Oommen Varghese
Senior Lecturer/Associate Professor at Department of Chemistry - Ångström Laboratory; Macromolecular Chemistry
- Telephone:
- +46 18 471 38 32
- Mobile phone:
- +46 72 503 63 98
- Fax:
- +46 18 471 34 77
- E-mail:
- oommen.varghese@kemi.uu.se
- Visiting address:
- Lägerhyddsvägen 1
- Postal address:
- Box 538
751 21 Uppsala
More information is available to staff who log in.
Short presentation
Our ambition is to lead a frontier research that combines synthetic organic chemistry, cell and molecular biology and preclinical research for translational medicine. We have an international team of scientists with complementary skills and we are always looking for ambitious researchers (students and postdocs) with the passion for Science. To know more about our research, please visit our Homepage.
Keywords
- anticancer therapy
- biomaterials
- drug delivery
- gene knockdown
- nucleic acid chemistry
- tissue engineering
Biography
Oommen Varghese is an Associate Professor and University Lecturer at the Department of Chemistry, Ångström laboratory in the Polymer Chemistry program. Since 2011, he is a group leader at the Translational Chemical Biology laboratory and leads an independent research in biomaterial science, regenerative medicine (bone tissue engineering) and nucleic acids therapeutics. He has a state-of-the-art research facility that combines facilities to perform organic synthesis as well as cell and molecular biology. His interdisciplinary research team comprises of Ph.D. students, postdocs and masters students with exceptional skills in cell biology and synthetic chemistry. Currently, he is developing chemically modified nucleic acids (engineered plasmid DNA, short interfering RNA, and microRNA) that has the potential for clinical translation as it addresses some of the major bottlenecks in the field. Biomaterial research combined with nucleic acids therapeutics and regenerative medicine is the highlight of his research.
Research
I have a multi-disciplinary research interest from basic science to translational research. This include (1) basic organic chemistry (2) nucleic acid chemistry (3) biomaterial research (4) synthetic biology (5) stem cell research (6) regenerative medicine (7) anticancer therapy
Please visit my homepage for more details (link below).
https://kemi.uu.se/angstrom/research/macromolecular-chemistry/research-groups/varghese-group
Publications
Recent publications
- Physically and Chemically Crosslinked Hyaluronic Acid-Based Hydrogels Differentially Promote Axonal Outgrowth from Neural Tissue Cultures (2024)
- Advances in Intracellular and On-Surface Polymerization in Living Cells (2023)
- Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function (2023)
- Unveiling extracellular matrix assembly (2023)
- Educational challenges for teaching nanotechnology (2023)
All publications
Articles
- Physically and Chemically Crosslinked Hyaluronic Acid-Based Hydrogels Differentially Promote Axonal Outgrowth from Neural Tissue Cultures (2024)
- Advances in Intracellular and On-Surface Polymerization in Living Cells (2023)
- Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function (2023)
- Unveiling extracellular matrix assembly (2023)
- Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model (2022)
- Interpenetrating gallol functionalized tissue adhesive hyaluronic acid hydrogel polarizes macrophages to an immunosuppressive phenotype (2022)
- Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications (2022)
- Effect of the Addition Frequency of 5-Azacytidine in Both Micro- and Macroscale Cultures (2021)
- Redox responsive Pluronic micelle mediated delivery of functional siRNA (2021)
- Discrepancies on the Role of Oxygen Gradient and Culture Condition on Mesenchymal Stem Cell Fate (2021)
- An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels (2021)
- PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications (2020)
- Modulating thiol pKa promotes disulfide formation at physiological pH (2019)
- First Aldol Cross-Linked Hyaluronic Acid Hydrogel (2019)
- MicroRNA detection based on duplex-specific nuclease-assisted target recycling and gold nanoparticle/graphene oxide nanocomposite-mediated electrocatalytic amplification (2019)
- Synthetic design of asymmetric miRNA with engineered 3′-overhang to improve strand selection (2019)
- A turn-on fluorescent GFP chromophore analog for highly selective and efficient detection of H2S in aqueous and in living cells (2019)
- 4 '-Guanidinium-modified siRNA (2019)
- Innovative strategy for 3D transfection of primary human stem cells with BMP-2 expressing plasmid DNA (2019)
