Helgi Schiöth
Professor at Institutionen för kirurgiska vetenskaper; Funktionell farmakologi och neurovetenskap
- Telephone:
- +46 18 471 41 60
- Mobile phone:
- +46 70 425 05 35
- E-mail:
- helgi.schioth@neuro.uu.se
- Visiting address:
- BMC, Husargatan 3
751 24 Uppsala - Postal address:
- Kirurgiska vetenskaper, Box 593
751 24 Uppsala
- Academic merits:
- PhD, Associate Professor
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Keywords
- professor
Publications
Recent publications
- Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes (2024)
- Synthesis of a Rivastigmine and Insulin Combinational Mucoadhesive Nanoparticle for Intranasal Delivery (2024)
- Exploring sex differences (2024)
- Differential change in alcohol consumption during the COVID-19 pandemic (2024)
- Assessing volumetric brain differences in migraine and depression patients (2023)
All publications
Articles
- Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes (2024)
- Synthesis of a Rivastigmine and Insulin Combinational Mucoadhesive Nanoparticle for Intranasal Delivery (2024)
- Exploring sex differences (2024)
- Differential change in alcohol consumption during the COVID-19 pandemic (2024)
- Assessing volumetric brain differences in migraine and depression patients (2023)
- Volumetric Differences in Cerebellum and Brainstem in Patients with Migraine (2023)
- Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner. (2023)
- Ghrelin's orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation (2023)
- Epigenetic changes in the CYP2D6 gene are related to severity of suicide attempt (2023)
- Job satisfaction has differential associations with delay discounting and risk-taking (2023)
- Higher fresh fruit intake relates to larger grey matter volumes in areas involved in dementia and depression (2023)
- The effects of statins on cognitive performance are mediated by low-density lipoprotein, C-reactive protein and blood glucose concentrations. (2023)
- Identification and validation of volatile organic compounds in bile for differential diagnosis of perihilar cholangiocarcinoma (2023)
- Synthesis of an insulin-loaded mucoadhesive nanoparticle designed for intranasal administration (2023)
- Exploring biomarkers in trigeminal neuralgia patients operated with microvascular decompression (2023)
- Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors (2023)
- Interaction between environmental pollutants and cancer drug efficacy (2023)
- The effect of sunscreen 4-methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand-receptor interaction, and protein expression (2023)
- Knockout of Tmlhe in mice is not associated with autism spectrum disorder phenotypes or motor dysfunction despite low carnitine levels (2023)
- PLBD (2023)
- Perceived stress is related to lower blood pressure in a Swedish cohort (2023)
- Worsened Anxiety and Loneliness Influenced Gaming and Gambling during the COVID-19 Pandemic (2023)
- Well-being spectrum traits are associated with polygenic scores for autism (2023)
- Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis (2023)
- Artificial Neural Network (ANN)-Based Pattern Recognition Approach Illustrates a Biphasic Behavioral Effect of Ethanol in Zebrafish (2023)
- Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation (2023)
- The international clinical trials registry platform (ICTRP) (2023)
- Nanoparticles in Clinical Trials (2023)
- Role of the hypothalamus in ghrelin effects on reproduction (2023)
- Efficacy of combination therapy with GABA, a DPP-4i and a PPI as an adjunct to insulin therapy in patients with type 1 diabetes (2023)
- Effect of worry, depression, and sensitivity to environmental stress owing to neurotic personality on risk of cardiovascular disease (2023)
- Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster (2023)
- Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression (2023)
- Migraine, inflammatory bowel disease and celiac disease (2023)
- Fusobacterium nucleatum- induced exosomal HOTTIP promotes gastric cancer progression through the microRNA-885-3p/EphB2 axis (2023)
- The Epigenetics of Migraine (2023)
- Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy (2022)
- The regulatory role of AP-2 beta in monoaminergic neurotransmitter systems (2022)
- The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila (2022)
- Pharmacogenetics in Primary Headache Disorders (2022)
- Recent developments of phosphodiesterase inhibitors (2022)
- Self-Reported Psychosomatic Complaints and Conduct Problems in Swedish Adolescents (2022)
- Challenges in Analyzing Functional Epigenetic Data in Perspective of Adolescent Psychiatric Health (2022)
- Trends in Antidiabetic Drug Discovery (2022)
- Phonological working memory is adversely affected in adults with anorexia nervosa (2022)
- The influence of personality on the risk of myocardial infarction in UK Biobank cohort (2022)
- Subliminal Emotional Faces Elicit Predominantly Right-Lateralized Amygdala Activation (2022)
- Acylcarnitines (2022)
- Genetics of anorexia nervosa (2022)
- Association of Diligence and Sociability with Stroke (2022)
- GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner (2022)
- Statins and cognition (2022)
- Advances in the development of new biomarkers for Alzheimer's disease (2022)
