Olof Eriksson

Kort presentation

Nyckelord

• beta cell imaging
• biomedical image analysis
• diabetes
• immunotherapy
• inflammation
• molecular imaging
• neuroendocrine cancer
• pharmaceuticals
• positron emission tomography
• translational research

Publikationer

Senaste publikationer

• Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor (2024)
• In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients (2023)
• [¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44 (2023)
• Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells. (2023)
• Radiotracers for Imaging of Fibrosis (2023)

Alla publikationer

Artiklar

• Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor (2024)
• In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients (2023)
• [¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44 (2023)
• Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells. (2023)
• Radiotracers for Imaging of Fibrosis (2023)
• Monitoring beta-Cell Survival After Intrahepatic Islet Transplantation Using Dynamic Exendin PET Imaging (2023)
• PET imaging of neutrophil elastase with ¹¹C-GW457427 in Acute Respiratory Distress Syndrome in pigs (2023)
• Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences (2023)
• Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β (2023)
• Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist (2022)
• Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes (2022)
• PET-CT imaging of pulmonary inflammation using [Ga-68]Ga-DOTA-TATE (2022)
• Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model (2022)
• The Current State of Beta-Cell-Mass PET Imaging for Diabetes Research and Therapies (2021)
• PET Imaging of GPR44 by Antagonist [C-11]MK-7246 in Pigs (2021)
• News ways of understanding the complex biology of diabetes using PET (2021)
• Drug Occupancy Assessment at the Glucose-Dependent Insulinotropic Polypeptide Receptor by Positron Emission Tomography (2021)
• Imaging of the Glucagon Receptor in Subjects with Type 2 Diabetes (2021)
• Longitudinal Assessment of ¹¹C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes (2021)
• Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography (2021)
• Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69 (2021)
• Potential of [C-11]UCB-J as a PET tracer for islets of Langerhans (2021)
• Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1 (2021)
• Improved Radiolytic Stability of a ⁶⁸Ga-labelled Collagelin Analogue for the Imaging of Fibrosis (2021)
• Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease (2021)
• Receptor occupancy of dual glucagon-like peptide 1/glucagon receptor agonist SAR425899 in individuals with type 2 diabetes (2020)
• [¹¹C]5-Hydroxy-tryptophan model for quantitative assessment of in vivo serotonin biosynthesis, retention and degradation in the endocrine pancreas (2020)
• Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics (2020)
• Heterogeneity of Metabolic Defects in Type 2 Diabetes and Its Relation to Reactive Oxygen Species and Alterations in Beta-Cell Mass (2019)
• Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass (2019)
• GPR44 as a Target for Imaging Pancreatic Beta-Cell Mass (2019)
• Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes. (2019)
• Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates (2019)
• Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI (2019)
• Tools for Bioimaging Pancreatic beta Cells in Diabetes (2019)
• Overeating saturated fat promotes fatty liver and ceramides compared to polyunsaturated fat (2019)
• First-in-class positron emission tomography tracer for the glucagon receptor (2019)
• Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus (2018)
• In Vivo Visualization of beta-Cells by Targeting of GPR44 (2018)
• Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8 (2018)
• Detection and quantification of beta cells by PET imaging (2018)
• The development of a GPR44 targeting radioligand [¹¹C]AZ12204657 for in vivo assessment of beta cell mass. (2018)
• Cannabinoid Type 1 Receptors Are Upregulated During Acute Activation of Brown Adipose Tissue (2018)
• Increased Expression of GLP-1R in Proliferating Islets of Men1 Mice is Detectable by [Ga-68]Ga-DO3A-VS-Cys(40)- Exendin-4/PET (2018)
• [(11)C]5-Hydroxy-Tryptophan PET for Assessment of Islet Mass During Progression of Type 2 Diabetes (2017)
• Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4 (2017)
• Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations (2017)
• Toward molecular imaging of the free fatty acid receptor 1 (2017)
• Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes (2017)
• Radiochemistry and Preclinical Evaluation of Two Novel Peptide Analogues Targeting Glucagon Receptor for AntiDiabetic Drug Development (2017)
• Fully automated GMP production of [Ga-68]Ga-DO3A-VS-Cys(40)-Exendin-4 for clinical use (2017)
• Pancreatic perfusion and subsequent response to glucose in healthy individuals and patients with type 1 diabetes (2016)
• In vivo imaging of beta cells with radiotracers (2016)
• Positron Emission Tomography to assess the outcome of intraportal islet transplantation (2016)
• Quantification of Beta-Cell Mass in Intramuscular Islet Grafts using Radiolabeled Exendin-4 (2016)
• Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma (2016)
• GPR44 is a pancreatic protein restricted to the human beta cell (2016)
• Cannabinoid CB1 receptors in human brown adipose tissue during cold exposure (2016)
• Cardiovascular side-effects and insulin secretion after intravenous administration of radiolabeled Exendin-4 in pigs (2016)
• Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model. (2016)
• Feasibility of Multiple Examinations Using Ga-68-Labelled Collagelin Analogues (2016)
• Ga-68/PET imaging and quantification of fibrosis using peptide-based tracers (2016)
