Junhao Li
Postdoktor vid Institutionen för fysik och astronomi; Röntgenfysik
- E-post:
- junhao.li@physics.uu.se
- Besöksadress:
- Ångströmlaboratoriet, Lägerhyddsvägen 1
- Postadress:
- Box 516
751 20 UPPSALA
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Kort presentation
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Computational modeling with deep cooperation with experiments focused on PET tracers (Positron Emission Tomography) for the early diagnose of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Corticobasal Degeneration (CBD).
In silico multiscale modeling of plant glycosyltransferase focusing on sugar and substrate selectivity.
Nyckelord
- binding free energy calculations
- molecular dynamics
- quantum chemical calculations
- tracer protein binding
Publikationer
Senaste publikationer
- Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3 (2024)
- Characterization and protein engineering of glycosyltransferases for the biosynthesis of diverse hepatoprotective cycloartane-type saponins in Astragalus membranaceus (2023)
- A highly selective C-rhamnosyltransferase from Viola tricolor and insights into its mechanisms (2023)
- Insight into the Binding of First- and Second-Generation PET Tracers to 4R and 3R/4R Tau Protofibrils (2023)
- In Silico and In Vitro Study towards the Rational Design of 4,4′-Disarylbisthiazoles as a Selective α-Synucleinopathy Biomarker (2023)
Alla publikationer
Artiklar
- Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3 (2024)
- Characterization and protein engineering of glycosyltransferases for the biosynthesis of diverse hepatoprotective cycloartane-type saponins in Astragalus membranaceus (2023)
- A highly selective C-rhamnosyltransferase from Viola tricolor and insights into its mechanisms (2023)
- Insight into the Binding of First- and Second-Generation PET Tracers to 4R and 3R/4R Tau Protofibrils (2023)
- In Silico and In Vitro Study towards the Rational Design of 4,4′-Disarylbisthiazoles as a Selective α-Synucleinopathy Biomarker (2023)
- Insights into the missing apiosylation step in flavonoid apiosides biosynthesis of Leguminosae plants (2023)
- Toward Novel [18F]Fluorine-Labeled Radiotracers for the Imaging of α-Synuclein Fibrils (2022)
- Dissecting the Binding Profile of PET Tracers to Corticobasal Degeneration Tau Fibrils (2021)