- Enhanced Toxicity of Bisphenols Together with UV Filters in Water (2022)
- Triple drug therapy with GABA, sitagliptin, and omeprazole prevents type 1 diabetes onset and promotes its reversal in non-obese diabetic mice (2022)
- The potential interaction of environmental pollutants and circadian rhythm regulations that may cause leukemia (2022)
- Can Exposure to Environmental Pollutants Be Associated with Less Effective Chemotherapy in Cancer Patients? (2022)
- Role of the synergistic interactions of environmental pollutants in the development of cancer (2022)
- Misdiagnosis of diabetic foot ulcer in patients with undiagnosed skin malignancies (2022)
- Identification of specific gene methylation patterns during motor neuron differentiation from spinal muscular atrophy patient-derived iPSC (2022)
- Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4) (2022)
- Dissecting the Molecular Mechanisms Surrounding Post-COVID-19 Syndrome and Neurological Features (2022)
- Job satisfaction and job tenure of people with mental health disorders (2022)
- A simple high-throughput method for automated detection of Drosophila melanogaster light-dependent behaviours (2022)
- Dendritic spine density changes and homeostatic synaptic scaling (2022)
- Stem Cells in Clinical Trials on Neurological Disorders (2022)
- Treatment of ADHD (2022)
- Neoantigen Vaccines; Clinical Trials, Classes, Indications, Adjuvants and Combinatorial Treatments (2022)
- Generation of Endogenous Promoter-Driven Luciferase Reporter System Using CRISPR/Cas9 for Investigating Transcriptional Regulation of the Core Clock Gene BMAL1 (2022)
- Ketamine treatment for refractory anxiety (2022)
- How Sleep-Deprived People See and Evaluate Others' Faces (2022)
- The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms (2022)
- HMDB 5.0 (2022)
- Pharmacogenetics and Pain Treatment with a Focus on Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Antidepressants (2022)
- Differential DNA methylation of the genes for amyloid precursor protein, tau and neurofilaments in human traumatic brain injury (2021)
- Major sex differences in migraine prevalence among occupational categories (2021)
- High efficacy of onabotulinumtoxinA treatment in patients with comorbid migraine and depression (2021)
- Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia (2021)
- Neural activation of anxiety and depression in children and young people (2021)
- Trends in kinase drug discovery (2021)
- Characterization of five transmembrane proteins (2021)
- Depression and Vegetarians (2021)
- Ghrelin restores memory impairment following olfactory bulbectomy in mice by activating hippocampal NMDA1 and MAPK1 gene expression (2021)
- Recent developments of HDAC inhibitors (2021)
- BCNNM (2021)
- Important gender differences in psychosomatic and school-related complaints in relation to adolescent weight status (2021)
- HPA axis dysregulation is associated with differential methylation of CpG-sites in related genes (2021)
- A Multilab Replication of the Ego Depletion Effect (2021)
- The Beauty of the Zero (2021)
- The Potential Effect of Insulin on AChE and Its Interactions with Rivastigmine In Vitro (2021)
- Identification of synergistic and antagonistic actions of environmental pollutants (2021)
- Neurological manifestations of COVID-19 (2021)
- Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns (2021)
- Multidrug Resistance Like Protein 1 Activity in Malpighian Tubules Regulates Lipid Homeostasis in Drosophila (2021)
- Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells (2021)
- Integrating Statistical and Machine-Learning Approach for Meta-Analysis of Bisphenol A-Exposure Datasets Reveals Effects on Mouse Gene Expression within Pathways of Apoptosis and Cell Survival (2021)
- Time spent outdoors and risk of myocardial infarction and stroke in middle and old aged adults (2021)
- Sex differences in COVID-19 (2021)
- Rodent and fly models in behavioral neuroscience (2021)
- The Drosophila melanogaster Levodopa-Induced Depression Model Exhibits Negative Geotaxis Deficits and Differential Gene Expression in Males and Females (2021)
- LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling (2021)
- Association between migraine prevalence, treatment with proton-pump inhibitors and CYP2C19 phenotypes in UK Biobank (2021)
- Toll-like receptor 4 methylation grade is linked to depressive symptom severity (2021)
- Therapy response prediction in major depressive disorder (2021)
- Brain Cancer Drug Discovery (2021)
- Assessment of the granulation process effect on morpho-anatomical features and biologically active substances composition of senna leaves (2021)
- Migraine as a risk factor for mixed symptoms of peripartum depression and anxiety in late pregnancy (2021)
- Migraine and gastrointestinal disorders in middle and old age (2021)
- Pharmacological treatment of migraine (2021)
- The Cognitive Effects of Statins are Modified by Age (2020)
- Soluble ligands as drug targets (2020)
- Classification of Trispanins (2020)
- Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches (2020)
- Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions (2020)
- Hypermethylation-associated downregulation of microRNA-4456 in hypersexual disorder with putative influence on oxytocin signalling (2020)
