Finn Hallböök

Kort presentation

Nyckelord

• carcinogenesis
• cell culture
• cell cycle regulation
• cell differentiation
• chicken embryo
• developmental biology
• embryoid body
• embryonal development
• gene expression
• glia cells
• horizontal cells
• müller cells
• neuronal regeneration
• ocular cancer
• organoids
• photoreceptors
• retina
• retinal ganglion cell
• retinal progenitors
• retinoblastom
• stem cells
• transcription factor
• visual system

Publikationer

Senaste publikationer

• MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma (2022)
• High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy (2020)
• Aniridia with PAX6 mutations and narcolepsy (2020)
• Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs (2020)
• Brain Transcriptomics of Wild and Domestic Rabbits Suggests That Changes in Dopamine Signaling and Ciliary Function Contributed to Evolution of Tameness (2020)

Alla publikationer

Artiklar

• MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma (2022)
• High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy (2020)
• Aniridia with PAX6 mutations and narcolepsy (2020)
• Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs (2020)
• Brain Transcriptomics of Wild and Domestic Rabbits Suggests That Changes in Dopamine Signaling and Ciliary Function Contributed to Evolution of Tameness (2020)
• Alpha 2-Adrenergic Receptor Agonist Brimonidine Stimulates ERK1/2 and AKT Signaling via Transactivation of EGF Receptors in the Human MIO-M1 Müller Cell Line (2019)
• An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease (2019)
• Zinc finger gene nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina (2018)
• Changes in brain architecture are consistent with altered fear processing in domestic rabbits (2018)
• Heterogeneity in retinoblastoma (2017)
• The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A (2017)
• Lineage tracing of horizontal and photoreceptor cells in the embryonic chicken retina (2016)
• A regulatory sequence from the retinoid X receptor gamma gene directs expression to horizontal cells and photoreceptors in the embryonic chicken retina (2016)
• Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease (2016)
• Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury (2016)
• Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors (2016)
• Adding another piece to the retinoblastoma puzzle (2015)
• A Genomic Duplication is Associated with Ectopic Eomesodermin Expression in the Embryonic Chicken Comb and Two Duplex-comb Phenotypes (2015)
• The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells (2015)
• Whole Retinal Explants from Chicken Embryos for Electroporation and Chemical Reagent Treatments (2015)
• Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells (2015)
• The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway (2014)
• Transactivation of EGF Receptors in Chicken Muller Cells by α2A-Adrenergic Receptors Stimulated by Brimonidine (2014)
• The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrest (2014)
• Specific spatial distribution of caspase-3 in normal lenses (2014)
• Alternative Splicing of the Chromodomain Protein Morf4l1 Pre-mRNA Has Implications on Cell Differentiation in the Developing Chicken Retina (2013)
• Forkheadbox N4 (FoxN4) triggers context-dependent differentiation in the developing chick retina and neural tube (2013)
• Heterogenic Final Cell Cycle by Chicken Retinal Lim1 Horizontal Progenitor Cells Leads to Heteroploid Cells with a Remaining Replicated Genome (2013)
• The expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight (2013)
• Evolution of TUNEL-labeling in the Rat Lens After In Vivo Exposure to Just Above Threshold Dose UVB (2013)
• Sonic Hedgehog-Signalling Patterns the Developing Chicken Comb as Revealed by Exploration of the Pea-comb Mutation (2012)
• Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation (2012)
• The Rose-comb Mutation in Chickens Constitutes a Structural Rearrangement Causing Both Altered Comb Morphology and Defective Sperm Motility (2012)
• GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium (2012)
• A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken (2011)
• Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation (2011)
• Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight (2011)
• Pax2 Is Expressed in a Subpopulation of Muller Cells in the Central Chick Retina (2010)
• Multiple receptor tyrosine kinases are expressed in adult rat retinal ganglion cells as revealed by single-cell degenerate primer polymerase chain reaction (2010)
• Increased A-to-I RNA editing of the transcript for GABA_A receptor subunit α3 during chick retinal development (2010)
• Whole genome resequencing reveals loci under selection during chicken domestication (2010)
• Immediate Upregulation of Proteins Belonging to Different Branches of the Apoptotic Cascade in the Retina after Optic Nerve Transection and Optic Nerve Crush (2009)
• Horizontal cell progenitors arrest in G2-phase and undergo terminal mitosis on the vitreal side of the chick retina (2009)
• Proviral integrations and expression of endogenous Avian leucosis virus during long term selection for high and low body weight in two chicken lines (2009)
• Extremely different behaviours in high and low body weight lines of chicken are associated with differential expression of genes involved in neuronal plasticity (2009)
• The Dominant white mutation in the PMEL17 gene does not cause visual impairment in chickens (2009)
• Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens (2009)
• Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush (2008)
• Temporal and spatial expression of transcription factors FoxN4, Ptf1a, Prox1, Isl1 and Lim1 mRNA in the developing chick retina (2008)
• Axon-bearing and axon-less horizontal cell subtypes are generated consecutively during chick retinal development from progenitors that are sensitive to follistatin (2008)
• The amphioxus genome illuminates vertebrate origins and cephalochordate biology (2008)
• Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons (2007)
• Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development (2007)
• A genomic view of the sea urchin nervous system (2006)
• Early identification of retinal subtypes in the developing, pre-laminated chick retina using the transcription factors Prox1, Lim1, Ap2α, Pax6, Isl1, Isl2, Lim3 and Chx10 (2006)
• Formation and evolution of the chordate neurotrophin and Trk receptor genes. (2006)
• Formation and evolution of the chordate neurotrophin and Trk receptor genes (2006)
• Three insulin-relaxin-like genes in Ciona intestinalis (2006)
• Conserved Synteny Between the Ciona Genome and Human Paralogons Identifies Large Duplication Events in the Molecular Evolution of the Insulin-Relaxin Gene Family (2006)
• The genome of the sea urchin Strongylocentrotus purpuratus (2006)
• Expression analysis of growth and energy regulation-associated genes in two divergent chicken strains. (2005)
• Genome duplication-driven evolution of gene families: insights from the formation of the insulin family (2005)
• Newborn horizontal cells migrate bi-directionally across the neuroepithelium during retinal development (2004)
• GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection (2004)
• Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection (2003)
• Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates (2003)
• Generation of retinal ganglion cells is modulated by caspase-dependent programmed cell death (2003)
• Rat retinal ganglion cells upregulate the pro-apoptotic BH3-only protein Bim after optic nerve transection (2003)
• An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport (2003)
• An Improved Cell Culture Model Based on 2/4/A1 Cell Monolayers for Studies of Intestinal Drug Transport (2003)
• Overlapping and specific patterns of GDNF, c-ret and GFR mRNA expression in the developing chicken retina (2002)
• The human hox-bearing chromosome regions did arise by block or chromosome (or even genome) duplications (2002)
• Biotin decreases retinal apoptosis and induces eye malformations in the early chick embryo (2002)
• Nerve growth factor is expressed by postmitotic avian retinal horizontal cells and supports their survival during development in an autocrine mode of action (2001)
• Analysis of subcellular location of bestrophin in transfected RPE cell lines (2000)
• Gene functional analysis in nervous system (2000)
• Evolution of the vertebrate neurotrophin and Trk receptor gene families (1999)
• Evolution of the vertebrate neurotrophin and Trk receptor gene families (1999)
• Lampetra fluviatilis neurotrophin homolog, descendant of a neurotrophin ancestor, discloses the early molecular evolution of neurotrophins in the vertebrate subphylum (1998)
• Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development (1998)
• Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development (1998)
• Kainic acid, tetrodotoxin and light modulate expression of brain-derived neurotrophic factor in developing avian retinal ganglion cells and their tectal target (1998)
• MAP kinase phosphatase-1 mRNA is expressed in embryonic sympathetic neurons and is upregulated after NGF stimulation (1998)
• Distribution of BDNF and trkB mRNA in the otic region of 3.5 and 4.5 day chick embryos as revealed with a combination of in situ hybridization and tract tracing (1997)
• Characterization and evaluation of antisense oligonucleotides (1997)
• Molecular phylogeny and evolution of the neurotrophins from monotremes and marsupials (1997)
• Human mast cells express functional TrkA and are a source of nerve growth factor (1997)
• Expression of neurotrophins and Trk receptors in the developing, adult, and regenerating avian cochlea (1997)
• A simple and reliable technique to combine oligonucleotide probe in situ hybridization with neuronal tract tracing in vertebrate embryos. (1996)
• Expression of neurotrophins and trk receptors in the avian retina (1996)
• Neurotrophins and their receptors in chicken neuronal development (1995)
• Developmentally-regulated expression of mRNA for neurotrohin high-affinity (trk) receptors within chich trigeminal sensory neurons (1995)
• Differential actions of neurotrophins in the locus coeruleus and basal forebrain. (1993)
• Expression of neurotrophin-4 mRNA during oogenesis in Xenopus laevis. (1992)
• Human nerve growth factor (1991)
• Distinct functions for thyroid hormone receptors alpha and beta in brain development indicated by differential expression of receptor genes. (1991)
• Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. (1991)
• Expression of nerve growth factor receptor mRNA during early development of the chicken embryo (1990)
• Structure-function studies of nerve growth factor (1990)
• Recombinant human beta-nerve growth factor (NGF) (1990)
• Development and regional expression of chicken neuroleukin (glucose-6-phosphate isomerase) messenger RNA. (1989)
• Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat. (1988)
• Production and characterization of biologically active recombinant beta nerve growth factor (1988)

Böcker

• Evolution of the neurotrophins and their receptors (1999)