Erik Sjögren
Researcher at Institutionen för farmaceutisk biovetenskap; Forskning; Translationell läkemedelsutveckling
- Telephone:
- +46 18 471 41 54
- E-mail:
- erik.sjogren@uu.se
- Visiting address:
- BMC, Husargatan 3
75124 Uppsala - Postal address:
- Box 591
75124 Uppsala
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Short presentation
Assoc. Prof. Erik Sjögren research focus is mechanistic and physiologically based modelling & simulation, i.e., physiologically based pharmacokinetic (PBPK), physiologically based biopharmaceutics modeling (PBBM) and quantitative system pharmacology (QSP), for predictions, translations and analyses of information and data across all phases in drug development.
Keywords
- biopharmaceutics
- drug delivery
- modeling and simulation
- pbbm
- pbpk
- pharmacokinetics
- physiologically based modeling
- qsp
Publications
Selection of publications
- Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project (2020)
- Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link (2019)
- Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences (2019)
- Mechanistic modelling of intestinal drug absorption (2018)
- In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma (2017)
- In Silico Modeling of Gastrointestinal Drug Absorption (2016)
- Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods (2015)
- Human in Vivo Regional Intestinal Permeability (2015)
- In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects (2014)
- In silico predictions of gastrointestinal drug absorption in pharmaceutical product development (2013)
Recent publications
- Understanding Statin-Roxadustat Drug–Drug-Disease Interaction Using Physiologically-Based Pharmacokinetic Modeling (2023)
- Physiologically based biopharmaceutics modeling of regional and colon absorption in humans (2023)
- Drug diffusion in biomimetic hydrogels (2022)
- Overview of authorized drug products for subcutaneous administration (2022)
- Physiological based pharmacokinetic and biopharmaceutics modelling of subcutaneously administered compounds - An overview of in silico models (2022)
All publications
Articles
- Understanding Statin-Roxadustat Drug–Drug-Disease Interaction Using Physiologically-Based Pharmacokinetic Modeling (2023)
- Physiologically based biopharmaceutics modeling of regional and colon absorption in humans (2023)
- Drug diffusion in biomimetic hydrogels (2022)
- Overview of authorized drug products for subcutaneous administration (2022)
- Physiological based pharmacokinetic and biopharmaceutics modelling of subcutaneously administered compounds - An overview of in silico models (2022)
- Does the choice of applied physiologically-based pharmacokinetics platform matter? (2022)
- Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study (2022)
- In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes (2021)
- Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project (2020)
- Intestinal absorption of BCS class II drugs administered as nanoparticles (2020)
- Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption (2020)
- Pulmonary drug absorption and systemic exposure in human (2020)
- Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery (2019)
- Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model (2019)
- Rat intestinal drug permeability (2019)
- Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia (2019)
- Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model (2019)
- Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link (2019)
- Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs? (2019)
- Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences (2019)
- Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions (2019)
- The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet-C exposed skin in healthy volunteers (2019)
- Single bead investigation of a clinical drug delivery system – a novel release mechanism (2018)
- The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs. (2018)
- Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport. (2018)
- Time-dependent effects on small intestinal transport by absorption-modifying excipients (2018)
- Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'" (2018)
- Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment (2018)
- Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis (2018)
- Jejunal absorption of aprepitant from nanosuspensions (2018)
- Mechanistic modelling of intestinal drug absorption (2018)
- Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies (2018)
- Clinical testing of three novel transient receptor potential cation channel subfamily V member 1 antagonists in a pharmacodynamic intradermal capsaicin model (2018)
- Applications of Clinically Relevant Dissolution Testing (2018)
- Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker 51Cr-EDTA (2017)
- A Model -Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition (2017)
- Computational fluid dynamics (CFD) studies of a miniaturized dissolution system (2017)
- In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation (2017)
- In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma (2017)
- Lipiodol does not affect the tissue distribution of intravenous doxorubicin infusion in pigs (2017)
- In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations (2017)
- Regional Intestinal Permeability in Rats (2017)
- Reply to "Comment on 'In Silico Modeling of Gastrointestinal Drug Absorption (2017)
- In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System (2016)
- Regional Intestinal Permeability in Dogs (2016)
- Regional Intestinal Permeability of Three Model Drugs in Human (2016)
- Assessment of Free Drug Concentration in Cyclodextrin Formulations Is Essential to Determine Drug Potency in Functional In Vitro Assays (2016)
- Excised segments of rat small intestine in Ussing chamber studies (2016)
- In Silico Modeling of Gastrointestinal Drug Absorption (2016)
- A miniaturized in vitro release method for investigating drug-release mechanisms (2015)
- Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods (2015)
- Concomitant intake of alcohol may increase the absorption of poorly soluble drugs (2015)
- Human in Vivo Regional Intestinal Permeability (2015)
- Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example (2014)
- Treatment of intermediate stage hepatocellular carcinoma (2014)
- The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs (2014)
- In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects (2014)
- Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs (2014)
- Pharmacokinetics of an Injectable Modified-Release 2-Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model (2014)
- In silico predictions of gastrointestinal drug absorption in pharmaceutical product development (2013)
- The pharmacokinetics and hepatic disposition of repaglinide in pigs (2012)
- Optimized Experimental Design for the Estimation of Enzyme Kinetic Parameters (2012)
- Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo (2012)
- Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment (2011)
- Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model (2010)
- Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix. (2009)
- The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km) (2009)
- Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
- Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population
- Physiologically Based Pharmacokinetics Modeling and Transporter Proteomics to Predict Systemic and Local Liver and Muscle Disposition of Statins
- Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions