Peter Bergsten
Professor at Institutionen för medicinsk cellbiologi; Forskargrupp Peter Bergsten
- Telephone:
- +46 18 471 49 23
- Mobile phone:
- +46 70 870 22 10
- Fax:
- +46 18 471 40 59
- E-mail:
- Peter.Bergsten@mcb.uu.se
- Visiting address:
- BMC
Husargatan 3
751 23 Uppsala - Postal address:
- Box 571
751 23 UPPSALA
Affiliated Researcher at Institutionen för kvinnors och barns hälsa; Pediatrisk inflammations- och metabolismforskning samt barnhälsa
- Telephone:
- +46 18 471 49 23
- Mobile phone:
- +46 70 870 22 10
- E-mail:
- peter.bergsten@kbh.uu.se
- Visiting address:
- MTC-huset, Dag Hammarskjölds väg 14B, 1 tr
752 37 Uppsala - Postal address:
- Akademiska sjukhuset
751 85 UPPSALA - Available:
- barnspecialistmottagning, forskningsavd barn
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Publications
Recent publications
- Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells (2024)
- Screening for inflammatory markers identifies IL18-Rα as a potential link between exenatide and its anti-inflammatory effect (2023)
- Adolescents with obesity treated with exenatide maintain endogenous GLP-1, reduce DPP-4, and improve glycemic control (2023)
- Low Fasting Concentrations of Glucagon in Patients with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency (2023)
- Metformin restores prohormone processing enzymes and normalizes aberrations in secretion of proinsulin and insulin in palmitate‐exposed human islets (2023)
All publications
Articles
- Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells (2024)
- Screening for inflammatory markers identifies IL18-Rα as a potential link between exenatide and its anti-inflammatory effect (2023)
- Adolescents with obesity treated with exenatide maintain endogenous GLP-1, reduce DPP-4, and improve glycemic control (2023)
- Low Fasting Concentrations of Glucagon in Patients with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency (2023)
- Metformin restores prohormone processing enzymes and normalizes aberrations in secretion of proinsulin and insulin in palmitate‐exposed human islets (2023)
- Metformin Can Attenuate Beta-Cell Hypersecretion-Implications for Treatment of Children with Obesity (2023)
- High levels of FSH before puberty are associated with increased risk of metabolic syndrome during pubertal transition (2022)
- Deviating glucose results in an international dual-center study. A root cause investigation (2022)
- Single Point Insulin Sensitivity Estimator in Pediatric Non-Alcoholic Fatty Liver Disease (2022)
- Association between alanine aminotransferase as surrogate of fatty liver disease and physical activity and sedentary time in adolescents with obesity (2022)
- Sedentary time has a stronger impact on metabolic health than moderate to vigorous physical activity in adolescents with obesity (2022)
- Association between Metabolic Syndrome Diagnosis and the Physical Activity-Sedentary Profile of Adolescents with Obesity (2022)
- Determinants of hyperglucagonemia in pediatric non-alcoholic fatty liver disease (2022)
- Obesity in adolescents associated with vascular aging - a study using ultra-high-resolution ultrasound (2022)
- Altered mitochondrial metabolism in peripheral blood cells from patients with inborn errors of β-oxidation (2022)
- Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions (2022)
- The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis (2022)
- Prevalence of different states of glucose intolerance in Sri Lankan children and adolescents with obesity and its relation to other comorbidities. (2021)
- Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK (2021)
- Evaluation of fasting plasma insulin and proxy measurements to assess insulin sensitivity in horses (2021)
- Impaired HMG-CoA reductase activity caused by genetic variants or statin exposure (2021)
- Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka (2021)
- Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity. (2020)
- A 6-month randomized, double-blind, placebo-controlled trial of weekly exenatide in adolescents with obesity (2020)
- The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells (2020)
- Fully convolutional networks for automated segmentation of abdominal adipose tissue depots in multicenter water–fat MRI (2019)
- Brown adipose tissue estimated with the magnetic resonance imaging fat fraction is associated with glucose metabolism in adolescents (2019)
- Hyperglucagonemia in youth is associated with high plasma free fatty acids, visceral adiposity and impaired glucose tolerance (2019)
