Jonathan Cedernaes

researcher at Department of Medical Sciences, Transplantation and regenerative medicine

Visiting address:
Akademiska sjukhuset, ingång 40, 5 tr
751 85 Uppsala
Postal address:
Akademiska sjukhuset, Ingång 40, 5 tr
751 85 UPPSALA

Researcher at Department of Medical Cell Biology, Research Group Per-Ola Carlsson

Visiting address:
Husargatan 3
751 23 Uppsala
Postal address:
Box 571
751 23 UPPSALA

Short presentation

The main focus of our research group at the Department of Neuroscience at Uppsala University is to determine the underlying mechanisms and adverse metabolic and neurocognitive effects of disrupted sleep and circadian rhythms in humans.

Peer-reviewed publications

Citations of peer-reviewed publications

Academic merits: PhD

Keywords: sleep deprivation obesity type 2 diabetes circadian disruption core clock genes peripheral metabolism

Articles published in peer-reviewed journals:

  1. Cedernaes J, Huang W, Ramsey KM, Waldeck N, Cheng L, Marcheva B, Omura C, Kobayashi Y, Peek CB, Levine DC, Dhir R, Awatramani R, Bradfield CA, Wang XA, Takahashi JS, Mokadem M, Ahima RS, Bass J. Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron. Cell Metab. 2019 Feb 18. pii: S1550-4131(19)30063-4. [LINK]
  2. Tan X, Cedernaes J, Risérus U, Benedict C. Lack of association between self-reported insomnia symptoms and clamp-derived insulin sensitivity in elderly men. Psychoneuroendocrinology. 2019;102:256-260. doi: 10.1016/j.psyneuen.2018.12.227. [LINK]
  3. Cedernaes J, Schönke M, Westholm JO, Mi J, Chibalin A, Voisin S, Osler M, Vogel H, Hörnaeus K, Dickson SL, Lind SB, Bergquist J, Schiöth HB, Zierath JR, Benedict C. Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans. Sci Adv. 2018;4(8):eaar8590. [LINK]
  4. Rångtell FH, Karamchedu S, Andersson P, Liethof L, Olaya Búcaro M, Lampola L, Schiöth HB, Cedernaes J, Benedict C. A single night of sleep loss impairs objective but not subjective working memory performance in a sex-dependent manner. J Sleep Res. 2019;28(1):e12651. [LINK]
  5. Tan X, Cedernaes J, Forsberg LA, Schiöth HB, Benedict C. Self-reported sleep disturbances and prostate cancer morbidity and mortality in Swedish men: A longitudinal study over 40 years. J Sleep Res. 2018;27(6):e12708. [LINK]
  6. Tan X, Chapman CD, Cedernaes J, Benedict C. Association between long sleep duration and increased risk of obesity and type 2 diabetes: A review of possible mechanisms. Sleep Med Rev. 2017 Nov 20. pii: S1087-0792(17)30091-6. [LINK]
  7. Rai R, Ghosh AK, Eren M, Mackie AR, Levine DC, Kim SY, Cedernaes J, Ramirez V, Procissi D, Smith LH, Woodruff TK, Bass J, Vaughan DE. Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan. Cell Rep. 2017 Nov 7;21(6):1471-1480. [LINK]
  8. Rångtell FH, Karamchedu S, Andersson P, van Egmond L, Hultgren T, Broman JE, Cedernaes J, Benedict C. Learning performance is linked to procedural memory consolidation across both sleep and wakefulness. Sci Rep. 2017 Aug 31;7(1):10234. [LINK]
  9. Tan X, van Egmond L, Chapman CD, Cedernaes J, Benedict C. Aiding sleep in type 2 diabetes: therapeutic considerations. Lancet Diabetes Endocrinol. 2018 Jan;6(1):60-68. [LINK]
  10. Benedict C, Vogel H, Jonas W, Woting A, Blaut M, Schürmann A, Cedernaes J. Gut Microbiota and Glucometabolic Alterations in Response to Recurrent Partial Sleep Deprivation in Normal-weight Young Individuals. Molecular Metabolism, 2016;5(12):1175-1186. [LINK]
