complement-activating IgM is not required for primary antibody responses but promotes plasma cell differentiation and secondary antibody responses to a large particulate antigen in mice (2024)
- A Novel Image Analysis Approach Reveals a Role for Complement Receptors 1 and 2 in Follicular Dendritic Cell Organization in Germinal Centers (2021)
- IgG Suppresses Antibody Responses to Sheep Red Blood Cells in Double Knock-Out Mice Lacking Complement Factor C3 and Activating Fc gamma-Receptors (2020)
- Regulation of Humoral Immune Responses and B Cell Tolerance by the IgM Fc Receptor (FcμR) (2020)
- IgG-mediated suppression of antibody responses (2020)
All publications
Articles
- Endogenous complement-activating IgM is not required for primary antibody responses but promotes plasma cell differentiation and secondary antibody responses to a large particulate antigen in mice (2024)
- A Novel Image Analysis Approach Reveals a Role for Complement Receptors 1 and 2 in Follicular Dendritic Cell Organization in Germinal Centers (2021)
- IgG Suppresses Antibody Responses to Sheep Red Blood Cells in Double Knock-Out Mice Lacking Complement Factor C3 and Activating Fc gamma-Receptors (2020)
- IgG-mediated suppression of antibody responses (2020)
- Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons (2019)
- IgG-mediated immune suppression in mice is epitope specific except during high epitope density conditions (2018)
- Mice Immunized With IgG Anti-Sheep Red Blood Cells (SRBC) Together With SRBC Have a Suppressed Anti-SRBC Antibody Response but Generate Germinal Centers and Anti-IgG Antibodies in Response to the Passively Administered IgG (2017)
- Epitope-Specific Suppression of IgG Responses by Passively Administered Specific IgG (2017)
- IgM is Unable to Enhance Antibody Responses in Mice Lacking C1q or C3 (2017)
- IgG3-antigen complexes are deposited on follicular dendritic cells in the presence of C1q and C3 (2017)
- IgE-mediated enhancement of CD4(+) T cell responses requires antigen presentation by CD8 alpha(-) conventional dendritic cells (2016)
- IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors. (2015)
- Enhancement of antibody responses by endogenous (complement activating) IgM (2015)
- Antigen Conjugated to Anti-CD23 Antibodies is Rapidly Transported to Splenic Follicles by Recirculating B Cells (2015)
- Antigen-Specific IgM Causes Deposition of C3 on Sheep Red Blood Cells Within Seconds After Immunization (2014)
- IgG-Mediated Suppression of Primary IgG Anti-SRBC Responses is not Dependent on Fc gamma R or Complement (2014)
- IgG-mediated Immune Suppression (2014)
- Prospective Isolation of Committed Mast Cell Progenitors from Mouse Blood (2014)
- Divergent Regulation of B and T Cell Responses by Complement-Activating IgM (2014)
- The Role of CD23 Expression on Follicular Dendritic Cells in IgE-mediated Enhancement (2014)
- IgG3-mediated enhancement of antibody responses is dependent on expression of complement receptors 1 and 2 (2014)
- B Cell-mediated Antigen Transport to Splenic Follicles (2014)
- Antigen Transfer from Exosomes to Dendritic Cells as an Explanation for the Immune Enhancement Seen by IgE Immune Complexes (2014)
- Enhancement of Antibody Responses by Endogenous IgM (2014)
- How antibodies use complement to regulate antibody responses (2014)
- Anti-CD23-Antigen Conjugates Localize Antigen to Splenic Follicles and Enhance Specific Ab Response (2014)
- Anti-CD23-antigen Conjugates Localize Antigen to Splenic Follicles and Enhance Specific Ab Response (2014)
- MZ B Cells Transport IgG3-Ag to Splenic Follicles and Induce Germinal Centres (2014)
- Marginal-zone B cells transport IgG3-antigen immune complexes into splenic B cell follicles (2014)
- Marginal Zone B Cells Transport IgG3-Immune Complexes to Splenic Follicles (2014)
- MZ B Cells Transport IgG3-Ag to Splenic Follicles and Induce Germinal Centers (2014)
- Committed mast cell progenitors in mouse blood differ in maturity between Th1 and Th2 strains (2013)
- Identification of committed mast cell progenitors in mouse blood (2013)
- Complement-Activating IgM Enhances the Humoral but Not the T Cell Immune Response in Mice (2013)
- IgE enhances B cell-derived exosomal induced T cell proliferation (2013)
- CD11c(+) Cells Are Required for Antigen-Induced Increase of Mast Cells in the Lung (2012)
- IgM-mediated enhancement of immune responses (2012)
- Complement receptors 1 and 2 in murine antibody responses to IgM-complexed and uncomplexed sheep erythrocytes (2012)
- IgE Immune Complexes Stimulate an Increase in Lung Mast Cell Progenitors in a Mouse Model of Allergic Airway Inflammation (2011)
- Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells (2011)
- IgE-Mediated Enhancement of CD4(+) T Cell Responses in Mice Requires Antigen Presentation by CD11c(+) Cells and Not by B Cells (2011)
- Requirement for complement in antibody responses is not explained by the classic pathway activator IgM (2011)
- Complement drives Th17 cell differentiation and triggers autoimmune arthritis (2010)
- Impaired antibody responses but normal proliferation of CD4+ T cells in mice lacking complement receptors 1 and 2 (2009)
- Studies on the mechanism by which antigen-specific IgG suppresses primary antibody responses (2009)
- A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen. (2008)
- IgE enhances specific antibody and T cell responses in mice overexpressing CD23 (2007)
- Antibody-mediated regulation of the immune response (2006)
- How antibodies act as natural adjuvants. (2005)
- IgE enhances antibody and T cell responses in vivo via CD23+ B cells (2005)
- IgE enhances antibody and T cell responses in vivo via CD23+ B cells. (2005)
- Antibody feedback inhibition - a biological principle of immune regulation (2005)
- IgG3-mediated enhancement of the antibody response is normal in Fc gammaRI-deficient mice (2005)
- IgG3-mediated enhancement of the antibody response is normal in Fc gammaRI-deficient mice (2005)
- IgG3-Mediated Enhancement of the Antibody Response is Normal in FcγRI-Deficient Mice (2005)
- IgG2a-mediated enhancement of antibody and T cell responses and its relation to inhibitory and activating Fcγ receptors (2004)
- FcγRIIB in IgG-mediated suppression of antibody responses (2001)
- Immunoglobulin-secreting cells of maternal origin can be detected in Bcell-deficient mice. (2000)
- Importance of CD23 for collagen-induced arthritis (1999)
- IgE enhances antibody responses and T cell activation in vivo
- Follicular B cells capture IgE-immune complexes and mediate activation of naïve T cells
- IgG3-Antigen Complexes Are Deposited on Follicular Dendritic Cells in the Presence of C1q and C3
- Mice Producing IgM Unable to Activate Complement Have Impaired Endogenous Feedback Regulation but Increased Antigen Trapping in Follicles
Chapters
