Stefan Enroth
Researcher at Institutionen för immunologi, genetik och patologi; Forskningsprogram: Genomik och Neurobiologi; Forskargrupp Ulf Gyllensten
- E-mail:
- stefan.enroth@igp.uu.se
- Visiting address:
- BMC, Husargatan 3
751 22 Uppsala - Postal address:
- Box 815
751 08 Uppsala
- ORCID:
- 0000-0002-5056-9137
More information is available to staff who log in.
Short presentation
I am an Associate Professor of Computational Genomics in the Dept. of Immunology, Genetics and Pathology. I obtained my PhD in Bioinformatics in 2010 from the Dept. of Cell and Molecular Biology. My research aims at characterizing and understanding factors that influence abundance levels of plasma proteins and use this knowledge to develop personalized models for biomarker discovery in non-communicable diseases and for prediction of personal characteristics from plasma protein profiles
Publications
Selection of publications
- Data-driven analysis of a validated risk score for ovarian cancer identifies clinically distinct patterns during follow-up and treatment (2022)
- Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer. (2022)
- Evaluation of 92 cardiovascular proteins in dried blood spots collected under field-conditions (2021)
- Plasma Proteins and Cancer (2021)
- Identification of Candidate Protein Biomarkers for CIN2+ Lesions from Self-Sampled, Dried Cervico-Vaginal Fluid Using LC-MS/MS (2021)
- Preoperative Fasting and General Anaesthesia Alter the Plasma Proteome (2020)
- Identification of Candidate Plasma Protein Biomarkers for Cervical Cancer Using the Multiplex Proximity Extension Assay (2019)
- High throughput proteomics identifies a high-accuracy 11 plasma protein biomarker signature for ovarian cancer (2019)
- A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer (2018)
- Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases (2018)
- Stability of Proteins in Dried Blood Spot Biobanks. (2017)
- Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease (2017)
- Protein Detection Using the Multiplexed Proximity Extension Assay (PEA) from Plasma and Vaginal Fluid Applied to the Indicating FTA Elute Micro Card™ (2016)
- Effects of Long-Term Storage Time and Original Sampling Month on Biobank Plasma Protein Concentrations (2016)
- Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP) (2015)
- Protein profiling reveals consequences of lifestyle choices on predicted biological aging (2015)
- Nucleosome regulatory dynamics in response to TGF beta (2014)
- Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs (2014)
- Prevalence and sensitization of atopic allergy and coeliac disease in the Northern Sweden Population Health Study (2013)
- Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan (2013)
- Identification of genetic variants influencing the human plasma proteome (2013)
- Genetic Adaptation of Fatty-Acid Metabolism (2012)
- A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements (2012)
- Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing (2012)
- Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa (2011)
- The Nucleosome as a Signal Carrying Unit (2010)
- Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project (2007)
- Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes (2007)
Recent publications
- Toward ovarian cancer screening with protein biomarkers using dried, self-sampled cervico-vaginal fluid (2024)
- The association between genetically elevated polyunsaturated fatty acids and risk of cancer. (2023)
- Forensic prediction of sex, age, height, body mass index, hip-to-waist ratio, smoking status and lipid lowering drugs using epigenetic markers and plasma proteins (2023)
- Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets (2023)
- Data-driven analysis of a validated risk score for ovarian cancer identifies clinically distinct patterns during follow-up and treatment (2022)
All publications
Articles
- Toward ovarian cancer screening with protein biomarkers using dried, self-sampled cervico-vaginal fluid (2024)
- The association between genetically elevated polyunsaturated fatty acids and risk of cancer. (2023)
- Forensic prediction of sex, age, height, body mass index, hip-to-waist ratio, smoking status and lipid lowering drugs using epigenetic markers and plasma proteins (2023)
- Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets (2023)
- Data-driven analysis of a validated risk score for ovarian cancer identifies clinically distinct patterns during follow-up and treatment (2022)
- Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer. (2022)
- Contribution of rare whole-genome sequencing variants to plasma protein levels and the missing heritability (2022)
- Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention (2022)
- Genetic Landscape of the ACE2 Coronavirus Receptor (2022)
- Evaluation of 92 cardiovascular proteins in dried blood spots collected under field-conditions (2021)
- Immune cells lacking Y chromosome show dysregulation of autosomal gene expression (2021)
- Plasma Proteins and Cancer (2021)
- Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19 (2021)
- Distinct genetic regions are associated with differential population susceptibility to chemical exposures (2021)
- Identification of Candidate Protein Biomarkers for CIN2+ Lesions from Self-Sampled, Dried Cervico-Vaginal Fluid Using LC-MS/MS (2021)
- Transcriptome analysis of post-mortem brain tissue reveals up-regulation of the complement cascade in a subgroup of schizophrenia patients (2021)
- Temporal changes in the vaginal microbiota in self-samples and its association with persistent HPV16 infection and CIN2+ (2020)
- Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals (2020)
- Preoperative Fasting and General Anaesthesia Alter the Plasma Proteome (2020)
- Identification of Candidate Plasma Protein Biomarkers for Cervical Cancer Using the Multiplex Proximity Extension Assay (2019)
- HPV viral load in self-collected vaginal fluid samples as predictor for presence of cervical intraepithelial neoplasia. (2019)
- Invasive cervical tumors with high and low HPV titer represent molecular subgroups with different disease etiology (2019)
- High throughput proteomics identifies a high-accuracy 11 plasma protein biomarker signature for ovarian cancer (2019)
- Randomised study of HPV prevalence and detection of CIN2+ in vaginal self-sampling compared to cervical specimens collected by medical personnel. (2019)
