Ram Kumar Selvaraju
Researcher at Institutionen för läkemedelskemi; Plattformen för preklinisk PET-MRI
- E-mail:
- ramkumar.selvaraju@ilk.uu.se
- Visiting address:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postal address:
- Dag Hammarskjöldsv 14C, 3 tr
751 83 Uppsala
- CV:
- Download CV
- ORCID:
- 0000-0001-9219-1497
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Short presentation
I am a biotechnologist and my interest incline toward molecular imaging,specializing in use of positron emission tomography (PET) as a tool for preclinical evaluation of novel tracers in drug development.
Keywords
- beta cell imaging
- ct
- diabetes
- molecular imaging
- neuroendocrine cancer
- pet
- preclinical
- spect
Biography
2017- Researcher, Uppsala University (UU), Sweden
2016-2017 Post doctoral researcher, UU, Sweden.
2011-2015 Ph. D. in Pharmacy, UU, Sweden.
Thesis Title: [68Ga]Exendin-4: Bench-to-Bedside.
2009-2011 M. Sc. in Medical Nuclide Techniques, UU, Sweden.
2005-2009 B.Tech in Biotechnology, VIT University, India.
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Research routines are preclinical oriented with use of
* Short lived positron emitting radionuclide such as [11C] ,[18F] & [68Ga]
* Long lived SPECT radionuclides such as [99mTc], [111In] & [177Lu]
* Human islets and cancer cell lines of pancreatic origin.
* Autoradiography
* Small animal models
* In vivo imaging in small animals with PET, SPECT, CT and MR
* Image analysis using software’s such as PMOD, AMIRA, AMIDE and Image J.
Publications
Selection of publications
- Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes (2021)
- Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes. (2019)
- In Vivo Visualization of beta-Cells by Targeting of GPR44 (2018)
- Non-invasive tri-modal visualisation via PET/SPECT/μCT of recombinant human bone morphogenetic protein-2 retention and associated bone regeneration (2018)
- Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4 (2017)
- Positron Emission Tomography to assess the outcome of intraportal islet transplantation (2016)
- Strategy to develop a MAO-A-resistant 5-hydroxy-L-[beta-C-11]tryptophan isotopologue based on deuterium kinetic isotope effects (2014)
- The Positron Emission Tomography ligand [11C]5-Hydroxy-Tryptophan can be used as a surrogate marker for the human endocrine pancreas (2014)
- Quantitative Imaging of Serotonergic Biosynthesis and Degradation in the Endocrine Pancreas (2014)
- Detection of Metastatic Insulinoma by Positron Emission Tomography with [(68)Ga]Exendin-4 - (2014)
- Positron Emission Tomography imaging of the glucagon like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
- Pre-clinical evaluation of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma (2014)
- Dosimetry of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 in rat, non-human primate and human (2014)
- In Vivo Imaging of the Glucagonlike Peptide 1 Receptor in the Pancreas with Ga-68-Labeled DO3A-Exendin-4 (2013)
Recent publications
- Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase (2022)
- Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model (2022)
- Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes (2021)
- 18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand (2021)
- Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass (2019)
All publications
Articles
- Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase (2022)
- Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model (2022)
- Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes (2021)
- 18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand (2021)
- Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass (2019)
- Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes. (2019)
- In Vivo Visualization of beta-Cells by Targeting of GPR44 (2018)
- Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8 (2018)
- Non-invasive tri-modal visualisation via PET/SPECT/μCT of recombinant human bone morphogenetic protein-2 retention and associated bone regeneration (2018)
- The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass. (2018)
- Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate (2018)
- Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4 (2017)
- Novel high affinity affibody for radionuclide imaging of VEGFR2 in glioma vasculature (2017)
- Positron Emission Tomography to assess the outcome of intraportal islet transplantation (2016)
- Quantification of Beta-Cell Mass in Intramuscular Islet Grafts using Radiolabeled Exendin-4 (2016)
- Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma (2016)
- Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26. (2016)
- Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model. (2016)
- Molecular imaging of EGFR and EGFRvIII for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model (2015)
- Improving EGFR imaging by use of an anti-EGFRvIII monoclonal antibody (2015)
- Rat organ distribution of [Lu-177]-DO3A-VS-Cys(40)-Exendin-4 for the estimation of human dosimetry (2015)
- Dosimetry of [Ga-68]Ga-DO3A-VS-Cys(40)-Exendin-4 in rodents, pigs, non-human primates and human (2015)
- Dosimetry of 68Ga and 177Lu labeled Exendin4-impact on feasibility of repeated PET imaging and radiotherapy (2014)
- 5-Hydroxy-L-[beta-C-11]-tryptophan Deuterium Isotopologue Shows Increased Retention In Neuro-endocrine Cells Due To Secondary Kinetic Isotope Effect (2014)
- Strategy to develop a MAO-A-resistant 5-hydroxy-L-[beta-C-11]tryptophan isotopologue based on deuterium kinetic isotope effects (2014)
- The Positron Emission Tomography ligand [11C]5-Hydroxy-Tryptophan can be used as a surrogate marker for the human endocrine pancreas (2014)
- Quantitative Imaging of Serotonergic Biosynthesis and Degradation in the Endocrine Pancreas (2014)
- Detection of Metastatic Insulinoma by Positron Emission Tomography with [(68)Ga]Exendin-4 - (2014)
- Position for Site-Specific Attachment of a DOTA Chelator to Synthetic Affibody Molecules Has a Different Influence on the Targeting Properties of 68Ga- Compared to 111In-Labeled Conjugates. (2014)
- In vivo characterization of a novel engineered CD44v6-targeting bivalent antibody fragment AbD19384 for molecular imaging of squamous cell carcinoma (2014)
- Positron emission tomography imaging of the glucagon-like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
- Imaging of HER3-expressing xenografts in mice using a (99m)Tc(CO) 3-HEHEHE-Z HER3 08699 affibody molecule (2014)
- Incorporation of a Triglutamyl Spacer Improves the Biodistribution of Synthetic Affibody Molecules Radiofluorinated at the N-Terminus via Oxime Formation with (18)F-4-Fluorobenzaldehyde (2014)
- Positron Emission Tomography imaging of the glucagon like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
- PET imaging of the GLP-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
- Pre-clinical evaluation of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma (2014)
- Dosimetry of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 in rat, non-human primate and human (2014)
- Characterization of CD44 variant expression in head and neck squamous cell carcinomas (2014)
- Evaluation of biomarkers for imaging and radio-immunotherapy in combination with HSP90 inhibition in squamous cell carcinomas (2014)
- Histidine-Rich Glycoprotein Uptake and Turnover Is Mediated by Mononuclear Phagocytes. (2014)
- Influence of Nuclides and Chelators on Imaging Using Affibody Molecules (2013)
- 5-Fluoro-[beta-C-11]-L-tryptophan is a functional analogue of 5-hydroxy-[beta-C-11]-L-tryptophan in vitro but not in vivo (2013)
- 5-Fluoro-[beta-C-11]-L-tryptophan is a functional analogue of 5-hydroxy-[beta-C-11]-L-tryptophan in vitro but not in vivo (2013)
- Feasibility of radionuclide imaging of HER3-expressing tumours using technetium-99m labeled affibody molecules (2013)
- In Vivo Imaging of the Glucagonlike Peptide 1 Receptor in the Pancreas with Ga-68-Labeled DO3A-Exendin-4 (2013)
- Influence of macrocyclic chelators on biodistribution and targeting properties of 68Ga-labeled synthetic Affibody molecules. Comparison with 111In-labeled counterparts (2013)
- Influence of Macrocyclic Chelators on the Targeting Properties of 68Ga-Labeled Synthetic Affibody Molecules (2013)
- Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging (2013)
- Ga-68-labelling of Exendin-4, preclinical evaluation of the resultant tracer for the imaging and quantification of insulinomas, and case patient examination (2013)
- Comparative evaluation of anti-HER2 affibody molecules labeled with 68Ga and 111In using maleimido derivatives of DOTA and NODAGA (2012)
- Influence of DOTA chelator position on biodistribution and targeting properties of 111 In-labelled anti-HER2 affibody molecules (2012)
- Development of 124I-labelled anti-PSMA monoclonal antibody capromab for immunoPET staging of prostate cancer (2012)
- Influence of DOTA Chelator Position on Biodistribution and Targeting Properties of In-111-Labeled Synthetic Anti-HER2 Affibody Molecules (2012)
- Pancreatic uptake of [68Ga]DO3A-Exendin4 is mediated by the GLP-1 receptor (2012)
- A novel polymer-based carbonyl scavenger for the detection of ischemic tissues
Books
