Mikael Hedeland
Professor vid Institutionen för läkemedelskemi; Analytisk farmaceutisk kemi
- Telefon:
- 018-471 43 40
- Mobiltelefon:
- 070-657 16 63
- E-post:
- mikael.hedeland@ilk.uu.se
- Besöksadress:
- Uppsala biomedicinska centrum BMC, Husarg. 3
- Postadress:
- Box 574
751 23 UPPSALA
- Akademiska meriter:
- Docent, FarmD
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Nyckelord
- bioanalysis
- chromatography
- doping control
- drug metabolism
- mass spectrometry
Biografi
Master in Pharmaceutical Science
Ph.D. in Analytical Pharmaceutical Chemistry 1999
Docent (associate professor) 2007
Gästprofessor (visiting professor) 2013
Adjungerad professor (adjunct professor) 2015
Professor (full professor) 2018
Forskning
Bioanalysis of drugs and their metabolites with chromatography coupled to mass spectrometry.
Multidisciplinary projects in collaboration with researchers in biopharmaceutics, pharmacokinetics, pharmacology, cardiology, veterinary medicine etc.
Metabolism of drugs and other substances of abuse in connection with doping control.
Mass spectrometry-based methods for detection of acitve botulinum neurotoxin in biological material.
Publikationer
Senaste publikationer
- Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells (2024)
- Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth (2023)
- Trials and tribulations of statistical significance in biochemistry and omics (2023)
- Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control (2023)
- A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites (2023)
Alla publikationer
Artiklar
- Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells (2024)
- Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth (2023)
- Trials and tribulations of statistical significance in biochemistry and omics (2023)
- Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control (2023)
- A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites (2023)
- Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials (2023)
- Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding (2022)
- Plasma atropine concentrations associated with decreased intestinal motility in horses (2022)
- Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767) (2022)
- Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis (2022)
- Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study (2022)
- Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species (2022)
- Neomycin removal using the white rot fungus Trametes versicolor (2022)
- Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia (2021)
- Etherglycerophospholipids and ferroptosis (2021)
- Anthracyclins Increase PUFAs (2021)
- Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats (2021)
- Prednisolone in Dogs (2021)
- Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples (2021)
- The effects of sampling and storage conditions on the metabolite profile of the marine sponge Geodia barretti (2021)
- In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes (2021)
- Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control (2021)
- Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples (2021)
- Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media (2021)
- Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility (2021)
- Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks (2021)
- Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits (2020)
- Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver (2020)
- Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat (2020)
- The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin (2020)
- Removal of nonylphenol polyethoxylates by adsorption on polyurethane foam and biodegradation using immobilized Trametes versicolor (2020)
- Common Fatty Markers in Diseases with Dysregulated Lipogenesis (2019)
- Disposition and effect of intra-articularly administered dexamethasone on lipopolysaccharide induced equine synovitis (2019)
- Adduct formation in electrospray ionisation-mass spectrometry with hydrophilic interaction liquid chromatography is strongly affected by the inorganic ion concentration of the samples (2019)
- Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling (2019)
- An LCMS-based untargeted metabolomics protocol for cochlear perilymph (2019)
- Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions (2019)
- Removal of toluene diamine and its derivatives frompolyurethane foam using immobilized Trametes versicolor (2019)
- Removal of diclofenac from a non-sterile aqueous system using Trametes versicolor with an emphasis on adsorption and biodegradation mechanisms (2019)
- Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with and without preeclampsia (2018)
- Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'" (2018)
- Cetirizine per os (2018)
- Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control (2018)
- Major signal suppression from metal ion clusters in SFC/ESI-MS (2018)
- Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites. (2018)
- Effects of Oral Supplementation With Nitrate-Rich Beetroot Juice in Patients With Pulmonary Arterial Hypertension-Results From BEET-PAH, an Exploratory Randomized, Double-Blind, Placebo-Controlled, Crossover Study. (2018)
- Alterations in plasma L-arginine and methylarginines in heart failure and after heart transplantation (2018)
- Jejunal absorption of aprepitant from nanosuspensions (2018)
- Plasma l-arginine levels distinguish pulmonary arterial hypertension from left ventricular systolic dysfunction (2018)
- The differences in matrix effect between supercritical fluid chromatography and reversed phase liquid chromatography coupled to ESI/MS (2018)
- Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel (2017)
- Investigation of the metabolites of the HIF stabilizer FG-4592 (roxadustat) in five different in vitro models and in a human doping control sample using high resolution mass spectrometry (2017)
- Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses (2017)
- In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma (2017)
- Quantification of dimethylsulfoxide (DMSO) in equine plasma and urine using HILIC-MS/MS (2017)
- A quantitative approach to analysing cortisol response in the horse (2016)
- Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry (2016)
- Identification of Leachables from Trametes versicolor in Biodegradation Experiments (2016)
- Identification of transformation products from -blocking agents formed in wetland microcosms using LC-Q-ToF (2016)
- Nickel in equine sports drug testing - pilot study results on urinary nickel concentrations (2016)
- Fully automated determination of nicotine and its major metabolites in whole blood by means of a DBS online-SPE LC-HR-MS/MS approach for sports drug testing (2016)
- Plasma concentration-dependent suppression of endogenous hydrocortisone in the horse after intramuscular administration of dexamethasone-21-isonicotinate (2015)
- Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes (2015)
- Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension (2015)
- A novel trapping system for the detection of reactive drug metabolites using the fungus Cunninghamella elegans and high resolution mass spectrometry (2015)
- Seafood sold in Sweden contains BMAA (2015)
- Acute vasodilator response to vardenafil and clinical outcome in patients with pulmonary hypertension (2015)
- Rapid chiral separation of atenolol, metoprolol, propranolol and the zwitterionic metoprolol acid using supercritical fluid chromatography-tandem mass spectrometry - Application to wetland microcosms (2015)
- Characterization of a non-approved selective androgen receptor modulator drug candidate sold via the Internet and identification of in vitro generated phase-I metabolites for human sports drug testing (2015)
- Validation of the Endopep-MS method for qualitative detection of active botulinum neurotoxins in human and chicken serum (2014)
- The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs (2014)
- Investigation of Hepatobiliary Disposition of Doxorubicin Following Intrahepatic Delivery of Different Dosage Forms (2014)
- High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile (2014)
- Isolation and characterization of a beta-glucuronide of hydroxylated SARM S1 produced using a combination of biotransformation and chemical oxidation (2014)
- Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs (2014)
- Synthesis, characterization, and detection of new oxandrolone metabolites as long-term markers in sports drug testing (2013)
- Mass spectrometric characterization of glucuronides formed by a new concept, combining Cunninghamella elegans with TEMPO (2013)
- The fungus Cunninghamella elegans can produce human and equine metabolites of selective androgen receptor modulators (SARMs) (2013)
- High inter-individual variability of vardenafil pharmacokinetics in patients with pulmonary hypertension (2013)
- Mass Spectrometric Detection of Protein-Based Toxins (2013)
- Acute haemodynamic response in relation to plasma vardenafil concentrations in patients with pulmonary hypertension (2012)
- Characterization of In Vitro Synthesized Equine Metabolites of the Selective Androgen Receptor Modulators S24 and S4 (2012)
- Structural elucidation of phase I and II metabolites of bupivacaine in horse urine and fungi of the Cunninghamella species using liquid chromatography/multi-stage mass spectrometry (2012)
- Confirmation of botulism in birds and cattle by the mouse bioassay and Endopep-MS (2011)
- In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5 alpha-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole (2011)
- The Effect of Acute Administration of Rifampicin and Imatinib on the Enterohepatic Transport of Rosuvastatin In Vivo (2010)
- Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers (2010)
- Structural elucidation of N-oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification (2010)
- The Enterohepatic Disposition of Rosuvastatin in Pigs and The Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil (2009)
- In vitro formation of phase I and II metabolites of propranolol and determination of their structures using chemical derivatization and liquid chromatography tandem mass spectrometry (2009)
- The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men (2009)
- Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry (2009)
- A mass spectromeric study on meloxicam metabolism in horses and the fungus Cunninghamella elegans, and the relevance of this microbial system as a model of drug metabolism in the horse (2009)
- Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver (2009)
- Structural evaluation of the glucuronides of morphine and formoterol using chemical derivatization with 1,2-dimethylimidazole-4-sulfonyl chloride and liquid chromatography/ion trap mass spectrometry (2008)
- Biliary secretion of rosuvastatin and bile acids in humans during the absorption phase. (2006)
- Detection of altrenogest and its metabolites in post administration horse urine using liquid chromatography tandem mass spectrometry-increased sensitivity by chemical derivatisation of the glucuronic acid conjugate. (2006)
- Differentiation of estriol glucuronide isomers by chemical derivatization and electrospray tandem mass spectrometry (2006)
- Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers. (2006)
- First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model. (2006)
- Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry. (2006)
- Clinical pharmacology of clemastine in healthy dogs. (2004)
- Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry (2004)
- St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism (2004)
- Identification of some new clemastine metabolites in dog, horse, and human urine with liquid chromatography/tandem mass spectrometry. (2004)