- Clinical validation of the HPVIR high-risk HPV test on cervical samples according to the international guidelines for human papillomavirus DNA test requirements for cervical cancer screening (2019)
- Improved power and precision with whole genome sequencing data in genome-wide association studies of inflammatory biomarkers (2019)
- Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations (2019)
- New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (2019)
- Genetic variants influencing phenotypic variance heterogeneity (2018)
- A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer (2018)
- Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases (2018)
- Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. (2018)
- Randomised study shows that repeated self-sampling and HPV test has more than two-fold higher detection rate of women with CIN2+ histology than Pap smear cytology (2018)
- Meta-analysis of exome array data identifies six novel genetic loci for lung function. (2018)
- A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood (2018)
- Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells (2018)
- Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells (2018)
- Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff (2018)
- The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases. (2017)
- Evidence for large-scale gene-by-smoking interaction effects on pulmonary function (2017)
- Stability of Proteins in Dried Blood Spot Biobanks. (2017)
- Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease (2017)
- 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. (2017)
- PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c (2017)
- Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. (2017)
- Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney (2017)
- Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (2017)
- Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target. (2016)
- Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs (2016)
- Protein Detection Using the Multiplexed Proximity Extension Assay (PEA) from Plasma and Vaginal Fluid Applied to the Indicating FTA Elute Micro Card™ (2016)
- Pooled analysis of genome-wide association studies of cervical intraepithelial neoplasia 3 (CIN3) identifies a new susceptibility locus (2016)
- The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals (2016)
- Genome-wide DNA methylation study identifies genes associated with the cardiovascular biomarker GDF-15 (2016)
- Effects of Long-Term Storage Time and Original Sampling Month on Biobank Plasma Protein Concentrations (2016)
- Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function (2016)
- Epigenome-wide association study reveals differential DNA methylation in individuals with a history of myocardial infarction (2016)
- KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference (2016)
- Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP) (2015)
- Protein profiling reveals consequences of lifestyle choices on predicted biological aging (2015)
- Protein profiling reveals consequences of lifestyle choices on predicted biological aging (2015)
- Directional dominance on stature and cognition in diverse human populations (2015)
- Homozygous loss-of-function variants in European cosmopolitan and isolate populations (2015)
- MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures (2015)
- Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation (2015)
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape (2015)
- An Epigenomic Map of Multiple Myeloma Reveals the Importance of Polycomb Gene Silencing for the Malignancy (2014)
- CanvasDB (2014)
- Pathway analysis of cervical cancer genome-wide association study highlights the MHC region and pathways involved in response to infection (2014)
- Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells (2014)
- Nucleosome regulatory dynamics in response to TGF beta (2014)
- Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs (2014)
- Systematic validation of hypothesis-driven candidate genes for cervical cancer in a genome-wide association study (2014)
- Genome-wide association analysis identifies six new loci associated with forced vital capacity (2014)
- Genome-wide Association Study of Susceptibility Loci for Cervical Cancer (2013)
- Omega-3 and omega-6 fatty acids are more efficiently synthesized in populations having a high frequency of the derived FADS-haplotype (2013)
- Prevalence and sensitization of atopic allergy and coeliac disease in the Northern Sweden Population Health Study (2013)
- Assessing The Effects Of Climate Change On Health And Lifestyle In Sub-Arctic Areas In Sweden - The Northern Sweden Population Health Study (2013)
- Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan (2013)
- Identification of genetic variants influencing the human plasma proteome (2013)
- Peak Finder Metaserver - a novel application for finding peaks in ChIP-seq data (2013)
- Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels (2013)
- Genetic Adaptation of Fatty-Acid Metabolism (2012)
- A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements (2012)
- Combinations of histone modifications mark exon inclusion levels (2012)
- Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing (2012)
- Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa (2011)
- SICTIN (2010)
- Integrative epigenomic and genomic analysis of malignant pheochromocytoma (2010)
- Nucleosomes are well positioned in exons and carry characteristic histone modifications (2009)
- Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection (2009)
- Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation (2009)
- Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing (2009)
- Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing (2009)
- Monte Carlo feature selection for supervised classification (2008)
- Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation (2008)
- Whole-genome maps of USF1 and USF2 binding and histone H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorders (2008)
- Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project (2007)
- Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes (2007)
- Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays (2005)
- The epigenomic map of multiple myeloma reveals the importance of Polycomb gene silencing for the malignancy
- Peak Finder Metaserver - a novel application for finding peaks in ChIP-seq data
Books
Conferences
