Fredrik Clausen
Senior research engineer at Institutionen för medicinska vetenskaper; Neurokirurgi
- Telephone:
- +46 18 471 47 01
- E-mail:
- fredrik.clausen@neuro.uu.se
- Visiting address:
- Akademiska sjukhuset, ingång 85 2 tr
- Postal address:
- Akademiska sjukhuset, ing 85 2 tr
751 85 UPPSALA
- Academic merits:
- MD PhD
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Short presentation
My research involves in vivo models of TBI in order to study the effects of free radicals, immune cells and inflammatory proteins in the disease.
I teach neuro-, cell- and molecularbiology and laboratory animal science.
Keywords
- edema
- inflammation
- tbi
Publications
Recent publications
- Impaired oligodendrogenesis in the white matter of aged mice following diffuse traumatic brain injury (2024)
- A Dedicated 21-Plex Proximity Extension Assay Panel for High-Sensitivity Protein Biomarker Detection Using Microdialysis in Severe Traumatic Brain Injury (2023)
- Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits (2022)
- Interleukin-1 Beta Neutralization Attenuates Traumatic Brain Injury-Induced Microglia Activation and Neuronal Changes in the Globus Pallidus (2020)
- Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma (2020)
All publications
Articles
- Impaired oligodendrogenesis in the white matter of aged mice following diffuse traumatic brain injury (2024)
- A Dedicated 21-Plex Proximity Extension Assay Panel for High-Sensitivity Protein Biomarker Detection Using Microdialysis in Severe Traumatic Brain Injury (2023)
- Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits (2022)
- Interleukin-1 Beta Neutralization Attenuates Traumatic Brain Injury-Induced Microglia Activation and Neuronal Changes in the Globus Pallidus (2020)
- Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma (2020)
- Acute Inflammatory Biomarker Responses to Diffuse Traumatic Brain Injury in the Rat Monitored by a Novel Microdialysis Technique (2019)
- Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care (2019)
- Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord (2019)
- Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease (2019)
- Reduced Intracranial Pressure After Treatment With Anti-Secretory Factor 16 In A Rat Model Of Traumatic Brain Injury (2018)
- Neutralization of Interleukin-1 beta following Diffuse Traumatic Brain Injury in the Mouse Attenuates the Loss of Mature Oligodendrocytes (2018)
- A Dedicated 21-Plex Pea Panel For High-Sensitive Protein Biomarker Detection Using Micro-Dialysis In Traumatic Brain Injury (2018)
- Biomechanical analysis of fluid percussion model of brain injury (2018)
- Asymmetric Hindlimb Motor Response To Focal Traumatic Brain Injury Is Controlled By Side-Specific Opioid Mechanism (2018)
- Intranasal Administration of the Antisecretory Peptide AF-16 Reduces Edema and Improves Cognitive Function Following Diffuse Traumatic Brain Injury in the Rat (2017)
- Diffuse traumatic brain injury in the mouse induces a transient proliferation of oligodendrocyte progenitor cells in injured white matter tracts (2017)
- Diffuse traumatic axonal injury in mice induces complex behavioural alterations that are normalized by neutralization of interleukin-1β (2016)
- Direct imaging of elemental distributions in tissue sections by laser ablation mass spectrometry (2016)
- Extracellular Ezrin - a Novel Biomarker for Traumatic Brain Injury (2015)
- Novel Microdialysis Method to Study The Acute Cytokine Response to Diffuse Traumatic Brain Injury in the Rat (2014)
- Combination of growth factor treatment and scaffold deposition following traumatic brain injury has only a temporary effect on regeneration (2014)
- Refined microdialysis method for protein biomarker sampling in acute brain injury in the neurointensive care setting (2014)
- Escalated handling of young C57BL/6 mice results in altered Morris water maze performance (2014)
- Cerebral microdialysis for protein biomarker monitoring in the neurointensive care setting - a technical approach (2014)
- Combination of Growth Factor Treatment and Scaffold Deposition Following Experimental Traumatic Brain Injury Show a Temporary Effect on Cellular Regeneration (2013)
- Identification of Injury Specific Proteins in a Cell Culture Model of Traumatic Brain Injury (2013)
- Hyponatremia augments kainic-acid induced status epilepticus in the mouse (2013)
- Hyponatremia augments kainic-acid induced status epilepticus in the mouse (2013)
- The free radical scavenger S-PBN significantly prolongs DSG-mediated graft survival in experimental xenotransplantation (2012)
- Exploring a new approach to treating brain injury (2012)
- Interstitial F2-Isoprostane 8-Iso-PGF2α As a Biomarker of Oxidative Stress after Severe Human Traumatic Brain Injury (2012)
- Functional and Histological Outcome after Focal Traumatic Brain Injury Is Not Improved in Conditional EphA4 Knockout Mice (2012)
- Facilitated assessment of tissue loss following experimental traumatic brain injury (2012)
- Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice (2012)
- Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice (2012)
- Endogenous free radical production by NADPH oxidase 2 contributes to the secondary injury cascade after traumatic brain injury in mice (2012)
- Cerebral glucose metabolism after traumatic brain injury in the rat studied by C-13-glucose and microdialysis (2011)
- Neutralization of interleukin-1 beta reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice (2011)
- Genetic Deletion and Pharmacological Inhibition of Nogo-66 Receptor Impairs Cognitive Outcome after Traumatic Brain Injury in Mice (2010)
- Neutralization of interleukin-1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice (2009)
- Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice (2009)
- Nandrolone decanoate administration elevates hippocampal prodynorphin mRNA expression and impairs Morris water maze performance in male rats (2009)
- Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice (2009)
- Grafted neural progenitors migrate and form neurons after experimental traumatic brain injury (2009)
- The nitrone free radical scavenger NXY-059 is neuroprotective when administered after traumatic brain injury in the rat (2008)
- T Lymphocyte trafficking (2007)
- Oxygen free radical-dependent activation of extracellular signal-regulated kinase mediates apoptosis-like cell death after traumatic brain injury (2004)
- Reduced loss of mature Oligodendrocytes following Diffuse Traumatic Brain Injury in the mouse by Neutralization of Interleukin-1β