- Review of the Neural Processes of Working Memory Training (2020)
- Normal Testosterone but Higher Luteinizing Hormone Plasma Levels in Men With Hypersexual Disorder (2020)
- Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression (2020)
- meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes (2020)
- Is there prejudice from thin air? (2020)
- Pharmacological NOS-1 Inhibition Within the Hippocampus Prevented Expression of Cocaine Sensitization (2020)
- A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants (2020)
- Important Difference between Occupational Hazard Exposure among Shift Workers and Other Workers; Comparing Workplace before and after 1980 (2020)
- The Synaptic Scaling Literature (2020)
- Excitability, synaptic balance, and addiction (2020)
- Major depression subtypes are differentially associated with migraine subtype, prevalence and severity (2020)
- Personality, lifestyle and job satisfaction (2020)
- Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank (2020)
- Association between sleep duration and executive function differs between diabetic and non-diabetic middle-aged and older adults. (2020)
- Meal timing and subjective sleep disturbances in older men (2020)
- CCAP regulates feeding behavior via the NPF pathway in Drosophila adults (2020)
- Exposure to the environmental pollutant bisphenol A diglycidyl ether (BADGE) causes cell over-proliferation in Drosophila (2020)
- Testosterone, luteinizing hormone levels and methylation status in men with hypersexual disorders (2019)
- The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain. (2019)
- Altered thalamo-cortical and occipital-parietal-temporal-frontal white matter connections in patients with anorexia and bulimia nervosa (2019)
- Memory consolidation impairment induced by Interleukin-1 beta is associated with changes in hippocampal structural plasticity (2019)
- Brain and Cognitive Development in Adolescents with Anorexia Nervosa (2019)
- Low neuroticism and cognitive performance are differently associated to overweight and obesity (2019)
- Preserved white matter microstructure in adolescent patients with atypical anorexia nervosa (2019)
- Functional connectivity underlying hedonic response to food in female adolescents with atypical AN (2019)
- Growth hormone secretagogue receptor signalling affects high-fat intake independently of plasma levels of ghrelin and LEAP2, in a 4-day binge eating model (2019)
- Evidence that genes involved in hedgehog signaling are associated with both bipolar disorder and high BMI (2019)
- A single night of sleep loss impairs objective but not subjective working memory performance in a sex-dependent manner (2019)
- General Principles of Neuronal Co-transmission (2019)
- Plasma levels of leptin and adiponectin and depressive symptoms in young adults (2019)
- Association Between Self-Reported Sleep Duration and Body Composition in Middle-Aged and Older Adults (2019)
- Olesoxime in neurodegenerative diseases (2019)
- Orphan Drugs and Their Impact on Pharmaceutical Development (2018)
- Orphan Drugs and Their Impact on Pharmaceutical Development (2018)
- Reproductive performance of male mice after hypothalamic ghrelin administration (2018)
- Effects of dietary omega-3 PUFAs on growth and development (2018)
- Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans (2018)
- Intranasal insulin in Alzheimer's disease (2018)
- Experimenter gender and replicability in science (2018)
- Changes in methylation within the STK32B promoter are associated with an increased risk for generalized anxiety disorder in adolescents (2018)
- Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359 (2018)
- Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals (2018)
- Altered cerebellar-insular-parietal-cingular subnetwork in adolescents in the earliest stages of anorexia nervosa (2018)
- Epigenetic Changes in the CRH Gene are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents (2018)
- Severity of Suicide Attempt is Associated With Epigenetic and Transcriptional Changes in the CYP2D6 Gene (2018)
- IL-1 beta reduces GluAl phosphorylation and its surface expression during memory reconsolidation and cc-melanocyte-stimulating hormone can modulate these effects (2018)
- Diffusion tensor imaging and tractography of the white matter in normal aging (2018)
- Disruption of Accumbens and Thalamic White Matter Connectivity Revealed by Diffusion Tensor Tractography in Young Men with Genetic Risk for Obesity (2018)
- Atypical anorexia nervosa is not related to brain structural changes in newly diagnosed adolescent patients. (2018)
- Reduced resting-state connectivity in areas involved in processing of face-related social cues in female adolescents with atypical anorexia nervosa (2018)
- Plasma stearoyl-CoA desaturase activity indices and bile acid concentrations after a low-fat meal (2018)
- Neural Cotransmission in Spinal Circuits Governing Locomotion (2018)
- Self-reported sleep disturbances and prostate cancer morbidity and mortality in Swedish men (2018)
- Associations Between the Prevalence of Metabolic Syndrome and Sleep Parameters Vary by Age (2018)
- Melanocortin 4 Receptor Constitutive Activity Inhibits L-Type Voltage-Gated Calcium Channels In Neurons (2017)
