Michael Williams
Researcher at Department of Surgical Sciences; Functional Pharmacology and neuroscience
- E-mail:
- michael.williams@uu.se
- Visiting address:
- BMC, Husargatan 3
751 24 Uppsala - Postal address:
- Kirurgiska vetenskaper, Box 593
751 24 Uppsala
- Academic merits:
- PhD
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Short presentation
The current aim of my research is to employ the model organism Drosophila melanogaster to evaluate the physiological costs of perturbing genes linked to human obesity. Many of the genes linked with obesity seem to be involved in regulating the development or function of the nervous system. I aim to understand specific functional roles of homologous obesity-linked genes, in the central nervous system, at the organismal, cellular and molecular levels.
Biography
Education
Doctor of Philosophy, Molecular Genetics, University of Notre Dame, Notre
Dame, Indiana, 46556, USA. Received: 1994-1999
Current lab members
Postdoctoral assistants
Dr Lyle Weimerslage (2014-present) Metabolic interactions of environmental toxins in Drosophila.
Dr Maryam Nikpour (2016-present) Control of metabolism and feeding bheaviour in Drosophila.
PhD students
Hao Cao: (2015-present) Project: Metabolic interactions of environmental toxins in Drosophila. Funded by Chinese Research Council.
Research assistant
Giulia Maestri (2015-present)
Publications
Recent publications
- Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes (2024)
- Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors (2023)
- Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis (2023)
- Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster (2023)
- Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy (2022)
All publications
Articles
- Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes (2024)
- Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors (2023)
- Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis (2023)
- Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster (2023)
- Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy (2022)
- The regulatory role of AP-2 beta in monoaminergic neurotransmitter systems (2022)
- The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila (2022)
- Genetics of anorexia nervosa (2022)
- Enhanced Toxicity of Bisphenols Together with UV Filters in Water (2022)
- The potential interaction of environmental pollutants and circadian rhythm regulations that may cause leukemia (2022)
- Role of the synergistic interactions of environmental pollutants in the development of cancer (2022)
- The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms (2022)
- Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia (2021)
- The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion (2021)
- Identification of synergistic and antagonistic actions of environmental pollutants (2021)
- Multidrug Resistance Like Protein 1 Activity in Malpighian Tubules Regulates Lipid Homeostasis in Drosophila (2021)
- Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells (2021)
- Integrating Statistical and Machine-Learning Approach for Meta-Analysis of Bisphenol A-Exposure Datasets Reveals Effects on Mouse Gene Expression within Pathways of Apoptosis and Cell Survival (2021)
- Rodent and fly models in behavioral neuroscience (2021)
- The Drosophila melanogaster Levodopa-Induced Depression Model Exhibits Negative Geotaxis Deficits and Differential Gene Expression in Males and Females (2021)
- Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB1 Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster (2021)
- The Cognitive Effects of Statins are Modified by Age (2020)
- CG4928 is vital for renal function in fruit flies and membrane potential in cells (2020)
- Identification of reference markers for characterizing honey bee (Apis mellifera) hemocyte classes (2020)
- The Synaptic Scaling Literature (2020)
- CCAP regulates feeding behavior via the NPF pathway in Drosophila adults (2020)
- Exposure to the environmental pollutant bisphenol A diglycidyl ether (BADGE) causes cell over-proliferation in Drosophila (2020)
- Evidence that genes involved in hedgehog signaling are associated with both bipolar disorder and high BMI (2019)
- Neural expression patterns and protein modeling of the GABAA receptor ζ subunit in the adult zebrafish (Danio rerio Hamilton, 1822) (2018)
- Neural Cotransmission in Spinal Circuits Governing Locomotion (2018)
- Genes encoding cuticular proteins are components of the Nimrod gene cluster in Drosophila (2017)
- A methylome-wide mQTL analysis reveals associations of methylation sites with GAD1 and HDAC3 SNPs and a general psychiatric risk score (2017)
- Bis-(2-ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster (2016)
- Bis-(2-ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster (2016)
- Genetical Genomics of Behavior (2016)
- The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster (2016)
- The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling (2016)
- Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies (2016)
- Dibutyl Phthalate Exposure Disrupts Evolutionarily Conserved Insulin and Glucagon-Like Signaling in Drosophila Males (2016)
- The Drosophila ETV5 homologue Ets96B (2016)
- Implication of coronin 7 in body weight regulation in humans, mice and flies (2015)
- Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families (2015)
- The obesity-linked Nudt3 Drosophila homolog Aps is associated with insulin signalling (2015)
- The Drosophila Small GTPase Rac2 is Required for Normal Feeding and Mating Behaviour. (2014)
- The GPCR repertoire in the demosponge Amphimedon queenslandica (2014)
- Drosophila Insulin-Producing Cells Are Differentially Modulated by Serotonin and Octopamine Receptors and Affect Social Behavior (2014)
- Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling (2014)
- Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster (2014)
- The Drosophila Kctd-family homologue Kctd12-like modulates male aggression and mating behaviour (2014)
- Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila (2014)
- Exposure to Bisphenol A Affects Lipid Metabolism in Drosophila melanogaster (2014)
- Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA (2013)
- A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response (2012)
- Scientific yellow journalism (2012)
- The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42 (2012)
- Protocol for ex vivo incubation of Drosophila primary post-embryonic haemocytes for real-time analyses (2012)
- Real-time analysis of Drosophila post-embryonic haemocyte behaviour (2012)
- What model organisms and interactomics can reveal about the genetics of human obesity (2012)
- Drosophila cellular immunity (2011)
- The Rho-family GTPase Rac1 regulates integrin localization in Drosophila immunosurveillance cells (2011)
- Dibutyl phthalate exposure disrupts conserved circadian rhythm signaling systems in Drosophila
- Multidrug-Resistance like Protein 1 activity in Malpighian tubules regulates lipid homeostasis in Drosophila
- Developmental bisphenol A diglycidyl ether (BADGE) exposure causes cell over-proliferation in Drosophila
- Pipeline for automated assessment of intra- and inter-individual locomotive behavior in Drosophila melanogaster
- The statin target Hmgcr regulates energy metabolism and food intake through central mechanisms in Drosophila
