Daniel Globisch
Professor at Institutionen för kemi - BMC; Analytisk kemi; Globisch grupp
- Telephone:
- +46 70 425 01 39, +46 18 471 36 30
- E-mail:
- daniel.globisch@kemi.uu.se
- Visiting address:
- Husargatan 3 (D5)
752 37 Uppsala - Postal address:
- Box 599
75124 Uppsala
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Short presentation
Professor with focus on Biomarker Discovery using techniques at the interface of Chemistry and Biology including Chemical Biology, Organic Chemistry, mass spectrometry-based investigation of human samples, and metabolomics-methodologies. Former SciLifeLab Fellow.
Keywords
- biomarker discovery
- bioorganic chemistry
- chemical biology
- gut microbiota
- mass spectrometry
- metabolomics
- microbiome
- organic chemistry
Biography
- 11/23 – present Uppsala University, Sweden; Full Professor
- 12/20 – 10/23 Uppsala University, Sweden; Associate Professor (tenured)
- 04/17 – 12/20 Uppsala University, Sweden; Associate Professor
- 08/15 – 04/17 Uppsala University, Sweden; Assistant Professor
- 04/11 – 08/15 The Scripps Research Institute, La Jolla, USA; PostDoc with Professor Kim D. Janda, Ph.D.
- 03/07 – 03/11 Ludwig-Maximilians-University Munich, Germany; PhD student with Professor Dr. Thomas Carell
- 04/06 – 01/07 & 04/05 – 07/05 University of Southern Denmark, Odense, Denmark
- 10/01 – 03/06 Technical University Kaiserslautern, Germany
Publications
Selection of publications
- Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites (2023)
- Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics (2023)
- Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes (2023)
- Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites (2021)
- Unexpected Acetylation of Endogenous Aliphatic Amines by ArylamineN-Acetyltransferase NAT2 (2020)
- Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification (2020)
- DNA surface exploration and operator bypassing during target search (2020)
- Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples (2019)
- New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites (2018)
- Chemoselective Probe Containing a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism (2018)
- Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis (2018)
Recent publications
- Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine (2024)
- A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken (2023)
- Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites (2023)
- Sensitive quantification of short-chain fatty acids combined with global metabolomics in microbiome cultures (2023)
- Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics (2023)
All publications
Articles
- Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine (2024)
- A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken (2023)
- Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites (2023)
- Sensitive quantification of short-chain fatty acids combined with global metabolomics in microbiome cultures (2023)
- Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics (2023)
- Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease (2023)
- Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes (2023)
- Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors (2022)
- Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle (2022)
- Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity (2022)
- Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency (2021)
- Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites (2021)
- Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis (2021)
- Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites (2021)
- Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines (2021)
- Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep (2021)
- Unexpected Acetylation of Endogenous Aliphatic Amines by ArylamineN-Acetyltransferase NAT2 (2020)
- Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2. (2020)
- Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host (2020)
- Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples (2020)
- Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification (2020)
- DNA surface exploration and operator bypassing during target search (2020)
- Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World (2020)
- Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples (2019)
- Coupled Enzymatic Treatment and Mass Spectrometric Analysis for Identification of Glucuronidated Metabolites in Human Samples (2019)
- Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry (2019)
- New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites (2018)
- Chemoselective Probe Containing a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism (2018)
- Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control (2018)
- Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis (2018)
- Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG) (2017)
