Robert Fredriksson

Publikationer

Urval av publikationer

• The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet (2017)
• The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission (2017)
• The gene expression of numerous SLC transporters is altered in the immortalized hypothalamic cell line N25/2 following amino acid starvation (2017)
• A Combinatorial Approach to Induce Sensory Axon Regeneration into the Dorsal Root Avulsed Spinal Cord (2017)
• Putative Membrane-Bound Transporters MFSD14A and MFSD14B Are Neuronal and Affected by Nutrient Availability (2017)
• Characteristics of 29 novel atypical SLCs of MFS type (2017)
• Classification Systems of Secondary Active Transporters (2017)
• The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake (2017)
• Characterization of a unique amino acid transporter, SNAT10, in the Golgi apparatus (2016)
• Amino acid deprivation of neuronal cells changes expression levels of numerous transporters from the SLC family, including several members of the SLC38 family (2016)
• The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis (2016)
• Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney (2016)
• The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling (2016)
• The Drosophila ETV5 homologue Ets96B (2016)
• In Situ Proximity Ligation Assay (PLA) (2015)
• Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS (2015)
• Histological Analysis of SLC38A6 (SNAT6) Expression in Mouse Brain Shows Selective Expression in Excitatory Neurons with High Expression in the Synapses (2014)
• PAT4 is abundantly expressed in excitatory and inhibitory neurons as well as epithelial cells (2014)
• Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster (2014)
• The Drosophila Kctd-family homologue Kctd12-like modulates male aggression and mating behaviour (2014)
• Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila (2014)
• G Protein-Coupled Receptor Deorphanizations (2013)
• Involvement of the Neutral Amino Acid Transporter SLC6A15 and Leucine in Obesity-Related Phenotypes (2013)
• Characterization of the transporterB⁰AT3 (Slc6a17) in the rodent central nervous system (2013)
• B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brain (2013)
• Solute carriers as drug targets (2013)
• Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects (2013)
• The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38 (2008)

Senaste publikationer

• Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes (2024)
• Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors (2023)
• SLC38A10 Deficiency in Mice Affects Plasma Levels of Threonine and Histidine in Males but Not in Females (2023)
• Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro (2023)
• Vesicular glutamate transporter 2 expression in the ventral tegmental area of outbred male rats following exposure to nicotine and alcohol (2023)

