Klas Kullander
Professor vid Institutionen för immunologi, genetik och patologi; Forskningsprogram: Genomik och Neurobiologi; Forskargrupp Klas Kullander
- Mobiltelefon:
- 070-846 75 24
- E-post:
- klas.kullander@igp.uu.se
- Besöksadress:
- BMC
Husargatan 3
751 23 UPPSALA - Postadress:
- IGP / BMC
Box 815
751 08 Uppsala
- Akademiska meriter:
- PhD, Docent
- CV:
- Ladda ned CV
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Kort presentation
Klas Kullander ägnar sig åt att förstå neuronala kretsar i hjärnan och ryggmärgen. Han startade enheten för genetisk utvecklingsbiologi år 2004 med målet att skapa en kreativ och interaktiv forskningsmiljö med toppmoderna metoder för att göra bästa möjliga analys av nervsystemets funktioner.
Biografi
PhD i medicinska vetenskaper: Uppsala Universitet 1997-05-22, Avhandlingens titel: Evolutionary and structure-function studies of neurotrophins, Handledare Prof. Ted Ebendal
Postdoc vistelse: EMBL, Heidelberg 1998-01-15 tom 2001-12-30, hos Prof. Rüdiger Klein
Docent: Neurovetenskap, Uppsala Universitet, 2005
Professor: Genetisk utvecklingsbiologi, Uppsala Universitet, 2010
Professor: Medicinsk utvecklings och neurobiologi, Uppsala Universitet, 2014
Forskning
Funktionella neurala nätverk
Neurala nätverk styr varje beteende allt ifrån reflexmässiga rörelser till avancerade kognitiva funktioner. Den funktionella enheten, nervcellen, sammanlänkas till neurala nätverk under utvecklingen och fortsätter formas under hela våra liv.Vår forskning fokuserar på neurala nätverks funktion, att definiera identiteter för specifika nervceller och definiera deras roll i neurala kretsar.
Två faktorer som begränsar avkodningen av neurala kretsars funktion är identifiering av definierade populationer av interneuroner och mätning av reproducerbara beteenden. Således är genetiska verktyg i kombination med in vitro och in vivo mätningar av nätverksaktivitet och beteende av avgörande betydelse. För detta ändamål tillämpar vi nya och avancerade metoder, inklusive virusbaserad spårning, elektrofysiologi, optogenetik och in-vivo avbildning av neural aktivitet. Vi strävar efter högklassig analys av neuronala kretsar, och har tillgång till modern infrastruktur för beteende och virusbaserade metoder för leverans av genetiska verktyg.
Publikationer
Senaste publikationer
- Unraveling the role of Slc10a4 in auditory processing and sensory motor gating (2024)
- A flowchart for adequate controls in virus-based monosynaptic tracing experiments identified Cre-independent leakage of the TVA receptor in RΊGT mice (2024)
- The alpha2 nicotinic acetylcholine receptor, a subunit with unique and selective expression in inhibitory interneurons associated with principal cells (2023)
- Adult spinal Dmrt3 neurons receive direct somatosensory inputs from ipsi- and contralateral primary afferents and from brainstem motor nuclei (2023)
- Cortical somatostatin interneuron subtypes form cell-type-specific circuits (2023)
Alla publikationer
Artiklar
- Unraveling the role of Slc10a4 in auditory processing and sensory motor gating (2024)
- A flowchart for adequate controls in virus-based monosynaptic tracing experiments identified Cre-independent leakage of the TVA receptor in RΊGT mice (2024)
- The alpha2 nicotinic acetylcholine receptor, a subunit with unique and selective expression in inhibitory interneurons associated with principal cells (2023)
- Adult spinal Dmrt3 neurons receive direct somatosensory inputs from ipsi- and contralateral primary afferents and from brainstem motor nuclei (2023)
- Cortical somatostatin interneuron subtypes form cell-type-specific circuits (2023)
- Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26 (2022)
- A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits (2021)
- Single cell transcriptomic analysis of spinal Dmrt3 neurons in zebrafish and mouse identifies distinct subtypes and reveal novel subpopulations within the dI6 domain (2021)
- Cortical disinhibitory circuits (2021)
- Using Cortical Neuron Markers to Target Cells in the Dorsal Cochlear Nucleus (2021)
- Lessons, insights and newly developed tools emerging from behavioral phenotyping core facilities (2020)
- Behavioral Characterization of dmrt3a Mutant Zebrafish Reveals Crucial Aspects of Vertebrate Locomotion through Phenotypes Related to Acceleration (2020)
- EphA4 Is Required for Neural Circuits Controlling Skilled Reaching (2020)
- A prefrontal-paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice (2020)
- EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions (2019)
- The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain. (2019)
- Chrna2-OLM interneurons display different membrane properties and h-current magnitude depending on dorsoventral location (2019)
- Characterization of Dmrt3-Derived Neurons Suggest a Role within Locomotor Circuits (2019)
- The MINDVIEW project (2018)
- Origin and circuitry of spinal locomotor interneurons generating different speeds. (2018)
- Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor (2018)
- Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord (2018)
- OLM alpha 2 Cells Bidirectionally Modulate Learning (2018)
- Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell-motor neuron circuit (2017)
- Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation (2017)
- SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo (2017)
- Differential neuroprotective effects of interleukin-1 receptor antagonist on spinal cord neurons after excitotoxic injury (2017)
- On the photovoltaic effect in localfield potential recordings (2016)
- Multimodal Eph/Ephrin signaling controls several phases of urogenital development (2016)
- Identification of a Neuronal Receptor Controlling Anaphylaxis (2016)
- SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis (2015)
- Novel markers for OLM interneurons in the hippocampus (2015)
- A role for solute carrier family 10 member 4, or vesicular aminergic-associated transporter, in structural remodelling and transmitter release at the mouse neuromuscular junction. (2015)
- Firing properties of Renshaw cells defined by Chrna2 are modulated by hyperpolarizing and small conductance ion currents I-h and I-SK (2015)