- Insights into siRNA Transfection in Suspension (2019)
- An Unexpected Role of Hyaluronic Acid in Trafficking siRNA Across the Cellular Barrier (2019)
- Impact of Hydrogel Cross-Linking Chemistry on the in Vitro and in VivoBioactivity of Recombinant Human Bone Morphogenetic Protein-2 (2019)
- Influence of ions to modulate hydrazone and oxime reaction kinetics to obtain dynamically cross-linked hyaluronic acid hydrogels (2019)
- Thiazolidine chemistry revisited (2018)
- Bi-directional cell-pericellular matrix interactions direct stem cell fate (2018)
- Saline Accelerates Oxime Reaction with Aldehyde and Keto Substrates at Physiological pH (2018)
- Synthetic design of growth factor sequestering extracellular matrix mimetic hydrogel for promoting in vivo bone formation (2018)
- Injectable and thermoresponsive pericardial matrix derived conductive scaffold for cardiac tissue engineering (2017)
- Host cell recruitment patterns by bone morphogenetic protein-2 releasing hyaluronic acid hydrogels in a mouse subcutaneous environment (2017)
- Chondroitin sulfate coated gold nanoparticles (2016)
- Multifunctional Hyaluronic Acid and Chondroitin Sulfate Nanoparticles (2016)
- Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery (2016)
- 2 '-N-Guanidino, 4 '-C-ethylene bridged thymidine (GENA-T) modified oligonucleotide exhibits triplex formation with excellent enzymatic stability (2015)
- Insights into the Mechanism and Catalysis of Oxime Coupling Chemistry at Physiological pH (2015)
- Chondroitin Sulfate-Coated DNA-Nanoplexes Enhance Transfection Efficiency by Controlling Plasmid Release from Endosomes (2015)
- Host cell recruitment patterns by BMP-2 releasing hyaluronic acid gels in a mouse subcutaneous model (2014)
- Tailored Doxorubicin-Hyaluronan Conjugate as a Potent Anticancer Glyco-Drug (2014)
- Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells (2014)
- Smart Design of Stable Extracellular Matrix Mimetic Hydrogel (2013)
- PLGA/PEG-hydrogel composite scaffolds with controllable mechanical properties (2013)
- Mild and Efficient Strategy for Site-Selective Aldehyde Modification of Glycosaminoglycans (2013)
- Keynote: Safe and efficient in-vivo gene gene transfer and silencing technologies using natural pathways (2012)
- Critical Assessment of rhBMP-2 Mediated Bone Induction (2012)
- Critical assessment of rhBMP-2 mediated bone induction (2012)
- Minimally invasive mandibular bone augmentation using injectable hydrogels (2012)
- Smart design of stable hydrazone crosslinked extracellular matrix mimetic hydrogel for tissue engineering application (2012)
- Injectable hyaluronic acid hydrogel for bone tissue engineering (2012)
- Bone reservoir (2011)
- Functionalization of Hyaluronic Acid with Chemoselective Groups via a Disulfide-Based Protection Strategy for In Situ Formation of Mechanically Stable Hydrogels (2010)
- Modular approach to functional hyaluronic acid hydrogels using orthogonal chemical reactions (2010)
- Synthesis of Guanidinium-Modified Hyaluronic Acid Hydrogel (2010)
- In Situ Cross-Linkable High Molecular Weight Hyaluronan−Bisphosphonate Conjugate for Localized Delivery and Cell-Specific Targeting (2009)
- Comparison of the RNase H Cleavage Kinetics and Blood Serum Stability of the North-Conformationally Constrained and 2‘-Alkoxy Modified Oligonucleotides (2007)
- The chemical nature of the 2'-substituent in the pentose-sugar dictates the pseudoaromatic character of the nucleobase (pKa) in DNA/RNA. (2006)
- The chemical nature of the 2'-substituent in the pentosesugar dictates the pseudoaromatic character of the nucleobase (pKa) in DNA/RNA (2006)
- Synthesis and Structure of Novel Conformationally-constrained 1'2'-Azetidine-Fused Bicyclic Pyrimidine Nucleosides: Their Incorporation into Oligo-DNAs and the Thermal Stability of the Heteroduplexes (2006)
- Conformationally Constrained 2'-N,4'-C-Ethylene-Bridged Thymidine (Aza-ENA-T): Synthesis, Structure, Physical, and Biochemical Studies of Aza-ENA-T-Modified Oligonucleotides (2006)
- First Aldol-Crosslinked Hyaluronic Acid Hydrogel: Fast and Hydrolytically Stable Gel with Tissue Adhesive Properties
- New insight on siRNA transfection in three dimensions: Improved gene silencing in human mesenchymal stem cells encapsulated in hyaluronicacid hydrogel
- Hyaluronic acid facilitates non-cationic siRNA delivery and gene silencing in CD44 positive cells
- Rational Design of Biomaterials for Growth Factor Delivery: Impact of Hydrogel Crosslinking Chemistry on the In Vitroand In VivoBioactivity of Recombinant Human Bone Morphogenetic Protein-2
- Saline catalyse oxime reaction at physiological pH
Reports
