Lene Uhrbom
- Telefon:
- 018-471 50 63
- Mobiltelefon:
- 070-167 98 67
- E-post:
- lene.uhrbom@igp.uu.se
- Besöksadress:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postadress:
- Rudbecklaboratoriet
751 85 UPPSALA
- Akademiska meriter:
- DMSc, docent 2004
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Kort presentation
Professor i Molekylär hjärntumörforskning
Nyckelord
- astrocyte
- brain
- cancer
- cell biology
- central nervous system
- glioblastoma
- glioma
- molecular biology
- neural stem cell
- neuro-oncology
- oligodendrocyte
- patient-derived models
Biografi
2023, Professor i Molekylär hjärntumörforskning, Uppsala Universitet
2015, Universitetslektor i Molekylär hjärntumörforskning, Uppsala Universitet
2005, Docent i Tumörbiologi, Uppsala Universitet
2003, Forskarassistent i Molekylärgenetisk cancerforskning, Uppsala Universitet
2001 - 2003, Postdoktor, Memorial Sloan-Kettering Cancer Center, New York
1999 - 2000, Postdoktor, Uppsala Universitet
1999, Med Dr i patologi, Uppsala Universitet
Publikationer
Urval av publikationer
- Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival (2022)
- A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures (2020)
- LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients (2019)
- Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin (2017)
- Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype (2017)
- The Human Glioblastoma Cell Culture Resource (2015)
- Oncogenic Signaling Is Dominant to Cell of Origin and Dictates Astrocytic or Oligodendroglial Tumor Development from Oligodendrocyte Precursor Cells (2014)
- Oligodendroglioma models (2013)
- On the origin of glioma (2012)
- RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability (2011)
- Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma (2009)
- Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence (2009)
- Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma (2007)
- Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis. (2005)
- Somatic cell gene transfer (2004)
- Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. (2004)
- Dissecting gliomagemesis using glial-specifictransgenic mouse models (2003)
- Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model. (2003)
- Ink4a-Arf loss cooperates with KRas activation in astrocytes and neuralprogenitors to generate glioblastomas of various morphologies depending onactivated Akt. (2002)
- Glial tumors of the CNS (2001)
- Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors. (2001)
- Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells (2000)
- Induction of brain tumors in mice using a recombinant PDGF B retrovirus (1998)
- Induction of senescence in human malignant glioma cells by p16INK4A (1997)
Senaste publikationer
- Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures (2023)
- Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative (2023)
- Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma (2023)
- Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas (2023)
- Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma (2023)
Alla publikationer
Artiklar
- Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures (2023)
- Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative (2023)
- Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma (2023)
- Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas (2023)
- Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma (2023)
- Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival (2022)
- Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing (2021)
- FACT-seq (2021)
- A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma (2020)
- A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures (2020)
- BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells (2019)
- Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors (2019)
- LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients (2019)
- Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells (2018)
- Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity (2018)
- Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin (2017)
- Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses (2017)
- Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential (2017)
- Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype (2017)
- Case-specific potentiation of glioblastoma drugs by pterostilbene (2016)
- Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition (2016)
- ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells (2016)
- Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells (2016)
- Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma (2015)
- Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells (2015)
- The Human Glioblastoma Cell Culture Resource (2015)
- GABA-A receptor currents in a cell line (U3047MG) derived from a human glioblastoma tumor are enhanced by etomidate, propofol and diazepam (2014)
- Oncogenic Signaling Is Dominant to Cell of Origin and Dictates Astrocytic or Oligodendroglial Tumor Development from Oligodendrocyte Precursor Cells (2014)
- Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells (2014)
- Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions (2013)
- Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures (2013)
- On the origin of glioma (2012)
- miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma (2012)
- Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells (2011)
- PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation (2011)
- Mast Cell Accumulation in Glioblastoma with a Potential Role for Stem Cell Factor and Chemokine CXCL12 (2011)
- CGGBP1 regulates cell cycle in cancer cells (2011)
- RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability (2011)
- Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma (2009)
- Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma (2009)
- IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas (2009)
- Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence (2009)
- Sox10 Has a Broad Expression Pattern in Gliomas and Enhances Platelet-Derived Growth Factor-B–Induced Gliomagenesis (2007)
- Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma (2007)
- Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis. (2005)
- Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging (2004)
- Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. (2004)
- Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model. (2003)
- p190RhoGAP can act to inhibit PDGF-induced gliomas in mice (2003)
- Ink4a-Arf loss cooperates with KRas activation in astrocytes and neuralprogenitors to generate glioblastomas of various morphologies depending onactivated Akt. (2002)
- Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors. (2001)
- Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells (2000)
- Induction of brain tumors in mice using a recombinant PDGF B retrovirus (1998)
- Induction of senescence in human malignant glioma cells by p16INK4A (1997)
- Targeting SOX2 in glioblastoma cells reveals heterogeneity in SOX2 dependency
- Paired glioblastoma cell cultures of the fluorescent bulk tumor and non-fluorescent tumor margin display differential phenotypes and cell states across patients
Kapitel