- Developmental exposure to a very low dose of bisphenol A induces persistent islet insulin hypersecretion in Fischer 344 rat offspring (2019)
- Oleate increase neutral lipid accumulation, cellular respiration and rescues palmitate-exposed GLP-1 secreting cells by reducing ceramide-induced ROS (2019)
- Glucose Appearance Rate Rather than the Blood Glucose Concentrations Explains Differences in Postprandial Insulin Responses between Wholemeal Rye and Refined Wheat Breads-Results from A Cross-Over Meal Study (2019)
- The protein synthesis inhibitor brusatol normalizes high-fat diet-induced glucose intolerance in male C57BL/6 mice (2019)
- Assessment of Nutritional Status in Sri Lankan Children (2019)
- Mechanisms of beneficial effects of metformin on fatty acid-treated human islets (2018)
- Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner (2018)
- Palmitate-Induced Insulin Hypersecretion and Later Secretory Decline Associated with Changes in Protein Expression Patterns in Human Pancreatic Islets (2018)
- The initial rise in GIP secretion during OGTT correlates with the initial suppression of glucagon secretion in adolescents with obesity and type 2 diabetes (2018)
- Identification of early biological changes in palmitate-treated isolated human islets. (2018)
- High DPP-4 concentrations in adolescents are associated with low intact GLP-1 (2018)
- Metformin restores insulin secretion from palmitate-treated human islets by normalising mitochondrial metabolism and reducing ER stress and apoptosis (2017)
- Childhood adiposity and risk of type 1 diabetes (2017)
- GLP-1 analogue recovers impaired insulin secretion from human islets treated with palmitate via down-regulation of SOCS2 (2017)
- Exenatide Once Weekly Reduces Weight, Liver Fat And 2-Hour Postprandial Glucose In Obese Adolescents (2017)
- Effect of Glucose Load on the Incretin Response (GLP-1) in obese Adolescents compared to the normal-weight Adolescents (2017)
- Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion (2017)
- EndoC-beta H1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium (2017)
- Automated segmentation of human cervical-supraclavicular adipose tissue in magnetic resonance images (2017)
- TNFSF14 (2017)
- Association Between Non-Alcoholic Fatty Liver Disease (NAFLD) and Iron Metabolism in Obese Children and Adolescents (2017)
- Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism (2017)
- Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity (2017)
- Fatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms (2016)
- Eating Behavior In Swedish And Austrian Children And Adolescents With Obesity (2016)
- Free fatty acids amplify basal secretion of both glucagon and insulin from isolated human islets at normoglycaemia via metabolic and FFAR1 dependent mechanism (2016)
- Hyperglucagonaemia is associated with elevated plasma triglycerides and increased visceral fat in children and adolescents (2016)
- Hyperglucagonemia is associated with a Increase of Plasma Triglycerides as well as visceral Fat Tissue in a pediatric Cohort (2016)
- Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes (2016)
- Branched-chain amino acids are associated with cardiometabolic risk profiles found already in lean, overweight and obese young (2016)
- Modification and Validation of the Triglyceride-to-HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus (2016)
- Oleate protects beta cells from the toxic effect of palmitate by restoring pro-survival pathways of the ER stress response (2016)
- Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response (2016)
- Initial hyperinsulinemia and subsequent beta-cell dysfunction is associated with elevated palmitate levels (2016)
- Role of PIAS1 in palmitate mediated beta cell dysfunction (2015)
- Development of Glucose Intolerance in Obese Children Studied in the Beta-Judo Cohort (2015)
- Role of the AMP kinase in cytokine-induced human EndoC-beta H1 cell death (2015)
- Palmitate stimulates insulin secretion by enhancing mitochondrial respiration via intracellular metabolism and FFAR1 signalling (2015)
- Free fatty acid receptor 1 (FFAR1/GPR40) signaling affects insulin secretion by enhancing mitochondrial respiration during palmitate exposure (2015)
- Magnetic resonance imaging cooling–reheating protocol indicates decreased fat fraction via lipid consumption in suspected brown adipose tissue (2015)