Alla publikationer

Artiklar

• Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes (2024)
• Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors (2023)
• SLC38A10 Deficiency in Mice Affects Plasma Levels of Threonine and Histidine in Males but Not in Females (2023)
• Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro (2023)
• Vesicular glutamate transporter 2 expression in the ventral tegmental area of outbred male rats following exposure to nicotine and alcohol (2023)
• Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy (2022)
• A phylogenetic analysis between humans and D. melanogaster (2022)
• SLC38A10 knockout mice display a decreased body weight and an increased risk-taking behavior in the open field test (2022)
• Paracetamol (Acetaminophen) and its Effect on the Developing Mouse Brain (2022)
• SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells (2022)
• The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion (2021)
• Glutamine Uptake via SNAT6 and Caveolin Regulates Glutamine-Glutamate Cycle (2021)
• Molecular genetic analysis of neural stem cells after space flight and simulated microgravity on earth (2021)
• Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns (2021)
• Integrating Statistical and Machine-Learning Approach for Meta-Analysis of Bisphenol A-Exposure Datasets Reveals Effects on Mouse Gene Expression within Pathways of Apoptosis and Cell Survival (2021)
• Evaluation of the dentate gyrus in adult mice exposed to acetaminophen (paracetamol) on postnatal day 10 (2021)
• Toll-like receptor 4 methylation grade is linked to depressive symptom severity (2021)
• SLC38A10 Transporter Plays a Role in Cell Survival Under Oxidative Stress and Glutamate Toxicity (2021)
• Knockdown of SLC38 Transporter Ortholog-CG13743 Reveals a Metabolic Relevance in Drosophila (2020)
• Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption (2020)
• CG4928 is vital for renal function in fruit flies and membrane potential in cells (2020)
• Glucose Availability Alters Gene and Protein Expression of Several Newly Classified and Putative Solute Carriers in Mice Cortex Cell Culture and D. melanogaster (2020)
• Differentiation of Human Embryonic Stem Cells into Neuron, Cholinergic, and Glial Cells (2020)
• The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain. (2019)
• A Single delta(9)-Tetrahydrocannabinol (THC) Dose During Brain Development Affects Markers of Neurotrophy, Oxidative Stress, and Apoptosis (2019)
• SLC38A10 (SNAT10) is Located in ER and Golgi Compartments and Has a Role in Regulating Nascent Protein Synthesis. (2019)
• Nutritional Stress Induced by Amino Acid Starvation Results in Changes for Slc38 Transporters in Immortalized Hypothalamic Neuronal Cells and Primary Cortex Cells (2018)
• A Cannabinoid Receptor Type 1 (CB1R) Agonist Enhances the Developmental Neurotoxicity of Acetaminophen (Paracetamol) (2018)
• The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice (2017)
• The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet (2017)
• The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission (2017)
• The gene expression of numerous SLC transporters is altered in the immortalized hypothalamic cell line N25/2 following amino acid starvation (2017)
• A Combinatorial Approach to Induce Sensory Axon Regeneration into the Dorsal Root Avulsed Spinal Cord (2017)
• Putative Membrane-Bound Transporters MFSD14A and MFSD14B Are Neuronal and Affected by Nutrient Availability (2017)
• Characteristics of 29 novel atypical SLCs of MFS type (2017)
• Classification Systems of Secondary Active Transporters (2017)
• The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake (2017)
• Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice (2017)
• Elevated total plasma-adiponectin is stable over time in young women with bulimia nervosa (2017)
• Vgluts In The Mesocorticolimbic Brain Of Adolescent Outbred Rats Exposed To Alcohol And Nicotine (2017)
• Characterization of a unique amino acid transporter, SNAT10, in the Golgi apparatus (2016)
• mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts (2016)
• Amino acid deprivation of neuronal cells changes expression levels of numerous transporters from the SLC family, including several members of the SLC38 family (2016)
• Oxytocin Acting in the Nucleus Accumbens Core Decreases Food Intake (2016)
• The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis (2016)
• Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney (2016)
• The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling (2016)
• Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies (2016)
• The Drosophila ETV5 homologue Ets96B (2016)
• The Orphan G Protein-Coupled Receptor Gene GPR178 Is Evolutionary Conserved and Altered in Response to Acute Changes in Food Intake (2015)
• GABA and its B-receptor are present at the node of Ranvier in a small population of sensory fibers, implicating a role in myelination (2015)
• Implication of coronin 7 in body weight regulation in humans, mice and flies (2015)
• International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors (2015)
• Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS (2015)
• Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families (2015)
• Roux-En Y Gastric Bypass Surgery Induces Genome-Wide Promoter-Specific Changes in DNA Methylation in Whole Blood of Obese Patients (2015)
• Determination of obesity associated gene variants related to TMEM18 through ultra-deep targeted re-sequencing in a case-control cohort for pediatric obesity. (2015)
• The obesity-linked Nudt3 Drosophila homolog Aps is associated with insulin signalling (2015)
• Methylation Levels of SLC23A2 and NCOR2 Genes Correlate with Spinal Muscular Atrophy Severity (2015)
• Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity (2014)
• Exposure to a high-fat high-sugar diet causes strong up-regulation of proopiomelanocortin and differentially affects dopamine D1 and D2 receptor gene expression in the brainstem of rats (2014)
• Histological Analysis of SLC38A6 (SNAT6) Expression in Mouse Brain Shows Selective Expression in Excitatory Neurons with High Expression in the Synapses (2014)
• BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population (2014)
• The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas (2014)
• Synaptic changes induced by melanocortin signalling (2014)
• Insights into the Origin of Nematode Chemosensory GPCRs (2014)
• The GPCR repertoire in the demosponge Amphimedon queenslandica (2014)
• CDKAL1-Related Single Nucleotide Polymorphisms Are Associated with Insulin Resistance in a Cross-Sectional Cohort of Greek Children (2014)
• PAT4 is abundantly expressed in excitatory and inhibitory neurons as well as epithelial cells (2014)
• Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster (2014)
• The Drosophila Kctd-family homologue Kctd12-like modulates male aggression and mating behaviour (2014)
• Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila (2014)
• Exposure to Bisphenol A Affects Lipid Metabolism in Drosophila melanogaster (2014)
• G Protein-Coupled Receptor Deorphanizations (2013)
• Involvement of the Neutral Amino Acid Transporter SLC6A15 and Leucine in Obesity-Related Phenotypes (2013)
• Characterization of the transporterB⁰AT3 (Slc6a17) in the rodent central nervous system (2013)
• B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brain (2013)
• Remarkable similarities between the hemichordate (Saccoglossus kowalevskii) and vertebrate GPCR repertoire (2013)
• Solute carriers as drug targets (2013)
• The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children (2013)