- Highly diversified expansions shaped the evolution of membrane bound proteins in metazoans (2017)
- A MIR4646 associated methylation locus is hypomethylated in adolescent depression (2017)
- The Role of Working Memory for Cognitive Control in Anorexia Nervosa versus Substance Use Disorder (2017)
- The impact of cognitive training in substance use disorder (2017)
- Inflammatory markers in late pregnancy in association with postpartum depression-A nested case-control study. (2017)
- Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease (2017)
- Sex matters (2017)
- Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake (2017)
- A genetic risk score is significantly associated with statin therapy response in the elderly population (2017)
- A methylome-wide mQTL analysis reveals associations of methylation sites with GAD1 and HDAC3 SNPs and a general psychiatric risk score (2017)
- Response to Leusink et al. (2017)
- Lower inflammatory markers in women with antenatal depression brings the M1/M2 balance into focus from a new direction (2017)
- Trends in GPCR drug discovery (2017)
- Methylation of Hypothalamic-Pituitary-Adrenal Axis Related Genes in Men with Hypersexual Disorder (2017)
- Methylation of the HPA axis related genes in men with hypersexual disorder (2017)
- Methylation of HPA axis related genes in men with hypersexual disorder (2017)
- Plasma 1-deoxysphingolipids are early predictors of incident type 2 diabetes mellitus (2017)
- NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition (2017)
- Anxiety Disorders are Associated with Low Socioeconomic Status in Women but Not in Men (2017)
- Limbic-thalamo-cortical projections and reward-related circuitry integrity affects eating behavior (2017)
- Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery (2017)
- High leptin levels are associated with migraine with aura (2017)
- A genetic risk score is differentially associated with migraine with and without aura (2017)
- Adolescents Newly Diagnosed with Eating Disorders have Structural Differences in Brain Regions linked with Eating Disorder Symptoms (2017)
- A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels (2017)
- A resting-state fMRI study of obese females between pre- and postprandial states before and after bariatric surgery. (2017)
- A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers (2017)
- Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome (2016)
- A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en Y gastric bypass surgery (2016)
- A genetic risk score is associated with weight loss following Roux-Y gastric bypass surgery (2016)
- Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension (2016)
- Psychological intervention with working memory training increases basal ganglia volume (2016)
- Bis-(2-ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster (2016)
- Bis-(2-ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster (2016)
- mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts (2016)
- Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016)
- A single night of partial sleep loss impairs fasting insulin sensitivity but does not affect cephalic phase insulin release in young men (2016)
- Learning and sleep-dependent consolidation of spatial and procedural memories are unaltered in young men under a fixed short sleep schedule (2016)
- A systematic review of resting-state functional-MRI studies in anorexia nervosa (2016)
- Oxytocin Acting in the Nucleus Accumbens Core Decreases Food Intake (2016)
- Higher resting-state activity in reward-related brain circuits in obese versus normal-weight females independent of food intake (2016)
- Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes (2016)
- microRNA-192 suppresses the expression of the farnesoid X receptor (2016)
- Epigenomics of Total Acute Sleep Deprivation in Relation to Genome-Wide DNA Methylation Profiles and RNA Expression (2016)
- Resting-State Bra in and the FTO Obesity Risk Allele (2016)
- Reduced vasopressin receptors activation mediates the anti-depressant effects of fluoxetine and venlafaxine in bulbectomy model of depression (2016)
- Postprandial alterations in whole-blood DNA methylation are mediated by changes in white blood cell composition (2016)
- Two hours of evening reading on a self-luminous tablet vs. reading a physical book does not alter sleep after daytime bright light exposure (2016)
- A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease (2016)
- One-night sleep deprivation induces changes in the DNA methylation and serum activity indices of stearoyl-CoA desaturase in young healthy men (2016)
- Association between shift work history and performance on the trail making test in middle-aged and elderly humans (2016)
- A new, simple and robust radioligand binding method used to determine kinetic off-rate constants for unlabeled ligands. Application at alpha(2A)- and alpha(2C)-adrenoceptors (2016)
- The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling (2016)
- An obesity-associated risk allele within the FTO gene affects human brain activity for areas important for emotion, impulse control and reward in response to food images (2016)
- Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies (2016)
