professor emeritus at Department of Pharmaceutical Biosciences, Research; Drug Safety and Toxicology
Eva Brittebo is a professor in Pharmaceutical toxicology. Previously she was the Head of the Department of Pharmaceutical Biosciences and an Adviser to the Vice-Chancellor on the PhD education at Uppsala University. Her main research interest is to study mechanisms of harmful effects of toxicants and pharmaceuticals in various experimental systems in vivo and in vitro. She has developed novel on-line courses in drug safety and pharmacovigilance.
Keywords: environmental pollutants toxicology pharmaceuticals pharmacovigilance drug safety autoradiography intranasal administration neurotoxicity
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The main research interest has been to study mechanisms of harmful effects of environmental pollutants, herbicides, carcinogens, and pharmaceuticals in various experimental systems in vivo and in vitro. For instance, she has examined cytochrome P450-catalyzed bioactivation of pharmaceuticals and toxicants and identified some novel potent toxicants in the upper respiratory tract. The studies have been based on both imaging techniques (histopathology, immunohistochemistry, autoradiography) and various in vitro-methods.
Presently she is studying
- neurodegenerative changes in the adult brain following early life exposure to toxicants
- effects of toxicants in cultured neuronal cells
- intranasal administration of therapeutic agents to the brain
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