- Conditional targeting of medium spiny neurons in the striatal matrix (2015)
- VGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferents (2015)
- Glutamate, Substance P, and Calcitonin Gene-Related Peptide Cooperate in Inflammation-Induced Heat Hyperalgesia (2014)
- Multimodal Use of Calcitonin Gene-Related Peptide and Substance P in Itch and Acute Pain Uncovered by the Elimination of Vesicular Glutamate Transporter 2 from Transient Receptor Potential Cation Channel Subfamily V Member 1 Neurons (2014)
- EphA4-Mediated Ipsilateral Corticospinal Tract Misprojections Are Necessary for Bilateral Voluntary Movements But Not Bilateral Stereotypic Locomotion (2014)
- Genetic analysis of left-right coordination of locomotion (2013)
- Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells (2013)
- Impaired EphA4 signaling leads to congenital hydronephrosis, renal injury, and hypertension (2013)
- Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model (2013)
- The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants (2013)
- Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice (2012)
- Ultrastructural characterization of the mesostriatal dopamine innervation in mice, including two mouse lines of conditional VGLUT2 knockout in dopamine neurons (2012)
- Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons (2012)
- Functional and Histological Outcome after Focal Traumatic Brain Injury Is Not Improved in Conditional EphA4 Knockout Mice (2012)
- OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons (2012)
- DCC mediated axon guidance of spinal interneurons is essential for normal locomotor central pattern generator function (2012)
- VGLUT2-dependent glutamatergic transmission in primary afferents is required for intact nociception in both acute and persistent pain modalities (2012)
- Targeting VGLUT2 in dopamine neurons affects the brain reward system (2012)
- Evaluation of Novel Behavioural Correlates to Electrographic Seizure Activity in Mice (2012)
- Enhanced Sucrose and Cocaine Self-Administration and Cue-Induced Drug Seeking after Loss of VGLUT2 in Midbrain Dopamine Neurons in Mice (2011)
- Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation (2011)
- A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain (2011)
- VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioural activation (2010)
- Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells (2010)
- Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders (2010)
- VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch (2010)
- Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse (2010)
- Reduced VGLUT2 expression increases motor neuron viability in Sod1(G93A) mice (2010)
- Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain (2010)
- Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport (2009)
- ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth (2009)
- Netrin-1-Dependent Spinal Interneuron Subtypes Are Required for the Formation of Left-Right Alternating Locomotor Circuitry (2009)
- Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function (2009)
- Generation and characterization of a Gdf1 conditional null allele (2008)
- Distinct cellular patterns of upregulated chemokine expression supporting a prominent inflammatory role in traumatic brain injury (2008)
- VGLUT2 is essential in neuronal circuitry of cognitive and emotional behavior (2008)
- Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum (2008)
- The evolutionary history and tissue mapping of GPR123 (2007)
- EphA4-Dependent Axon Guidance Is Mediated by the RacGAP α2-Chimaerin (2007)
- Genetic analysis of EphA-dependent signaling mechanisms controlling topographic mapping in vivo (2006)
- Role of glutamate in locomotor rhythm generating neuronal circuitry (2006)
- Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation (2006)
- Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function (2005)
- Genetics moving to neuronal networks (2005)
- Hippocampal plasticity requires postsynaptic ephrinBs. (2004)
- Central pattern generators deciphered by molecular genetics. (2004)
- Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes (2003)
- Role of EphA4 and EphrinB3 in local neuronal circuits that control walking (2003)
- Mechanisms and functions of Eph and ephrin signalling. (2002)
- Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control (2001)
- Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo (2001)
- Lampetra fluviatilis neurotrophin homolog, descendant of a neurotrophin ancestor, discloses the early molecular evolution of neurotrophins in the vertebrate subphylum (1998)
- The Src homology 2 domain protein shb transmits basic fibroblast growth factor - and nerve growth factor - dependent differentiation signals in PC12 cells1 (1998)
- Molecular phylogeny and evolution of the neurotrophins from monotremes and marsupials (1997)
- Two restricted sites on the surface of the NGF molecule independently determine specific TrkA receptor binding and activation (1997)
- Specificity of neurotrophin-3 determined by loss-of-function mutagenesis (1997)
- Design, synthesis, tandem mass spectrometric sequencing and biological activity of NGF mimetics (1996)
- Expression of neurotrophins and trk receptors in the avian retina (1996)
- Neurotrophins and their receptors in chicken neuronal development (1995)
- Developmentally-regulated expression of mRNA for neurotrohin high-affinity (trk) receptors within chich trigeminal sensory neurons (1995)
- Development of spinal motor circuits in the absence of VIAAT-mediated Renshaw cell signaling
- Conditional genetic labeling of the Renshaw cell population for functional studies of motor control
- Inactivation of the Silver gene alters the shape of eumelanosomes but has only a subtle effect on pigmentation
- A new mouse line based on the Gpr101 promoter drives expression of Cre in medium spiny neurons of the striatum.
- Inhibition of hippocampal OLMα2 cells rescue nicotine induced memory impairment
- Hippocampal OLMα2 cells gate basolateral amygdala inputs for threat processing
Böcker
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