- Dibutyl Phthalate Exposure Disrupts Evolutionarily Conserved Insulin and Glucagon-Like Signaling in Drosophila Males (2016)
- The Drosophila ETV5 homologue Ets96B (2016)
- BDNF DNA methylation changes as a biomarker of psychiatric disorders (2016)
- The Role of FTO and Vitamin D for the Weight Loss Effect of Roux-en-Y Gastric Bypass Surgery in Obese Patients (2015)
- Self-reported sleep disturbance is associated with Alzheimer's disease risk in men (2015)
- Television Watching and Effects on Food Intake (2015)
- The Orphan G Protein-Coupled Receptor Gene GPR178 Is Evolutionary Conserved and Altered in Response to Acute Changes in Food Intake (2015)
- Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men (2015)
- Short Sleep Makes Declarative Memories Vulnerable to Stress in Humans (2015)
- Determinants of Shortened, Disrupted, and Mistimed Sleep and Associated Metabolic Health Consequences in Healthy Humans (2015)
- Implication of coronin 7 in body weight regulation in humans, mice and flies (2015)
- Gabaergic control of anxiety-like behavior, but not food intake, induced by ghrelin in the intermediate medial mesopallium of the neonatal chick (2015)
- Ghrelin increases memory consolidation through hippocampal mechanisms dependent on glutamate release and NR2B-subunits of the NMDA receptor (2015)
- International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors (2015)
- Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish (2015)
- Patients Lacking Sustainable Long-Term Weight Loss after Gastric Bypass Surgery Show Signs of Decreased Inhibitory Control of Prepotent Responses (2015)
- MicroRNA-192 regulates the expression of the farnesoid X receptor (2015)
- Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families (2015)
- The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system (2015)
- Kiwi genome provides insights into evolution of a nocturnal lifestyle (2015)
- Interleukin-1 beta-induced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and alpha-melanocyte-stimulating hormone prevented these effects (2015)
- Roux-En Y Gastric Bypass Surgery Induces Genome-Wide Promoter-Specific Changes in DNA Methylation in Whole Blood of Obese Patients (2015)
- Ghrelin effects expression of several genes associated with depression-like behavior (2015)
- Scrutinizing the FTO locus (2015)
- Association of the LINGO2-related SNP rs10968576 with body mass in a cohort of elderly Swedes (2015)
- Determination of obesity associated gene variants related to TMEM18 through ultra-deep targeted re-sequencing in a case-control cohort for pediatric obesity. (2015)
- Are you sure? (2015)
- Associations of self-reported sleep disturbance and duration with academic failure in community-dwelling Swedish adolescents (2015)
- Dietary fat quality impacts genome-wide DNA methylation patterns in a cross-sectional study of Greek preadolescents (2015)
- Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers (2015)
- The obesity-linked Nudt3 Drosophila homolog Aps is associated with insulin signalling (2015)
- Methylation Levels of SLC23A2 and NCOR2 Genes Correlate with Spinal Muscular Atrophy Severity (2015)
- Melanocortin 4 receptor activation inhibits presynaptic N-type calcium channels in amygdaloid complex neurons (2014)
- Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity (2014)
- Exposure to a high-fat high-sugar diet causes strong up-regulation of proopiomelanocortin and differentially affects dopamine D1 and D2 receptor gene expression in the brainstem of rats (2014)
- The fat mass and obesity-associated gene (FTO) is linked to higher plasma levels of the hunger hormone ghrelin and lower serum levels of the satiety hormone leptin in older adults (2014)
- Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men (2014)
- BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population (2014)
- Obsessive-compulsivity and working memory are associated with differential prefrontal cortex and insula activation in adolescents with a recent diagnosis of an eating disorder (2014)
- The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas (2014)
- Synaptic changes induced by melanocortin signalling (2014)
- Increased Impulsivity in Response to Food Cues after Sleep Loss in Healthy Young Men (2014)
- Efficacy of antibody-based therapies to treat Alzheimer's disease (2014)
- Watching TV and Food Intake (2014)
- Acute sleep deprivation in healthy young men (2014)
- Replacement of short segments within transmembrane domains of MC2R disrupts retention signal (2014)
- The Drosophila Small GTPase Rac2 is Required for Normal Feeding and Mating Behaviour. (2014)
- Late-life alcohol consumption and cognitive function in elderly men (2014)
- Insights into the Origin of Nematode Chemosensory GPCRs (2014)
- The GPCR repertoire in the demosponge Amphimedon queenslandica (2014)
- New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors (2014)
- Subliminal versus supraliminal stimuli activate neural responses in anterior cingulate cortex, fusiform gyrus and insula (2014)
- The druggable genome (2014)
- CDKAL1-Related Single Nucleotide Polymorphisms Are Associated with Insulin Resistance in a Cross-Sectional Cohort of Greek Children (2014)
- Advances in kinase targeting (2014)
