Nils Landegren

physician at Department of Medical Sciences

Email:
nils.landegren[AT-sign]medsci.uu.se
Telephone:
+4618-6112957
Visiting address:
Akademiska sjukhuset, ingång 40, 5 tr
751 85 UPPSALA
Postal address:
Akademiska sjukhuset, Ing. 40, 5 t
SE-751 85 UPPSALA
Sweden

Short presentation

The aim of my research is to understand mechanisms involved in autoimmune disease development.

We use proteomic technologies to characterise autoimmune disorders and to identify diagnostic markers.

In an ongoing collaboration, I hope to understand why women face an increased risk of developing autoimmune disorders. By following men and women who undergo sex change we can investigate how sex hormones affect the human immune system.

Also available at

My courses

Biography

Licenced physician 2018

PhD 2015, Uppsala University

MD 2011, Uppsala University

Academic honours, awards and prizes

Swedish Society for Medical Research Postdoctoral Fellowship, 2018

The Swedish Association of Endocrinologists’ Research Stipend of the Year, 2017

The Crafoord Stipend, 2016

Benzeliusbelöning, from the Royal Society of Sciences in Uppsala, 2015

Best Thesis award from the Department of Medical Sciences, Uppsala University, 2015

Thesis of the Year from The Swedish Association of Endocrinologists, 2015

SciLifeLab Scientific Highlight, recognizing Landegren et al. Science Translational Medicine 2015

Swedish Society for Medical Research Travel grant for exchange to Stanford University, 2012

Research

The aim of my research is to understand mechanisms involved in autoimmune disease and to improve diagnostic opportunities for these disorders.

Autoantibodies as markers of disease. We use proteome arrays to characterize autoantibody responses and to identify biomarkers. We also develop targeted panels to support clinical diagnostics of autoimmune disorders. We are currently developing a tool to screen many thousands of samples for autoantibodies in parallel.

Defects in immune tolerance. We study rare monogenic disorders as models to understand the role of central tolerance (APS1) and peripheral tolerance (IPEX) in the development of autoimmunity.

Transglutaminases as autoimmune targets. One of the autoantigens we have identified, transglutaminase 4, is a prostate-specific member of the transglutaminase protein family. Previous studies have identified other members of this protein family as autoantigens in distinct autoimmune disorders. Inspired by this, we now pursue remaining transglutaminases as candidate autoantigens.

Sex differences in autoimmunity. Women face a three-fold higher risk of developing an autoimmune disorder. In an ongoing collaboration we follow men and women undergoing sex change, as a unique model to study how sex hormones affect the human immune system. Samples are collected before and during hormone therapy, and analyzed using a combination of omics technologies.

Financial support

The Swedish Society of Medicine

Swedish Society for Medical Research

Crafoord foundation

Åke Wiberg foundation

The Swedish Association of Endocrinologists

Marcus Borgström foundation

Selander foundation

Magnus Bergvall foundation

Tore Nilson foundation

Department of Medical Sciences, Uppsala University

Novo Nordisk foundation (coapplicant)

Publications

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