Celestine Chi

researcher at Department of Medical Biochemistry and Microbiology, Biochemistry and cell- and tumour biology; Chi Celestine

+4618-471 4557
Visiting address:
Husargatan 3
752 37 UPPSALA
Postal address:
Box 582
751 23 UPPSALA

senior research engineer at Department of Chemistry - BMC, Organic Chemistry; Kihlberg group

Visiting address:
Husargatan 3
752 37 Uppsala
Postal address:
Box 576
75123 Uppsala

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Antibiotic resistance is a global pandemic and has gained recognition as an important public issue in the world at large. Its increasing presence hinders and compromises our ability to fight other infectious diseases. There are several mechanisms that lead to the development of antibiotic resistances in gram-negative bacteria. Most antibiotics are targets for intracellular processes. However, they must be able pass through the outer membrane (OM) protective coating of specialized lipid-protein architecture. There is also evidence that drug resistance to antibiotics most often is associated with modification of the lipid-protein composition of the OM. Antibiotics may either penetrate these coatings through a lipid-mediated mechanism or diffuse through porin proteins. The permeability to these drugs is therefore crucial for the fight against these bugs. The mechanistic and molecular basis of how the OM components interact with antibiotics is poorly understood


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