• [C-11] Carfentanil Binds Preferentially to mu-Opioid Receptor Subtype 1 Compared to Subtype 2 (2015)
• Synthesis and biological evaluation of [C-11]AZ12504948; a novel tracer for imaging of glucokinase in pancreas and liver (2015)
• Systematic screening of imaging biomarkers for the Islets of Langerhans, among clinically available positron emission tomography tracers (2015)
• Molecular imaging of EGFR and EGFRvIII for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model (2015)
• Rat organ distribution of [Lu-177]-DO3A-VS-Cys(40)-Exendin-4 for the estimation of human dosimetry (2015)
• Extrapolated dosimetry of two novel Ga-68-labelled imaging agents for fibrosis (2015)
• Dosimetry of [Ga-68]Ga-DO3A-VS-Cys(40)-Exendin-4 in rodents, pigs, non-human primates and human (2015)
• Dosimetry of 68Ga and 177Lu labeled Exendin4-impact on feasibility of repeated PET imaging and radiotherapy (2014)
• 5-Hydroxy-L-[beta-C-11]-tryptophan Deuterium Isotopologue Shows Increased Retention In Neuro-endocrine Cells Due To Secondary Kinetic Isotope Effect (2014)
• Strategy to develop a MAO-A-resistant 5-hydroxy-L-[beta-C-11]tryptophan isotopologue based on deuterium kinetic isotope effects (2014)
• The Positron Emission Tomography ligand [11C]5-Hydroxy-Tryptophan can be used as a surrogate marker for the human endocrine pancreas (2014)
• On the use of [F-18]DOPA as an imaging biomarker for transplanted islet mass (2014)
• Quantitative Imaging of Serotonergic Biosynthesis and Degradation in the Endocrine Pancreas (2014)
• Detection of Metastatic Insulinoma by Positron Emission Tomography with [(68)Ga]Exendin-4 - (2014)
• Positron emission tomography imaging of the glucagon-like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
• Positron Emission Tomography imaging of the glucagon like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
• PET imaging of the GLP-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
• Pre-clinical evaluation of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma (2014)
• Dosimetry of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 in rat, non-human primate and human (2014)
• Gallium-68-labeled affibody molecule for PET imaging of PDGFR beta expression in vivo (2014)
• Gallium-68-Labeled Affibody Molecule for PET Imaging of PDGFRβ Expression in Vivo (2014)
• Development of a I-124-labeled version of the anti-PSMA monoclonal antibody capromab for immunoPET staging of prostate cancer (2014)
• Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591 (2014)
• Synthesis and preclinical evaluation of Ga-68-labeled collagelin analogs for imaging and quantification of fibrosis (2014)
• 5-Fluoro-[beta-C-11]-L-tryptophan is a functional analogue of 5-hydroxy-[beta-C-11]-L-tryptophan in vitro but not in vivo (2013)
• Imaging the in vivo fate of human T cells following transplantation in immunoincompetent mice - Implications for clinical cell therapy trials (2013)
• beta-Cell Mass Imaging with DTBZ Positron Emission Tomography (2013)
• 5-Fluoro-[beta-C-11]-L-tryptophan is a functional analogue of 5-hydroxy-[beta-C-11]-L-tryptophan in vitro but not in vivo (2013)
• Functional Imaging of the Pancreatic Graft by Positron Emission Tomography (2013)
• In Vivo Imaging of the Glucagonlike Peptide 1 Receptor in the Pancreas with Ga-68-Labeled DO3A-Exendin-4 (2013)
• In vivo imaging of PDGFR beta expression using In-111-DOTA-Z09591 Affibody molecule (2013)
• Imaging of PDGFRbeta expression in vivo using Affibody molecule In-111-DOTA-Z09591 (2013)
• Synthesis and preclinical evaluation of Ga-68-labelled collagelin analogues for imaging and quantification of fibrosis (2013)
• Ga-68-labelling of Exendin-4, preclinical evaluation of the resultant tracer for the imaging and quantification of insulinomas, and case patient examination (2013)
• Imaging the islet graft by positron emission tomography (2012)
• Preclinical evaluation of a ⁶⁸Ga-labeled biotin analogue for applications in islet transplantation (2012)
• Pancreatic uptake of [68Ga]DO3A-Exendin4 is mediated by the GLP-1 receptor (2012)
• Assessment of receptor occupancy-over-time of two dopamine transporter inhibitors by [C-11]CIT and target controlled infusion (2011)
• Distribution of adoptively transferred porcine T-lymphoblasts tracked by (18)F-2-fluoro-2-deoxy-D-glucose and position emission tomography (2011)
• Striated Muscle as Implantation Site for Transplanted Pancreatic Islets (2011)
• Decreased defluorination using the novel beta-cell imaging agent [¹⁸F]FE-DTBZ-d4 in pigs examined by PET (2011)
• In vivo and in vitro characterization of [¹⁸F]-FE-(+)-DTBZ as a tracer for beta-cell mass (2010)
• Positron emission tomography in clinical islet transplantation (2009)
• Synthesis and in vitro evaluation of ¹⁸F-β-carboline alkaloids as PET ligands (2008)
• Positron emission tomography and target-controlled infusion for precise modulation of brain drug concentration (2008)
• A computerized Infusion Pump for control of tissue tracer concentration during Positron Emission Tomography in vivo Pharmacokinetic/Pharmacodynamic measurements (2008)
• Visualization of early engraftment in clinical islet transplantation by positron-emission tomography (2007)
• Positron emission tomography (2007)
• Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET (2006)
• Lead compound identification from first-in-class high affinity Affibody molecules binders towards DGCR2
• Preclinical evaluation of Affibody molecule ¹⁸F-TZ-Z_AM106 for PET imaging of DGCR2
• Non-invasive imaging methodologies for assessment of Peptide Receptor Radiotherapy damage to bone marrow and kidney
• Positron Emission Tomography imaging of CD69 in a murine model of rheumatoid arthritis

Böcker

• Imaging Islets of Langerhans by Positron Emission Tomography (2011)

Konferenser

• Synthesis and initial preclinical evaluation of the CRTH2 antagonist [C-11] MK-7246 (2019)