• Ultra-deep targeted re-sequencing of TMEM18 in two cohorts of European children detects new genetic variants associated with obesity (2013)
• Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects (2013)
• Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children. (2013)
• Early vertebrate origin of melanocortin 2 receptor accessory proteins (MRAPs) (2013)
• Genome-wide analysis shows association of epigenetic changes in regulators of Rab and Rho GTPases with spinal muscular atrophy severity (2013)
• Genome wide analysis reveals association of a FTO gene variant with epigenetic changes (2012)
• Exposure to subliminal arousing stimuli induces robust activation in the amygdala, hippocampus, anterior cingulate, insular cortex and primary visual cortex (2012)
• The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO (2012)
• Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children (2012)
• The Origin of GPCRs (2012)
• Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans (2012)
• Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats (2012)
• The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children (2012)
• Characterization of the neuropeptide Y system in the frog Silurana tropicalis (Pipidae) (2012)
• The Dispanins (2012)
• Polymorphisms in sh2b1 and spns1 loci are associated with triglyceride levels in a healthy population in northern Sweden (2012)
• Identification of Distant Agouti-Like Sequences and Re-Evaluation of the Evolutionary History of the Agouti-Related Peptide (AgRP) (2012)
• What model organisms and interactomics can reveal about the genetics of human obesity (2012)
• The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men (2011)
• Comprehensive analysis of localization of 78 solute carrier genes throughout the subsections of the rat gastrointestinal tract (2011)
• Identification of SLC38A7 (SNAT7) Protein as a Glutamine Transporter Expressed in Neurons (2011)
• The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species (2011)
• Detailed Analysis of Variants in FTO in Association with Body Composition in a Cohort of 70-Year-Olds Suggests a Weakened Effect among Elderly (2011)
• Independent HHsearch, Needleman-Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families (2011)
• Independent HHsearch, Needleman-Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families (2011)
• Fto colocalizes with a satiety mediator oxytocin in the brain and upregulates oxytocin gene expression (2011)
• Fto immunoreactivity is widespread in the rodent brain and abundant in feeding-related sites, but the number of Fto-positive cells is not affected by changes in energy balance (2011)
• Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway (2011)
• GPR162 is expressed in the hypothalamus and is involved in food intake related behaviour (2011)
• Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters (2011)
• The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus (2011)
• Associations between severity of obesity in childhood and adolescence, obesity onset andparental BMI (2011)
• Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae (2011)
• The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children (2010)
• SPRIT (2010)
• C6ORF192 forms a unique evolutionary branch among solute carriers (SLC16, SLC17, and SLC18) and is abundantly expressed in several brain regions (2010)
• Molecular, Immunohistochemical, and Pharmacological Evidence of Oxytocin's Role as Inhibitor of Carbohydrate But Not Fat Intake (2010)
• Glutamate, aspartate and nucleotide transporters in the SLC17 family form four main phylogenetic clusters (2010)
• Mapping the human membrane proteome (2009)
• Inverse association of high-fat diet preference and anxiety-like behavior (2009)
• Sequence polymorphism in a marine bivalve (Perna canaliculus) orphan G protein-coupled receptor gene (2009)
• The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents (2009)
• The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924 (2009)
• Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation (2009)
• The Secretin GPCRs descended from the family of Adhesion GPCRs (2009)
• Critical evaluation of the FANTOM3 non-coding RNA transcripts (2009)
• Hypothalamic FTO is associated with the regulation of energy intake not feeding reward (2009)
• Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding (2009)
• Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function (2009)
• The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain (2008)
• The solute carrier (SLC) complement of the human genome (2008)
• Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat (2008)
• Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. (2008)
• The relative impact of chronic food restriction and acute food deprivation on plasma hormone levels and hypothalamic neuropeptide expression (2008)
• The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors (2008)
• Allelotyping by massively parallel pyrosequencing of SNP-carrying trinucleotide threads (2008)
• The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury (2008)
• The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38 (2008)
• Anxiety-like behaviour predicts the preference for a high-carbohydrate diet in outbred rats (2007)
• The adhesion GPCRs (2007)
• Identification of novel splice variants of Adhesion G protein-coupled receptors (2007)
• Formation of new genes explains lower intron density in mammalian Rhodopsin G protein-coupled receptors (2007)
• The G protein-coupled receptor subset of the rat genome (2007)
• Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes (2007)
• Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family (2007)
• Quantitative Trait Loci for BMD and Bone Strength in an Intercross Between Domestic and Wildtype Chickens (2007)
• Mining the gene repertoire and ESTs for G protein-coupled receptors with evolutionary perspective (2007)
• Neuropeptide Y-family receptors Y₆ and Y₇ in chicken (2006)
• The G protein-coupled receptor subset of the chicken genome (2006)
• Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss (2006)
• Many QTLs with minor additive effects are associated with a large difference in growth between two selection lines in chickens. (2005)
• Feather pecking in chickens is genetically related to behavioural and developmental traits (2005)
• Evaluation of EST-data using the genome assembly (2005)
• Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes (2004)
• The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene. (2004)
• High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3 (2003)
• SLC38A9 is expressed in inhibitory and excitatory neurons and the gene expression changes in mouse brain after starvation and high-fat diet
• Transport of L-glutamine, L-alanine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS.
• Treatment of two human neuroblastoma cell lines with growth factors, ATRA or VIP alters synaptic vesicle glycoprotein 2 (SV2) expression.
• Glucose deprived mouse embryonal cortex cultures respond by altering MFS transporter expression and localization
• Cellular uptake and intra-brain distribution of cyclic cell penetrating peptides: why tissue and cell type matters
• Integrated analysis of transcriptomic and metabolic profiling of SLC38A10 knockout  primary cortex cells
• Vglut2 gene expression in limbic brain areas of outbred rats following exposure to nicotine and ethanol

Kapitel

• In Situ Proximity Ligation Assay (PLA) (2015)
• The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution (2010)

Dataset

• CG4928 knockdown affects the expression of membrane-bound, biosynthesis and  signaling genes (2020)