  11. Cedernaes J, Fanelli F, Fazzini A, Pagotto U, Broman JE, Vogel H, Dickson SL, Schiöth HB, Benedict C.Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans. Psychoneuroendocrinology. 2016;74:258-268. [LINK]
  12. Peek CB, Levine DC, Cedernaes J, Taguchi A, Kobayashi Y, Tsai SJ, Bonar NA, McNulty MR, Ramsey KM, Bass J. Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle. Cell Metabolism. 2016 Oct 19. pii: S1550-4131(16)30490-9. [LINK]
  13. Cedernaes J, Osorio RS, Varga AW, Kam K, Schiöth HB, Benedict C. Candidate Mechanisms Underlying the Association Between Sleep-Wake Disruptions and Alzheimer’s disease. Sleep Med Rev 2017;31:102-111. [LINK]
  14. Cedernaes J, Bass J. Decoding obesity in the brainstem. eLife. 2016;5. pii: e16393. doi: 10.7554/eLife.16393. [LINK]
  15. Cedernaes J, Sand F, Liethof L, Lampola L, Hassanzadeh S, Axelsson EK, Yeganeh A, Ros O, Broman JE, Schiöth HB, Benedict C. Learning and sleep-dependent consolidation of spatial and procedural memories are unaltered in young men under a fixed short sleep schedule. Neurobiol Learn Mem. 2016;131:87-94. [LINK]
  16. Cedernaes J, Lampola L, Axelsson E, Liethof L, Hassanzadeh S, Yeganeh A, Broman JE, Schiöth HB, Benedict C. A single night of partial sleep loss impairs fasting insulin sensitivity but does not affect cephalic phase insulin release in young men. J Sleep Res. 2016 Feb;25(1):5-10. [LINK]
  17. Cedernaes J, Osler ME, Voisin S, Broman JE, Vogel H, Dickson SL, Zierath JR, Schiöth HB, Benedict C. Acute sleep loss induces tissue-specific epigenetic and transcriptional alterations to circadian clock genes in men. J Clin Endocrinol Metab. 2015;100(9):E1255-61. [LINK]
  18. Cedernaes J, Rångtell FH, Axelsson EK, Yeganeh A, Vogel H, Broman JE, Dickson SL, Schiöth HB, Benedict C. Short sleep makes declarative memories vulnerable to stress in humans. SLEEP. 2015;38(12):1861-8. [LINK]
  19. Cedernaes J, Schiöth HB. Benedict C. Determinants of Shortened, Disrupted, and Mistimed Sleep and Associated Metabolic Health Consequences in Healthy Humans. Diabetes. 2015;64(4):1073-80. [LINK]
  20. Benedict C, Schiöth HB, Cedernaes J. Television watching and effects on food intake: distress vs eustress. JAMA Intern Med. 2015;175(3):468. [LINK]
  21. Benedict C, Byberg L, Cedernaes J, Hogenkamp P, Vilmantas G, Kilander L, Lind L, Lannfelt L, Schiöth HB. Self-reported sleep disturbance is associated with Alzheimer's disease risk in men. Alzheimers Dement. 2015;11(9):1090-7. [LINK]
  22. Cedernaes J, Benedict C. Sleep duration and energy intake: Timing Matters. Am J Clin Nutr. 2014;100(5):1403-4. [LINK]
  23. Chapman CD, Nilsson VC, Thune HÅ, Cedernaes J, Le Grevès M, Hogenkamp PS, Benedict C, Schiöth HB. Watching TV and Food Intake: The Role of Content. PLoS One. 2014;9(7):e100602. doi: 10.1371/journal.pone.0100602. [LINK]
  24. Cedernaes J, Brandell J, Ros O, Broman JE, Hogenkamp PS, Schiöth HB, Benedict C. Increased impulsivity in response to food cues after sleep loss in healthy young men. Obesity (Silver Spring). 2014;22(8):1786-91. [LINK]
  25. Cedernaes J, Benedict C. Human obesity: FTO, IRX3, or both? Mol Metab. 2014;3(5):505-6. [LINK]
  26. Cedernaes J, Schiöth HB, Benedict C. Efficacy of antibody-based therapies to treat Alzheimer's disease: Just a matter of timing? Exp Gerontol. 2014. pii: S0531-5565(14)00141-7. [LINK]
  27. Cedernaes J, Benedict C. Comment on laker et al. Exercise prevents maternal high-fat diet-induced hypermethylation of the pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes 2014 May;63:1605-1611. Diabetes. 2014;63(5):e5. [LINK]