- Chiral separation of amines with N-benzoxycarbonylglycyl-L-proline as selector in non-aqueous capillary electrophoresis using methanol and 1,2-dichloroethane in the background electrolyte (2003)
- Development of a chiral non-aqueous capillary electrophoretic system using the partial filling technique with UV and mass spectrometric detection (2003)
- Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine. (2003)
- Non-aqueous capillary electrophoretic separation of enantiomeric amineswith (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid as chiralcounter ion. (2001)
- Non-aquoeus capillary electrophoretic separation of enantiomeric amines with (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid as chiral counter ion (2001)
- Optimization of In Vitro Microsome Incubations for Improved Drug Metabolite Yield Utilizing Experimental Design
- LCMS-based untargeted metabolomics of guinea pig perilymph using a novel separation method for sequential analysis of hydrophilic and lipophilic compounds: Studying the effect of hydrogen gas on noise-induced hearing loss
- Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions
Konferenser
- Developing reactive oxygen species-sensitive cellulose nanofibers for chronic wound care (2022)
- The differences in matrix effects between supercritical fluid chromatography and reversed phase liquid chromatography coupled to ESI/MS analyzing blood plasma (2017)
- Matrix effects: Do they differ between SFC/ESI-MS and LC/ESI-MS (2016)
- Antihistamine effect of cetirizine after oral administrator in the dog (2015)
- A quantitative approach to analysing hydrocortisone response in the horse (2015)
- Quantification of SARMs S1, S4 and S22 and detection of their metabolites in equine plasma using UHPLC-Q-TOF (2015)
- Quantification of SARMs S1, S4 and S22 and detection of their metabolites in equine plasma usning UHPLC-Q-TOF (2015)
- Characterization of a Selective Androgen Receptor Modulator Drug Candidate and Identification of In Vitro Generated Metabolites for Sports Drug Testing (2015)
- Charactierization of a selective androgen receptor modulator drug candidate and identification of in vitro generated metabolites for sports drug testing (2015)
- Validation of the endopep-MS method for qualitative detection of active botulinum neurotoxins in human or chicken serum (2014)
- Additional evidence for dexamethasone screening limits (2014)
- In vivo metabolism of Selective Androgen Receptor Modulators (SARMs) in the horse (2014)
- In vivo metabolism of selective androgen receptor modulators (SARMs) in the horse (2014)
- Chiral separation of three beta-blocking pharmaceuticals and a major metabolite using SFC-MS (2014)
- Turning drug glucosides into glucuronides - making fungal incubations work together with chemical derivatization (2013)
- Drug glucuronides synthesized using a new concept combining Cunninghamella elegans with TEMPO (2013)
- Evaluation of the fungus Cunninghamella elegans as a model for the formation of reactive metabolites using glutathione trapping and UHPLCC/HRMS (2013)
- Chiral separation of three β-blocking pharmaceuticals and a majormetabolite using SFC-MS (2013)
- Mass spectrometric study of the metabolism of Selective Androgen Receptor Modulators (SARMs) in the fungus Cunninghamella elegans (2012)
- Mass spectrometric study of the metabolism of Selective Androgen Receptor Modulators (SARMs) in the fungus Cunninghamella elegans (2012)
- Mass spectrometric study of the metabolism of Selective Androgen Receptor Modulators (SARMs) in the fungus Cunninghamella elegans (2012)
- Local and sustained release in the treatment of primary liver cancer? Pharmacokinetic understanding of two formulations for intra arterial injection (2012)
- Improved Pharmacokinetic Understanding of Two Formulations for Intra-arterial Injection (2012)
- Improved Pharmacokinetic Understanding of Two Formulations for Intra-arterial Injection (2012)
- A mass spectrometric study of bupivacaine metabolites found in fungi and horse (2012)
- A mass spectrometric study of bupivacaine metabolites found in fungi and horse (2012)
- Comparison of vardenafil and adenosine for vasoreactivity testing in patients with pulmonary hypertension (2012)
- Verapamil Affects the Pharmacokinetics and the Hepatic Disposition of Fexofenadine in Pigs (2012)
- The relevance of using a fungus as a model of equine metabolism (2010)
- The effect of gemfibrozil on the biliary excretion of rosuvastatin in pig and man (2009)
- The hepatobiliary disposition of rosuvastatin in pigs and the impact of concomitant dosing with cyclosporine. (2009)
- Preparation of Drug Metabolites (2009)
- Metabolitidentifiering av finasterid i human galla och urin (2009)
- Identification of hydroxylated and glucuronidated metabolites of finasteride in human bile and urine (2009)
- Metabolite identification by mass spectrometry of the 5α-reductase inhibitor finasteride in vitro and in vivo (2009)
- Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver (2009)
- The biliary excretion of rosuvastatin and gemfibrozil in healthy humans (2008)
- The biliary excretion of rosuvastatin and gemfibrozil in healthy humans (2008)
- Intestinal and liver CYP3A4-mediated metabolism of R/S-verapamil in pigs (2008)
- The effect of St John’s wort on the pharmacokinetics and metabolism of finasteride in man (2008)
- The effect of St. John’s wort treatment on finasteride pharmacokinetics and identification of new phase I and phase II metabolites in humans (2008)
- The effect of St John’s Wort treatment on finasteride metabolism and identification of new finasteride metabolites in humans (2008)
- The effect of St John's Wort on the pharmacokinetics and metabolism of finasteride in healthy men (2008)
- Structural evaluation of glucuronides of morphine and formoterol using chemical derivatization with 1,2-dimethylimidazole-4-sulfonyl chloride and LC-MSn (2008)
- Characterization of C- and N-oxidized Clemastine Metabolites using LC-MSn (2008)
