Aristidis Moustakas

Publikationer

Senaste publikationer

• The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion (2023)
• Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation (2023)
• The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition (2023)
• The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma (2022)
• Dual inhibition of TGF-beta and PD-L1 (2022)

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Artiklar

• The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion (2023)
• Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation (2023)
• The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition (2023)
• The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma (2022)
• Dual inhibition of TGF-beta and PD-L1 (2022)
• Mast cell chymase has a negative impact on human osteoblasts (2022)
• Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity (2022)
• Cellular heterogeneity in pancreatic cancer (2022)
• Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells (2022)
• TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition (2022)
• Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types (2021)
• The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma (2021)
• BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells (2021)
• The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling (2021)
• NUAK1 and NUAK2 Fine-Tune TGF-β Signaling (2021)
• BMP signaling is a therapeutic target in ovarian cancer (2020)
• Long non-coding RNAs and TGF-beta signaling in cancer (2020)
• Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies (2020)
• TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness (2020)
• TGF-β Signaling (2020)
• Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells (2019)
• Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer (2019)
• Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output (2019)
• LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation (2019)
• The TGFB2-AS1 lncRNA Regulates TGF-beta Signaling by Modulating Corepressor Activity (2019)
• The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity (2019)
• JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses (2019)
• TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells (2019)
• Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma (2018)
• Serglycin promotes breast cancer cell aggressiveness (2018)
• TGF-β and the Tissue Microenvironment (2018)
• Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells (2018)
• Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases (2018)
• TGF-beta Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition (2018)
• TGF-beta Family Signaling in Ductal Differentiation and Branching Morphogenesis (2018)
• Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells (2018)
• Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells (2018)
• Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor (2018)
• The protein kinase SIK downregulates the polarity protein Par3 (2018)
• Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells (2017)
• Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells (2017)
• Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1 (2017)
• Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer (2017)
• Epithelial-mesenchymal transition in cancer (2017)
• Transforming growth factor beta as regulator of cancer stemness and metastasis (2016)
• TGF beta and the nuclear receptor LXR alpha crosstalk on lipid metabolism and epithelial to mesenchymal transition in hepatocellular carcinoma (2016)
• Single Chain Antibodies as Tools to Study transforming growth factor--Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens (2016)
• Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF- Signaling (2016)
• Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation (2016)
• Mechanisms of action of bone morphogenetic proteins in cancer (2016)
• The rationale for targeting TGF-beta in chronic liver diseases (2016)
• Signaling Receptors for TGF-beta Family Members (2016)
• Mechanisms of TGF beta-Induced Epithelial-Mesenchymal Transition (2016)
• In vitro and ex vivo vanadium antitumor activity in (TGF-beta)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients (2016)
• The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling (2016)
• Ras and TGF-beta signaling enhance cancer progression by promoting the Delta Np63 transcriptional program (2016)
• Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation (2016)
• Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells (2015)
• Transforming growth factor beta and bone morphogenetic protein actions in brain tumors (2015)
• Tamoxifen Inhibits TGF-beta-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2 (2015)
• MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures (2015)
• Transforming growth factor beta and bone morphogenetic protein actions in cancer progression (2015)
• The mitotic checkpoint protein kinase BUB1 is an engine in the TGF-beta signaling apparatus (2015)
• Targeting Tgf-Beta I With The Transforming Growth Factor Receptor Type I Kinase Inhibitor, Ly2157299, Modulates Stemness-Related Biomarkers In Hepatocellular Carcinoma (2015)
• The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition (2015)
• Reprogramming during epithelial to mesenchymal transition under the control of TGF beta (2015)
• Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling (2014)
• Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells (2014)
• Nucleosome regulatory dynamics in response to TGF beta (2014)
• Invasive cells follow Snail's slow and persistent pace (2014)
• TGF beta and matrix-regulated epithelial to mesenchymal transition (2014)
• Knock-Down of CD44 Regulates Endothelial Cell Differentiation via NF kappa B-Mediated Chemokine Production (2014)
• HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment (2013)
• The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins (2013)
• Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells (2013)
• Coordination of TGF-beta Signaling by Ubiquitylation (2013)
• p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β (2013)
• Context-dependent action of transforming growth factor β family members on normal and cancer stem cells (2012)
• Role of Smads in TGFβ signaling (2012)
• Regulation of EMT by TGFβ in cancer (2012)
• Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase (2012)
• Induction of epithelial-mesenchymal transition by transforming growth factor β (2012)
• Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24 (2012)
• Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition (2012)
• Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase (2012)
• Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1) (2011)
• Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype (2011)
• Regulation of Myosin Light Chain Function by BMP Signaling Controls Actin Cytoskeleton Remodeling (2011)
• Hyaluronan-CD44 interactions as potential targets for cancer therapy (2011)
• Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1 (2011)
• TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2 (2011)
• Role of TGF-β signaling in EMT, cancer progression and metastasis (2011)
• Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins (2011)
• The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma. (2011)
• TGF beta Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death (2011)
• SIK phosphorylates and degrades Par3 to mediate tight junction disassembly during epithelial-mesenchymal transition (2011)
• Hyaluronan Synthesis Is Inhibited by Adenosine Monophosphate-activated Protein Kinase through the Regulation of HAS2 Activity in Human Aortic Smooth Muscle Cells (2011)
• Quantitative analysis of transient and sustained transforming growth factor-beta signaling dynamics (2011)
• Transforming growth factor β promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin (2010)
• Immortalized keratinocytes from Epidermolytic Ichthyosis-patients reproduce the disease phenotype in vitro (2010)
• The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination (2010)
• PARP-1 attenuates Smad-mediated transcription (2010)
• Integrins open the way to epithelial-mesenchymal transitions (2010)
• Proteomic identification of CD44 interacting proteins (2010)
• Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines (2009)
• Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition (2009)
• Growth factor regulation of hyaluronan metabolism in tumor progression (2009)
• Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom (2009)
• Control of transforming growth factor beta signal transduction by small GTPases (2009)
• Regulating the stability of TGFβ receptors and Smads (2009)
• The regulation of TGFβ signal transduction (2009)
• A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF‑β mediated epithelial–mesenchymal transition (2009)
• Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis (2008)
• Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis (2008)
• TGFβ induces SIK to negatively regulate type I receptor kinase signaling (2008)
• TGF-beta Targets PAX3 to Control Melanocyte Differentiation (2008)
• Dynamic control of TGF-beta signaling and its links to the cytoskeleton (2008)
• HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition (2008)
• Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts (2007)
• Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells (2007)
• Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression (2007)
• Notch signaling is necessary for epithelial growth arrest by TGF-beta (2007)
• Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer (2007)
• Functional role of Meox2 during the epithelial cytostatic response to TGF-beta (2007)
• Operational criteria for selecting a cDNA microarray data normalization algorithm (2006)
• A new twist in Smad signaling (2006)
• The mechanism of nuclear export of smad3 involves exportin 4 and Ran (2006)
• Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition (2006)
• Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases (2005)
• Non-Smad TGF-{beta} signals (2005)
• Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21Waf1/Cip1 (2005)
• Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner. (2005)
• TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition (2005)
• Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4 (2003)
• Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses (2003)
• Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells (2003)
• Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation (2003)
• Differential ubiquitination defines the functional status of the tumor suppressor Smad4 (2003)
• Ecsit-ement on the crossroads of Toll and BMP signal transduction (2003)
• The nuts and bolts of IRF structure (2003)
• Engagement of activin and bone morphogenetic protein signaling pathway Smad proteins in the induction of inhibin B production in ovarian granulosa cells (2002)
• PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4 (2002)
• The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter (2002)
• Smad signalling network (2002)
• From mono- to oligo-Smads (2002)
• Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation (2002)
• TGF-beta signaling from a three-dimensional perspective (2002)
• Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes (2002)
• cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C) (2001)
• Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner (2001)
• Smad regulation in TGF-beta signal transduction (2001)
• Glutamine deprivation alters TGF-β signaling in hepatocellular carcinoma
• SIK and Smurf2 cooperate to downregulate the TGF-β type I receptor
• TGF-β induces cholesterol accumulation to regulate the fate of tumor-derived extracellular vesicles
• The non-coding MIR100HG RNA mediates cytostatic responses of epithelial cells to transforming growth factor β
• TGFβ signaling down-regulates LINC00707 to inhibit inflammatory responses
• SNAI2 knockout induces metabolic and cell cycle changes in breast cancer cells
• SNAI1 and SMAD/TGF-β signals antagonize FOXA1 to control PSD4/EFA6B expression and couple integrin-mediated adhesion to endocytic fate in triple-negative breast cancer cells
• Epigenetic coupling of transcription factor CXXC5 regulates stemness genes in glioblastoma
• The liver kinase B1 inhibits transforming growth factor β signaling during mammary epithelial morphogenesis

Böcker

• TGF-beta in Human Disease (2013)

Kapitel

• Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β (2016)
• Growth factor regulation of hyaluronan deposition in malignancies. (2009)
• Epithelial-mesenchymal transition as a mechanism of metastasis (2009)
• Cancer-associated fibroblasts and the role of TGFbeta (2008)
• TGF-beta and Smad signaling in transcriptome reprogramming during EMT (2008)
• TGFß/Smad signaling in epithelial to mesenchymal transition (2006)