Ingrid Glimelius

researcher at Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology; Research group Gunilla Enblad

Email:
ingrid.glimelius[AT-sign]igp.uu.se
Mobile phone:
+46 70 2253912
Visiting address:
Akademiska sjukhuset, ingång 78
751 85 Uppsala
Postal address:
Akademiska sjukhuset, ingång 78
751 85 Uppsala

Short presentation

Senior consultant and associate professor at the Oncology Clinic, Uppsala Akademiska Sjukhus.

Affiliated to the division of Clinical Epidemiology Unit, Karolinska Institutet.

Conducts research about lymphatic malignancies, ovarian cancer and testicular cancer.

I study etiology, prognosis and late-effects (childbearing) in patients that have had lymphoma.

I also focus on pregnancy in relation to a malignant diagnose, with a specific focus on ovarian and testicular cancer.

Keywords: hodgkin lymphoma survivorship ovarian cancer testicular cancer childbirth after cancer

Also available at

My courses

Biography

MD, Uppsala University 2001

PHD, Uppsala University 2009, Hodgkin lymphoma – an interplay between tumour cell and microenvironment

MD, specialist Internal Medicine 2011

MD, specialist Oncology 2013

Associate Professor in Oncology 2016

Good Clinical Practice, Investigator Site Personnel ICH-GCP 2017

Senior Consultant Oncology 2019

Research

Hodgkin lymphoma

Hodgkin lymphoma affects young adults and is today a curable disease with intensive chemotherapy. In this recent article, published in Journal of Clinical Oncology, the childbearing potential in survivors after Hodgkin lymphoma have been investigated together with researcher at Karolinska Institutet Caroline Weibull. We show that in the absence of relapse, contemporarily treated women have an improved childbearing potential with calendar time and women treated today give birth to the same degree as matched comparators.

In a related publication in Journal of Clinical Oncology from 2016 we have earlier shown the safety of having children for female survivors, were there was no increased risk of relapse after a pregnancy

Contemporarily Treated Patients With Hodgkin Lymphoma Have Childbearing Potential in Line With Matched Comparators.

Weibull CE, Johansson ALV, Eloranta S, Smedby KE, Björkholm M, Lambert PC, Dickman PW, Glimelius I. J Clin Oncol. 2018 Jul 25:JCO2018783514. doi: 10.1200/JCO.2018.78.3514. [Epub ahead of print] PMID: 30044694

Pregnancy and the Risk of Relapse in Patients Diagnosed With Hodgkin Lymphoma.

Weibull CE, Eloranta S, Smedby K, Björkholm M, Kristinsson SY, Johansson AL, Dickman PW, Glimelius I. J Clin Oncol. 2016 Feb 1;34(4):337-44. doi: 10.1200/JCO.2015.63.3446. Epub 2015 Dec 14. PMID: 26668344

Mantle Cell Lymphoma

Mantle cell lymphoma is today one of the lymphomas with poor prognosis. I am national principal investigator in the ENRICH-trial (KFUE Akademiska Sjukhuset): A randomized phase III trial in elderly patients with randomization between Rituximab-Ibrutinib AND Rituximab-chemotherapy (Bendamustine or CHOP) with the aim to test if a chemotherapy free concept can improve survival. In addition I am local PI of the VALERIA trial in Uppsala testing Lenalidomide-Venetoclax and Rituximab for relapsed/refractory mantle cell lymphoma patients. In addition I am currently investigating the impact of associated diseases on the prognosis of Mantle Cell Lymphoma. PHD students interested in the field are welcome to contact me.

Recently we investigated comorbidities and causes of death in Mantle Cell Lymphoma patients, showing that the majority of patients dies from the lymphoma, although gender differences exists.

Comorbidities and causes of death in Mantle Cell Lymphoma - a nationwide population-based Glimelius I, Smedby KE, Eloranta S, Jerkeman M, Weibull CE

Br J Haematology, November 13 2019. https://onlinelibrary.wiley.com/doi/10.1111/bjh.16317

Pregnancy and the risk of cancer

In two recent articles published in International Journal of Cancer and a comprehensive review published in Journal of Internal Medicine the associations between pregnancies and later cancer risk in the mother is examined. In the first article we show that a full length pregnancy protects against epithelial ovarian cancer to a higher extent than a pregnancy resulting in preterm delivery. In the next article, we show a decreased risk of breast cancer for females experiencing high blood pressure prior to and during pregnancy. In the review we both illustrate and discuss different aspects of pregnancy and a later risk of several solid malignancies.

Preterm delivery is associated with an increased risk of epithelial ovarian cancer among parous women.

Sköld C, Bjørge T, Ekbom A, Engeland A, Gissler M, Grotmol T, Madanat-Harjuoja L, Gulbech Ording A, Stephansson O, Trabert B, Tretli S, Troisi R, Toft Sørensen H, Glimelius I.

Int J Cancer. 2018 May 8. doi: 10.1002/ijc.31581. [Epub ahead of print] PMID:29737528

Pregnancy Complications and Subsequent Breast Cancer Risk in the Mother: A Nordic population-based case-control study.

Troisi R, Gulbech Ording A, Grotmol T, Glimelius I, Engeland A, Gissler M, Trabert B, Ekbom A, Madanat-Harjuoja L, Toft Sørensen H, Tretli S, Bjørge T.

Int J Cancer. 2018 May 11. doi: 10.1002/ijc.31600. [Epub ahead of print] PMID: 29752724

The role of pregnancy, perinatal factors and hormones in maternal cancer risk: a review of the evidence.

Troisi R, Bjørge T, Gissler M, Grotmol T, Kitahara CM, Myrtveit Saether SM, Ording AG, Sköld C, Sørensen HT, Trabert B, Glimelius I.J Intern Med. 2018 May;283(5):430-445. doi: 10.1111/joim.12747. Epub 2018 Mar 25. PMID:29476569

Publications

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