Organisation and staff

Diarmaid Hughes

professor at Department of Medical Biochemistry and Microbiology, Microbiology-Immunology; Diarmaid Hughes

Email:
diarmaid.hughes[AT-sign]imbim.uu.se
Telephone:
+4618-471 4507
Fax:
018-471 4673
Visiting address:
Uppsala biomedicinska centrum BMC, Husarg. 3
75237 UPPSALA
Postal address:
Box 582
751 23 UPPSALA

Short presentation

I am interested in bacterial genetics and evolution, including the evolution of resistance to antibiotics, but my research interests are broader.

If you would like to do a project in my group (for example a masters exam project) please contact me directly by email. I am looking for people who are interested in problem solving, and in basic science (we are NOT a clinical microbiology lab), and bacterial genetics, with very good academic qualifications. Contact: diarmaid.hughes@imbim.uu.se

My courses

Biography

Our main research interests are in bacterial genetics and evolution, including the evolution of antibiotic resistance, the development of novel Gram-negative antibiotics. In studying the evolution of antibiotic resistance, an in-depth understanding of the selection processes and evolutionary principles behind fitness/resistance trade-offs is required for developing methodologies capable of suppressing the growth or spread of resistant bacteria. In this context discovering new drugs or drug targets is very important.

We are studying the evolution of resistance to antimicrobial drugs, with a particular focus on the fluoroquinolones. Questions include how resistance development impacts on bacterial fitness and how bacteria respond by compensatory evolution. The step-wise nature of antibiotic resistance evolution, and the co-evolution of resistance to multiple antibiotics are being studied.

We also study basic questions in bacterial genetics. Among the specific questions are the importance of codon usage bias, and the significance of the organisation of genes and operons on the bacterial chromosome - why are particular operons where they are? Would it make a difference if they were placed elsewhere on the genome? We have the technology to address these fundamental questions experimentally. Related question address the rates and mechanisms of bacterial genome rearrangements associated with repetitive sequences.

If you would like to make a project in my group you should be interested in problem solving (we are NOT a clinical microbiology lab), and it is an advantage to be bright and smart. An engineering background would be good, also being comfortable with numbers, modelling, computers and data analysis. You should have a good academic CV, be interested in basic science, and be prepared to work seriously and hard.

Contact me by email with your CV: diarmaid.hughes@imbim.uu.se

My publication list can be found on Google Scholar (more up to date than DIVA, and actually contains most of my publications): 

https://scholar.google.com/citations?hl=en&user=rSid04wAAAAJ&pagesize=100&view_op=list_works&sortby=pubdate

 

Publications

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