Suparna Sanyal
Professor at Institutionen för cell- och molekylärbiologi; Molekylärbiologi
- Telephone:
- +46 18 471 42 20
- Mobile phone:
- +46 73 780 64 26
- Fax:
- +46 18 471 42 62
- E-mail:
- Suparna.Sanyal@icm.uu.se
- Visiting address:
- Husargatan 3
752 37 Uppsala - Postal address:
- Box 596
751 24 Uppsala
Professor at Institutionen för cell- och molekylärbiologi; Uppsala RNA Research Centre - URRC
- Telephone:
- +46 18 471 42 20
- Mobile phone:
- +46 73 780 64 26
- E-mail:
- Suparna.Sanyal@icm.uu.se
- Visiting address:
- Husargatan 3
752 37 Uppsala - Postal address:
- Box 596
751 24 Uppsala
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Short presentation
Prof. Suparna Sanyal is a molecular biologist who explores in-depth mechanisms of protein synthesis and protein folding using fast kinetics. Sanyal is interested in solving problems related to antibiotic resistance in pathogenic bacteria. Sanyal lab is also investigating how protein folding activity of the ribosome (PFAR) influences misfolding diseases e.g. prion diseases in higher mammals. Sanyal frequently uses structural biology (X-ray Cryst., NMR and Cryo-EM) as complementary tools.
Keywords
- africa journal of evangelical theology
- amyloid
- antibiotic resistance
- prion
- protein folding
- protein synthesis
Publications
Recent publications
- Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis (2023)
- Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria (2023)
- Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome (2023)
- Lamotrigine compromises the fidelity of initiator tRNA recruitment to the ribosomal P-site by IF2 and the RbfA release from 30S ribosomes in Escherichia coli (2023)
- p53 Isoforms as Cancer Biomarkers and Therapeutic Targets (2022)
All publications
Articles
- Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis (2023)
- Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria (2023)
- Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome (2023)
- Lamotrigine compromises the fidelity of initiator tRNA recruitment to the ribosomal P-site by IF2 and the RbfA release from 30S ribosomes in Escherichia coli (2023)
- p53 Isoforms as Cancer Biomarkers and Therapeutic Targets (2022)
- Real-time measurements of aminoglycoside effects on protein synthesis in live cells (2021)
- Repurposing tRNAs for nonsense suppression (2021)
- Kinetic Analysis Suggests Evolution of Ribosome Snecificity in Modern Elongation Factor-Tus from "Generalist" Ancestors (2021)
- Cotranslational recruitment of ribosomes in protocells recreates a translocon-independent mechanism of proteorhodopsin biogenesis (2021)
- Optimization of a fluorescent-mRNA based real-time assay for precise kinetic measurements of ribosomal translocation (2021)
- Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin (2021)
- GGQ methylation enhances both speed and accuracy of stop codon recognition by bacterial class-I release factors (2021)
- Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence (2020)
- Selective translation by alternative bacterial ribosomes (2020)
- Ribosomal RNA Modulates Aggregation of thePodosporaPrion Protein HET-s (2020)
- Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation (2020)
- Modulation of p53 and prion protein aggregation by RNA (2019)
- Inhibition of translation termination by small molecules targeting ribosomal release factors (2019)
- The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation (2019)
- RNA modulates aggregation of the recombinant mammalian prion protein by direct interaction (2019)
- Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-Tu(H84A) (2018)
- Complementary charge-based interaction between the ribosomal-stalk protein L7/12 and IF2 is the key to rapid subunit association (2018)
- Cryo-EM structure of Mycobacterium smegmatis ribosome reveals two unidentified ribosomal proteins close to the functional centers (2018)
- The enigmatic ribosomal stalk (2018)
- Catalytic O- to N-Alkyl Migratory Rearrangement (2018)
- p53 Isoforms and Their Implications in Cancer (2018)
- p53 Isoforms and Their Implications in Cancer (2018)
- Binding Characteristics of Anticancer Drug Doxorubicin with Two-Dimensional Graphene and Graphene Oxide (2018)
- Regulation of PfEMP1-VAR2CSA translation by a Plasmodium translation-enhancing factor (2017)
- Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein (2017)
- R213I mutation in release factor 2 (RF2) is one step forward for engineering an omnipotent release factor in bacteria Escherichia coli (2017)
- Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain. (2017)
- A genetically encoded fluorescent tRNA is active in live-cell protein synthesis (2017)
- Spatial Distribution and Ribosome-Binding Dynamics of EF-P in Live Escherichia coli (2017)
- New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R) (2017)
- Micrococcin P1-A bactericidal thiopeptide active against Mycobacterium tuberculosis (2016)
- Molecular mechanism of viomycin inhibition of peptide elongation in bacteria (2016)
- Fusidic Acid Targets Elongation Factor G in Several Stages of Translocation on the Bacterial Ribosome (2015)
- A conserved histidine in switch-II of EF-G moderates release of inorganic phosphate (2015)
- Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G (2015)
- Electronic structure and spectroscopic properties of 6-aminophenanthridine and its derivatives (2015)
- HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions (2015)
- Protein Folding Activity of the Ribosome (PFAR) (2014)
- Spectroscopic and DFT studies on 6-Aminophenanthridine and its derivatives provide insights in their activity towards ribosomal RNA (2014)
- Organization of Ribosomes and Nucleoids in Escherichia coli Cells during Growth and in Quiescence (2014)
- Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase (2014)
- Comprehensive Analysis of Stop Codon Usage in Bacteria and Its Correlation with Release Factor Abundance (2014)
- Characterizing an engineered release factor capable of reading all three stop codons (2014)
- Structure-Activity Relationship Study around Guanabenz Identifies Two Derivatives Retaining Antiprion Activity but Having Lost alpha 2-Adrenergic Receptor Agonistic Activity (2014)
- The Toll-Like Receptor Agonist Imiquimod Is Active against Prions (2013)
- Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1 (2013)
- The Antiprion Compound 6-Aminophenanthridine Inhibits the Protein Folding Activity of the Ribosome by Direct Competition (2013)
- Interaction of Nucleobases and Aromatic Amino Acids with Graphene Oxide and Graphene Flakes (2013)
- Mechanism and Rates of Exchange of L7/L12 between Ribosomes and the Effects of Binding EF-G (2012)
- Structure and function of FusB (2012)
- Mechanism of Elongation Factor-G-mediated Fusidic Acid Resistance and Fitness Compensation in Staphylococcus aureus (2012)
- Bacterial ribosome requires multiple L12 dimers for efficient initiation and elongation of protein synthesis involving IF2 and EF-G (2012)
- Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding (2011)
- Staphylococcus aureus elongation factor G - structure and analysis of a target for fusidic acid (2010)
- The Ribosomal Stalk Plays a Key Role in IF2-Mediated Association of the Ribosomal Subunits (2010)
- Ribosomes lacking protein S20 are defective in mRNA binding and subunit association (2010)
- A single-step method for purification of active His-tagged ribosomes from a genetically engineered Escherichia coli (2009)
- Recognition of aminoacyl-tRNA (2008)
- Protein Folding Activity of Ribosomal RNA Is a Selective Target of Two Unrelated Antiprion Drugs (2008)
- RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors (2007)
- The ribosomal stalk binds to translation factors IF2, EF-Tu, EF-G and RF3 via a conserved region of the L12 C-terminal domain (2007)
- Immobilized β-cyclodextrin polymer coupled to agarose gel properly refolding recombinant Staphylococcus aureus elongation factor-G in combination with detergent micelle (2006)
- Synthesis and biological evaluation of photoaffinity labeled fusidic acid analogues. (2006)
- A mild hydrophobic interaction chromatography involving polyethylene glycol immobilized to agarose media refolding recombinant Staphylococcus aureus elongation factor G (2005)
- Over expression of a tRNA(Leu) isoacceptor changes charging pattern of leucine tRNAs and reveals new codon reading. (2005)
- The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure. (2005)
- The end of the beginning: structural studies of ribosomal proteins (2000)
- Real-time measurements of aminoglycoside effects on protein synthesis in live cells
- Distribution of ribosomes in action and at rest in Escherichia coli: involvement of bacterial cytoskeleton
- An extended C-terminal tail of the ribosomal protein S13 modulates the speed of ribosomal translocation.
- Essential role of Histidine 92 in elongation factor-G in GTP hydrolysis and inorganic phosphate release during elongation of protein synthesis
- The compensatory mechanism of a naturally-evolved E167K RF2 counteracting the loss of RF1 in bacteria
Conferences