- The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity (2014)
- Long-term oral melatonin administration reduces ethanol-induced increases in duodenal mucosal permeability and motility in rats (2014)
- Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster (2014)
- The Drosophila Kctd-family homologue Kctd12-like modulates male aggression and mating behaviour (2014)
- Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila (2014)
- Exposure to Bisphenol A Affects Lipid Metabolism in Drosophila melanogaster (2014)
- Association between physical activity and brain health in older adults (2013)
- Growth Hormone-Releasing Hormone Improves Cognitive Function in Older Adults (2013)
- Late-life obesity is associated with smaller global and regional gray matter volumes (2013)
- Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity (2013)
- Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet (2013)
- Intranasal Treatment of Central Nervous System Dysfunction in Humans (2013)
- Acute sleep deprivation increases food purchasing in men (2013)
- G Protein-Coupled Receptor Deorphanizations (2013)
- Involvement of the Neutral Amino Acid Transporter SLC6A15 and Leucine in Obesity-Related Phenotypes (2013)
- Molecular mechanisms involved in interleukin 1-beta (IL-1 beta)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (alpha-MSH) (2013)
- Calorie anticipation alters food intake after low-caloric but not high-caloric preloads (2013)
- Sweet taste perception not altered after acute sleep deprivation in healthy young men (2013)
- Acute sleep deprivation increases portion size and affects food choice in young men (2013)
- Effect of oral processing behaviour on food intake and satiety (2013)
- Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system (2013)
- B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brain (2013)
- Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes (2013)
- Remarkable similarities between the hemichordate (Saccoglossus kowalevskii) and vertebrate GPCR repertoire (2013)
- Solute carriers as drug targets (2013)
- The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children (2013)
- Ultra-deep targeted re-sequencing of TMEM18 in two cohorts of European children detects new genetic variants associated with obesity (2013)
- Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects (2013)
- Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children. (2013)
- Mediterranean diet habits in older individuals (2013)
- Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions (2013)
- Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly (2013)
- Early vertebrate origin of melanocortin 2 receptor accessory proteins (MRAPs) (2013)
- Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA (2013)
- Genome-wide analysis shows association of epigenetic changes in regulators of Rab and Rho GTPases with spinal muscular atrophy severity (2013)
- Genome wide analysis reveals association of a FTO gene variant with epigenetic changes (2012)
- Feed-forward mechanisms (2012)
- Dissecting signaling and functions of adhesion G protein-coupled receptors (2012)
- Adhesion GPCRs are widely expressed throughout the subsections of the gastrointestinal tract (2012)
- Impaired Insulin Sensitivity as Indexed by the HOMA Score Is Associated With Deficits in Verbal Fluency and Temporal Lobe Gray Matter Volume in the Elderly (2012)
- Acute Sleep Deprivation Enhances the Brain's Response to Hedonic Food Stimuli (2012)
- Acute sleep deprivation has no lasting effects on the human antibody titer response following a novel influenza A H1N1 virus vaccination (2012)
- Diurnal Rhythm of Circulating Nicotinamide Phosphoribosyltransferase (Nampt/Visfatin/PBEF) (2012)
- Subliminal food images compromise superior working memory performance in women with restricting anorexia nervosa (2012)
- Thinking about Eating Food Activates Visual Cortex with Reduced Bilateral Cerebellar Activation in Females with Anorexia Nervosa (2012)
- Exposure to subliminal arousing stimuli induces robust activation in the amygdala, hippocampus, anterior cingulate, insular cortex and primary visual cortex (2012)
- A debate on current eating disorder diagnoses in light of neurobiological findings (2012)
- Lifestyle determinants of the drive to eat (2012)
- Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population (2012)
- Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system (2012)
- The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO (2012)
- Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children (2012)
- The Origin of GPCRs (2012)
- Expression levels of genes encoding melanin concentrating hormone (MCH) and MCH receptor change in taste aversion, but MCH injections do not alleviate aversive responses (2012)
- Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans (2012)
- Differential effects of fluoxetine and venlafaxine on memory recognition (2012)
- Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice (2012)
- Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats (2012)
- The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children (2012)
- Brain Insulin Signaling and Alzheimer's Disease (2012)
- Insulin to treat Alzheimer's disease (2012)
- Healthcare systems never sleep (2012)