- Palmitate-induced impairments of beta-cell function are linked with generation of specific ceramide species via acylation of sphingosine (2015)
- Early Adiposity Rebound and its Association with Obesity and Neuropsychiatric Disorders (2015)
- Active GLP-1 but not insulin, glicentin or glucagon predicts the 2-hour OGTT glucose value in obese children (2015)
- Deep Subcutaneous Adipose Tissue Correlates with Accentuated Insulin Secretion and Poor Insulin Sensitivity in Obese Children and Adolescents (2015)
- Pancreatic Fat is Associated with Metabolic Syndrome and Visceral Adipose Tissue but not Beta-Cell Function or Body Mass Index in Paediatric Obesity (2015)
- Dipeptidyl Peptidase-4 is Associated with Elevated Liver Enzymes, Impaired Glucose Tolerance and Lowered Glucagon-Like Peptide-1 in Obese Children (2015)
- Uppsala Longitudinal Study of Childhood Obesity (2014)
- Functional differences between aggregated and dispersed insulin-producing cells (2013)
- Signaling in Insulin-Secreting MIN6 Pseudoislets and Monolayer Cells (2013)
- FFAR1 is involved in both the acute and chronic effects of palmitate on insulin secretion (2013)
- FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion (2013)
- Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides (2013)
- Hög tid att söka till nya MD/PhD-programmet vid Uppsala universitet (2012)
- Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells (2011)
- UPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid (2011)
- Palmitate-induced changes in protein expression of insulin secreting INS-1E cells (2010)
- Pseudoislets as primary islet replacements for research Report on a symposium at King's College London, London UK (2010)
- Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate (2010)
- Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing beta-cells (2010)
- Rapid alternations in DNA methylation patterns in insulin-producing beta cells correlate with changes in ambient glucose levels (2010)
- Islet protein profiling (2009)
- Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms (2009)
- Apoptotic, Regenerative, And Immune-Related Signaling in Human Islets from Type 2 Diabetes Individuals (2009)
- Role of MAPK in apolipoprotein CIII-induced apoptosis in INS-1E cells (2009)
- Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion (2009)
- Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids (2008)
- AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels (2008)
- Diazoxide-induced beta-cell rest reduces endoplasmic reticulum stress in lipotoxic beta-cells (2008)
- Glucolipotoxicity in INS-1E cells is counteracted by carnitine palmitoyltransferase 1 over-expression (2008)
- Serum protein patterns in newly diagnosed type 2 diabetes mellitus--influence of diabetic environment and family history of diabetes. (2008)
- Plasma proteome changes in subjects with Type 2 diabetes mellitus with a low or high early insulin response (2008)
- Evaluation of the SELDI-TOF MS technique for protein profiling of pancreatic islets exposed to glucose and oleate (2007)
- Oxo-4-methylpentanoic acid directs the metabolism of GABA into the Krebs cycle in rat pancreatic islets (2006)
- Mitochondrial protein patterns correlating with impaired insulin secretion from INS-1E cells exposed to elevated glucose concentrations (2006)
- Protein profiling of pancreatic islets (2006)
- Glucose-induced changes of multiple mouse islet proteins analysed by two-dimensional gel electrophoresis and mass spectrometry. (2005)
- Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. (2005)
- Regulation of 11beta-hydroxysteroid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans. (2005)
- Regulation of 11beta-hydroxysterioid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans (2004)
- Phenotyping of individual pancreatic islets locates genetic defects instimulus secretion coupling to Niddm1i within the major diabetes locus inGK rats. (2001)
- Glucose-regulated pulsatile insulin release from mouse islets via the K(ATP) channel-independent pathway. (2001)
- Appearance of glucose-induced insulin release in fetal rat β-cells (1998)
- In vitro regulation of insulin release and biosynthesis of fetal rat pancreatic cells explanted on pregnancy day 16. (1997)
- Screening of inflammatory markers finds hepatocyte growth factor to be associated with weight gain in children and adolescents with obesity
- Role of mitochondrial metabolism and fission protein DRP-1 in palmitate-induced glucagon secretion