Tatjana Haitina
Forskare vid Institutionen för organismbiologi; Evolution och utvecklingsbiologi
- E-post:
- tatjana.haitina@ebc.uu.se
- Besöksadress:
- Evolutionsbiologiskt Centrum EBC Norbyv. 18A
- Postadress:
- Norbyv. 18A
752 36 UPPSALA
- ORCID:
- 0000-0002-8754-5534
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Kort presentation
Regulatory mechanisms and 3D organisation of skeletal tissues during development and evolution of vertebrates
The main research focus of my group is to investigate how genes and regulatory DNA contribute to the 3D organization of tissues during vertebrate development and evolution with a specific focus on skeletal joints, as well as connective and mineralized tissues.
Nyckelord
- 3d microstructure of mineralized and soft tissues
- crispr-cas9 genome editing
- development and evolution
- molecular evolution of genes and regulatory sequences
- zebrafish
Publikationer
Senaste publikationer
- Evolutionary Genomics of Odontode Tissues (2023)
- Enhanced contrast synchrotron X-ray microtomography for describing skeleton-associated soft tissue defects in zebrafish mutants (2023)
- Ancient vertebrate dermal armor evolved from trunk neural crest (2023)
- A novel cis-regulatory element drives early expression of Nkx3.2 in the gnathostome primary jaw joint (2022)
- The role of Gdf5 in the development of the zebrafish fin endoskeleton (2022)
Alla publikationer
Artiklar
- Enhanced contrast synchrotron X-ray microtomography for describing skeleton-associated soft tissue defects in zebrafish mutants (2023)
- Ancient vertebrate dermal armor evolved from trunk neural crest (2023)
- A novel cis-regulatory element drives early expression of Nkx3.2 in the gnathostome primary jaw joint (2022)
- The role of Gdf5 in the development of the zebrafish fin endoskeleton (2022)
- The Role of Gdf5 in the Development of the Zebrafish Fin Endoskeleton (2022)
- Evolution of Matrix Gla and Bone Gla Protein Genes in Jawed Vertebrates (2021)
- The broad role of Nkx3.2 in the development of the zebrafish axial skeleton (2021)
- Reconstruction of the Carbohydrate 6-O Sulfotransferase Gene Family Evolution in Vertebrates Reveals Novel Member, CHST16, Lost in Amniotes (2020)
- zOPT: an open source optical projection tomography system and methods for rapid 3D zebrafish imaging (2020)
- Skeletal Mineralization in Association with Type X Collagen Expression Is an Ancestral Feature for Jawed Vertebrates (2019)
- Vascularization and odontode structure of a dorsal ridge spine of Romundina stellina Ørvig 1975 (2017)
- mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts (2016)
- Nematodes join the family of chondroitin sulfate-synthesizing organisms (2016)
- The Orphan G Protein-Coupled Receptor Gene GPR178 Is Evolutionary Conserved and Altered in Response to Acute Changes in Food Intake (2015)
- The Ndst Gene Family in Zebrafish (2015)
- Chondroitin / Dermatan Sulfate Modification Enzymes in Zebrafish Development (2015)
- New genomic and fossil data illuminate the origin of enamel (2015)
- The genome of Callorhinchus and the fossil record (2014)
- Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development (2013)
- GPR162 is expressed in the hypothalamus and is involved in food intake related behaviour (2011)
- The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus (2011)
- The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents (2009)
- Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat (2008)
- Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes (2007)
- High diversity in functional properties of melanocortin 1 receptor (MC1R) in divergent primate species is more strongly associated with phylogeny than coat color (2007)
- Further evidence for ancient role of ACTH peptides at melanocortin (MC) receptors; pharmacology of dogfish and lamprey peptides at dogfish MC receptors (2007)
- Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family (2007)
- The evolutionary history and tissue mapping of GPR123 (2007)
- Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system (2006)
- Gene structure of the goldfish agouti-signaling protein: (2005)
- Pharmacological characterization of melanocortin receptors in fish suggests an important role for ACTH (2005)
- Differential regulation of nuclear receptors, neuropeptides and peptide hormones in the hypothalamus and pituitary of food restricted rats (2005)
- Unusual genomic structure (2005)
- Evolutionary conservation of the structural, pharmacological, and genomic characteristics of the melanocortin receptor subtypes (2005)
- Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes (2004)
- The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs (2004)
- Cloning of two melanocortin (MC) receptors in spiny dogfish (2004)
- The melanocortin receptor subtypes in chicken have high preference to ACTH-derived peptides (2004)
- High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3 (2003)
- Distinct cis-regulatory elements drive prox1a expression in specific lymphatic vascular beds
- An evolutionarily conserved cis-regulatory element of nkx3.2 drives jaw joint-specific expression in zebrafish
- The Broad Role of Nkx3.2 in the Development of the Zebrafish Axial Skeleton
Böcker
Kapitel
- Evolutionary Genomics of Odontode Tissues (2023)
- Chapter 8 Neural Crest in Fossil Vertebrates: (2020)
- Utvecklingsbiologi- (2018)
Konferenser