  28. Gremel G, Wanders A, Cedernaes J, Fagerberg L, Hallström B, Edlund K, Sjöstedt E, Uhlén M, Pontén F. The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling. J Gastroenterol. 2015;50(1):46-57. [LINK]
  29. Rosqvist F, Iggman D, Kullberg J, Cedernaes J, Johansson HE, Larsson A, Johansson L, Ahlström H, Arner P, Dahlman I, Risérus U. Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans. Diabetes 2014;63(7):2356-68. [LINK]
  30. Benedict C, Cedernaes J, Giedraitis V, Nilsson E, Hogenkamp P, Vågesjö E, Massena S, Pettersson U, Christoffersson G, Phillipson M, Broman JE, Lannfelt L, Zetterberg H, Schiöth HB. Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men. SLEEP. 2013;37(1):195-198. [LINK]
  31. Chapman CD, Nilsson EK, Nilsson VC, Cedernaes J, Rångtell FH, Vogel H, Dickson SL, Broman JE, Hogenkamp PL, Schiöth HB, Benedict C. Acute sleep deprivation increases food purchasing in men. Obesity. 2013;21(12):E555-60.. [LINK]
  32. Hogenkamp PS, Nilsson E, Chapman CD, Cedernaes J, Vogel H, Dickson SL, Broman JE, Schiöth HB, Benedict C. Sweet taste perception not altered after acute sleep deprivation in healthy young men. Somnologie. 2013;17(2):111-114. [LINK]
  33. Brooks SJ, Cedernaes J, Benedict C, Schiöth HB. Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity: a meta-analysis of fMRI studies. PLoS One. 2013;8(4):e60393. [LINK]
  34. Cedernaes J, Chapman CD, Brünner Y, Schiöth HB, Freiherr J, Benedict C. The influence of intranasal insulin on central nervous system functions in humans. Respiratory drug delivery. 2013;1:59-68.
  35. Hoggenkamp PS, Nilsson E, Nilsson VC, Chapman CD, Vogel H, Lundberg LS, Zarei S, Cedernaes J, Rångtell FH, Broman JE, Dickson SL, Brunstorm JM, Benedict C, Schiöth HB. Acute sleep deprivation increases portion size and affects food choice in young men. Psychoneuroendocrinology. 2013;38(9):1668-74 [LINK].
  36. Cedernaes J, Alsiö J, Risérus U, Schiöth HB. Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. Lipids Health Dis. 2013;12(1):2. [LINK]
  37. Hogenkamp PS, Cedernaes J, Chapman CD, Vogel H, Hjorth O, Zarei S, Lundberg LS, Brooks SJ, Dickson SJ, Benedict C, Schiöth HB. Calorie anticipation alters food intake after low-caloric but not high-caloric preloads. Obesity 2013;21(8):1548-53. [LINK]
  38. Badiali L, Cedernaes J, Olszewski PK, Nylander O, Vergoni AV, Schiöth HB. Adhesion GPCRs are widely expressed throughout the subsections of the gastrointestinal tract. BMC gastroenterol. 2012;12:134. [LINK]
  39. Cedernaes J, Olszewski PK, Almen MS, Stephansson O, Levine AS, Fredriksson R, Nylander O, Schiöth HB. Comprehensive analysis of localization of 78 solute carrier genes throughout the subsections of the rat gastrointestinal tract. Biochem Biophys Res Commun. 2011;411(4):702-7. [LINK]
  40. Almen MS, Jacobsson JA, Shaik JH, Olszewski PK, Cedernaes J, Alsiö J, Sreedharan S, Levine AS, Fredriksson R, Marcus C, Schiöth HB. The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children. BMC Med Genet. 2010;11:58. [LINK]
  41. Olszewski PK, Cedernaes J, Olsson F, Levine AS, Schiöth HB. Analysis of the network of feeding neuroregulators using the Allen Brain Atlas. Neurosci Biobehav Rev. 2008;32(5):945-56. [LINK]

Please contact the directory administrator for the organization (department or similar) to correct possible errors in the information.