- To Sleep or Not To Sleep (2012)
- The Dispanins (2012)
- The influence of active and passive smoking during pregnancy on umbilical cord blood levels of vitamins A and E and neonatal anthropometric indices (2012)
- Polymorphisms in sh2b1 and spns1 loci are associated with triglyceride levels in a healthy population in northern Sweden (2012)
- Identification of Distant Agouti-Like Sequences and Re-Evaluation of the Evolutionary History of the Agouti-Related Peptide (AgRP) (2012)
- What model organisms and interactomics can reveal about the genetics of human obesity (2012)
- Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men (2011)
- Intranasal insulin as a therapeutic option in the treatment of cognitive impairments (2011)
- Acute sleep deprivation reduces energy expenditure in healthy men (2011)
- The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men (2011)
- Restraint of appetite and reduced regional brain volumes in anorexia nervosa (2011)
- Differential Neural Responses to Food Images in Women with Bulimia versus Anorexia Nervosa (2011)
- Hippocampal effects of neuronostatin on memory, anxiety-like behavior and food intake in rats (2011)
- Comprehensive analysis of localization of 78 solute carrier genes throughout the subsections of the rat gastrointestinal tract (2011)
- Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly (2011)
- Ghrelin inhibited serotonin release from hippocampal slices (2011)
- The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species (2011)
- Detailed Analysis of Variants in FTO in Association with Body Composition in a Cohort of 70-Year-Olds Suggests a Weakened Effect among Elderly (2011)
- Melanocortin receptor subtypes in interrenal cells and corticotropic activity of α-melanocyte-stimulating hormones in barfin flounder, Verasper moseri (2011)
- Independent HHsearch, Needleman-Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families (2011)
- Independent HHsearch, Needleman-Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families (2011)
- Opioids as facilitators of feeding (2011)
- Fto colocalizes with a satiety mediator oxytocin in the brain and upregulates oxytocin gene expression (2011)
- Fto immunoreactivity is widespread in the rodent brain and abundant in feeding-related sites, but the number of Fto-positive cells is not affected by changes in energy balance (2011)
- Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway (2011)
- Trends in the exploitation of novel drug targets (2011)
- Reply to Braasch and Postlethwait (2011)
- GPR162 is expressed in the hypothalamus and is involved in food intake related behaviour (2011)
- Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters (2011)
- The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus (2011)
- Associations between severity of obesity in childhood and adolescence, obesity onset andparental BMI (2011)
- Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae (2011)
- The early origin of melanocortin receptors, agouti-related peptide, agouti signalling peptide, and melanocortin receptor-accessory proteins, with emphasis on pufferfishes, elephant shark, lampreys, and amphioxus (2011)
- Genetic and expression studies of SMN2 gene in Russian patients with spinal muscular atrophy type II and III (2011)
- The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children (2010)
- Dopamine D1 receptor gene expression decreases in the nucleus accumbens upon long-term exposure to palatable food and differs depending on diet-induced obesity phenotype in rats (2010)
- Ghrelin and memory (2010)
- Ghrelin induced memory facilitation implicates nitric oxide synthase activation and decrease in the threshold to promote LTP in hippocampal dentate gyrus (2010)
- Identification of domains responsible for specific membrane transport and ligand specificity of the ACTH receptor (MC2R) (2010)
- SPRIT (2010)
- MDMA (Ecstasy) decreases the number of neurons and stem cells in embryonic cortical cultures (2010)
- Differential expressions of melanocortin receptor subtypes in melanophores and xanthophores of barfin flounder (2010)
- Chronic sugar intake dampens feeding-related activity of neurons synthesizing a satiety mediator, oxytocin (2010)
- Central nociceptin/orphanin FQ system elevates food consumption by both increasing energy intake and reducing aversive responsiveness (2010)
- Molecular, Immunohistochemical, and Pharmacological Evidence of Oxytocin's Role as Inhibitor of Carbohydrate But Not Fat Intake (2010)
- Oxytocin as feeding inhibitor (2010)
- Molecular mechanisms underlying anorexia nervosa (2010)
- Glutamate, aspartate and nucleotide transporters in the SLC17 family form four main phylogenetic clusters (2010)
- Mapping the human membrane proteome (2009)
- Impact of nandrolone decanoate on gene expression in endocrine systems related to the adverse effects of anabolic androgenic steroids (2009)
- Motivation for sucrose in sated rats is predicted by low anxiety-like behavior (2009)
- Anxiolytic response after palatable diet consumption but not food restriction in rats (2009)
- Inverse association of high-fat diet preference and anxiety-like behavior (2009)
- Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks (2009)
