Johanna Larsson
Forskare vid Institutionen för läkemedelskemi; Preparativ läkemedelskemi
- E-post:
- johanna.larsson@scilifelab.uu.se
- Besöksadress:
- Uppsala Biomedicinska Centrum, BMC, Husarg. 3
- Postadress:
- Box 574
751 23 UPPSALA
- ORCID:
- 0000-0002-7676-6331
Mer information visas för dig som medarbetare om du loggar in.
Kort presentation
I’m an organic chemist working at the SciLifeLab Drug Discovery and Development platform (SciLifeLab DDD) in a team of chemists and biologists. The aim of the platform is to start from academic discoveries and work together with Swedish PI’s to progress drug development projects towards a pre-clinical proof-of-concept. My role is to design and synthesize novel drug candidates in the Hit2Lead – Lead ID phases.
Biografi
2016 -
Research Scientist, SciLifeLab Drug Discovery and Development platform (DDD)
The aim of the SciLifeLab DDD platform is to start from academic discoveries and work together with Swedish PI’s to develop small molecule and antibody leads towards a pre-clinical proof-of-concept.
The SciLifeLab DDD team consists of chemists and biologists with expertise within e.g. drug design, ADME, toxicology, biochemical and cellular screening, protein expression and crystallization, in-vitro and system pharmacology.
My role is to design and synthesize novel drug candidates in the Hit2Lead – Lead ID phases.
https://www.scilifelab.se/platforms/ddd
2014 - 2016
Research Scientist, OnTarget Chemistry / Recipharm OT Chemistry
Contract research organization, Uppsala
2008 - 2013
PhD in Organic Chemistry, Stockholm University
Development of new transition metal-catalyzed organic transformations and detailed mechanistic investigations in Prof. Kálmán Szabó’s research group
2007
Master of Science in Chemistry, Lund University
Publikationer
Senaste publikationer
- Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability (2020)
- 2-amino-1,3,4-thiadiazine and 2-amino-1,3,4-oxadiazine based antifungal agents (2017)
- Selective Activation of Arylboronate or Aryne Reactivity as a Versatile Postfunctionalization Strategy (2016)
- Regio- and Stereoselective Allylic Trifluoromethylation and Fluorination using CuCF3 and CuF Reagents. (2013)
- Mechanistic Investigation of the Palladium-Catalyzed Synthesis of Allylic Silanes and Boronates from Allylic Alcohols. (2013)
Alla publikationer
Artiklar
- Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability (2020)
- Selective Activation of Arylboronate or Aryne Reactivity as a Versatile Postfunctionalization Strategy (2016)
- Regio- and Stereoselective Allylic Trifluoromethylation and Fluorination using CuCF3 and CuF Reagents. (2013)
- Mechanistic Investigation of the Palladium-Catalyzed Synthesis of Allylic Silanes and Boronates from Allylic Alcohols. (2013)
- Palladium-Catalyzed Oxidative Allylic C-H Silylation. (2011)
- Asymmetric baker's yeast reductions of bridgehead-substituted bicyclo[2.2.2]octane-2,6-dione derivatives followed by conversion into catalytically active BODOLs for the diethylzinc addition to benzaldehyde. (2010)
- Pincer Complex-Catalyzed Redox Coupling of Alkenes with Iodonium Salts via Presumed Palladium(IV) Intermediates. (2009)
Patent