- Sequence polymorphism in a marine bivalve (Perna canaliculus) orphan G protein-coupled receptor gene (2009)
- Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors (2009)
- The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents (2009)
- The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924 (2009)
- Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI (2009)
- The Secretin GPCRs descended from the family of Adhesion GPCRs (2009)
- Critical evaluation of the FANTOM3 non-coding RNA transcripts (2009)
- Hypothalamic FTO is associated with the regulation of energy intake not feeding reward (2009)
- Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding (2009)
- Withdrawal from free-choice high-fat high-sugar diet induces craving only in obesity-prone animals (2009)
- Melanocortin peptides affect the motivation to feed in rainbow trout (Oncorhynchus mykiss) (2009)
- Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function (2009)
- The anabolic androgenic steroid nandrolone decanoate affects mRNA expression of dopaminergic but not serotonergic receptors (2008)
- Reduced activity of monoamine oxidase in the rat brain following repeated nandrolone decanoate administration (2008)
- The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain (2008)
- The solute carrier (SLC) complement of the human genome (2008)
- Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat (2008)
- Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents. (2008)
- Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. (2008)
- The relative impact of chronic food restriction and acute food deprivation on plasma hormone levels and hypothalamic neuropeptide expression (2008)
- Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats (2008)
- Food deprivation increases the expression of melanocortin-4 receptor in the liver of barfin flounder, Verasper moseri (2008)
- Structural diversity of G protein-coupled receptors and significance for drug discovery (2008)
- The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors (2008)
- Analysis of the network of feeding neuroregulators using the Allen Brain Atlas (2008)
- Ghrelin in the CNS (2008)
- Allelotyping by massively parallel pyrosequencing of SNP-carrying trinucleotide threads (2008)
- Sensitization to nicotine significantly decreases expression of GABA transporter GAT-1 in the medial prefrontal cortex (2008)
- The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury (2008)
- Anxiety-like behaviour predicts the preference for a high-carbohydrate diet in outbred rats (2007)
- The adhesion GPCRs (2007)
- Identification of novel splice variants of Adhesion G protein-coupled receptors (2007)
- Activation of melanocortin 4 receptors reduces the inflammatory response and prevents apoptosis induced by lipopolysaccharide and interferon-gamma in astrocytes (2007)
- Formation of new genes explains lower intron density in mammalian Rhodopsin G protein-coupled receptors (2007)
- The G protein-coupled receptor subset of the rat genome (2007)
- Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes (2007)
- Further evidence for ancient role of ACTH peptides at melanocortin (MC) receptors; pharmacology of dogfish and lamprey peptides at dogfish MC receptors (2007)
- The evolutionary history and tissue mapping of GPR123 (2007)
- The role of hypothalamic peptide gene expression in alcohol self-administration behavior. (2007)
- Identification of neurotransmitter receptor genes involved in alcohol self-administration in the rat prefrontal cortex, hippocampus and amygdala (2007)
- To press or not to press? Differential receptor expression and response to novelty in rats learning an operant response for reward (2007)
- Mining the gene repertoire and ESTs for G protein-coupled receptors with evolutionary perspective (2007)
- The melanin-concentrating hormone receptor 2 (MCH-R2) mediates the effect of MCH to control body color for background adaptation in the barfin flounder (2007)
- The G protein-coupled receptor subset of the chicken genome (2006)
- Genetic algorithm for large-scale maximum parsimony phylogenetic analysis of proteins (2005)
- Evaluation of EST-data using the genome assembly (2005)
- The human and mouse repertoire of the adhesion family of G-protein-coupled receptors (2004)
- Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes (2004)
- Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair (2004)
- High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3 (2003)
- Dibutyl phthalate exposure disrupts conserved circadian rhythm signaling systems in Drosophila
- Multidrug-Resistance like Protein 1 activity in Malpighian tubules regulates lipid homeostasis in Drosophila
- Developmental bisphenol A diglycidyl ether (BADGE) exposure causes cell over-proliferation in Drosophila
- Pipeline for automated assessment of intra- and inter-individual locomotive behavior in Drosophila melanogaster
- Treatment of two human neuroblastoma cell lines with growth factors, ATRA or VIP alters synaptic vesicle glycoprotein 2 (SV2) expression.
- Antidepressant therapy, subtypes of major depressive disorder and the risk for weight gain
- The statin target Hmgcr regulates energy metabolism and food intake through central mechanisms in Drosophila
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