Dan Larhammar
Professor i molekylär cellbiologi vid Institutionen för medicinsk cellbiologi; Forskargrupp Dan Larhammar
- Telefon:
- 018-471 41 73
- Fax:
- 018-51 15 40
- E-post:
- dan.larhammar@uu.se
- Besöksadress:
- BMC
Husargatan 3
751 23 Uppsala - Postadress:
- Box 571
751 23 UPPSALA
- Akademiska meriter:
- PhD, Docent
- CV:
- Ladda ned CV
Mer information visas för dig som medarbetare om du loggar in.
Kort presentation
Dan Larhammar, professor i molekylär cellbiologi sedan 1994. Erhöll apotekarexamen 1980, disputerade vid medicinska fakulteten 1984. Ledamot av Kungliga Vetenskapsakademien sedan 2007, Akademiens preses sedan 2018. Forskar inom områdena evolution, neurobiologi, endokrinologi och farmakologi. Har stort intresse för distinktionen mellan vetenskap och pseudovetenskap. Har handlett 22 doktorander till disputation. Forskningsgruppen har för närvarande tre medlemmar.
Publikationer
Senaste publikationer
- The Concise Guide to PHARMACOLOGY 2023/24 (2023)
- Identification of a new Kir6 potassium channel and comparison of properties of Kir6 subtypes by structural modelling and molecular dynamics (2023)
- Ancient multiplicity in cyclic nucleotide-gated (CNG) cation channel repertoire was reduced in the ancestor of Olfactores before reexpansion by whole genome duplications in vertebrates (2022)
- A D-peptide ligand of neuropeptide Y receptor Y-1 serves as nanocarrier traversing of the blood brain barrier and targets glioma (2022)
- Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses (2022)
Alla publikationer
Artiklar
- The Concise Guide to PHARMACOLOGY 2023/24 (2023)
- Identification of a new Kir6 potassium channel and comparison of properties of Kir6 subtypes by structural modelling and molecular dynamics (2023)
- Ancient multiplicity in cyclic nucleotide-gated (CNG) cation channel repertoire was reduced in the ancestor of Olfactores before reexpansion by whole genome duplications in vertebrates (2022)
- A D-peptide ligand of neuropeptide Y receptor Y-1 serves as nanocarrier traversing of the blood brain barrier and targets glioma (2022)
- Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses (2022)
- The Evolution of Oxytocin and Vasotocin Receptor Genes in Jawed Vertebrates (2022)
- Protein kinase C family evolution in jawed vertebrates (2021)
- Circadian regulation of phosphodiesterase 6 genes in zebrafish differs between cones and rods (2020)
- Corticotropin-Releasing Hormone (CRH) Gene Family Duplications in Lampreys Correlate With Two Early Vertebrate Genome Doublings (2020)
- Globalization of Traditional Chinese Medicine (2020)
- Oxytocin Receptors Regulate Social Preference in Zebrafish (2020)
- The Neuropeptide Y Y-2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y-2 Activation Reduces Histaminergic and IL-31-Induced Itch (2020)
- Evolution of vertebrate nicotinic acetylcholine receptors (2019)
- Copy number determination of the gene for the human pancreatic polypeptide receptor NPY4R using read depth analysis and droplet digital PCR. (2019)
- Functional characterization in vitro of twelve naturally occurring variants of the human pancreatic polypeptide receptor NPY4R (2019)
- Evolution of neuropeptide signalling systems (2018)
- The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch (2018)
- Evolution of the receptors for growth hormone, prolactin, erythropoietin and thrombopoietin in relation to the vertebrate tetraploidizations (2018)
- Evolution of the growth hormone, prolactin, prolactin 2 and somatolactin family (2018)
- Evolution of the muscarinic acetylcholine receptors in vertebrates (2018)
- Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference (2018)
- Elucidation of the Binding Mode of the Carboxyterminal Region of Peptide YY to the Human Y-2 Receptor (2018)
- Structural basis of ligand binding modes at the neuropeptide Y Y-1 receptor (2018)
- Assessing and regulating homeopathic products (2017)
- The Arg-Phe-amide peptide 26RFa/glutamine RF-amide peptide and its receptor (2017)
- Corticotropin-releasing hormone family evolution (2016)
- Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity (2016)
- Transducin Duplicates in the Zebrafish Retina and Pineal Complex (2015)
- Characterization of peptide QRFP (26RFa) and its receptor from amphioxus, Branchiostoma floridae (2015)
- Neuropeptide Y family receptors Y1 and Y2 from sea lamprey, Petromyzon marinus: cloning and pharmacological characterization (2015)
- Comparative evolution of peptide hormone-binding GPCRs (2014)
- New insights into the evolution of vertebrate CRH (corticotropin-releasing hormone) and invertebrate DH44 (diuretic hormone 44) receptors in metazoans (2014)
- Turtle ghrelin (2014)
- Unexpected multiplicity of QRFP receptors in early vertebrate evolution (2014)
- Neuropeptide Y, social function and long-term outcome in schizophrenia (2014)
- Molecular evolution of GPCRS: (2014)
- The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications (2013)
- Ancient Grandeur of the Vertebrate Neuropeptide Y System Shown by the Coelacanth Latimeria chalumnae (2013)
- Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b (2013)
- Mutagenesis and Computational Modeling of Human G‑Protein-Coupled Receptor Y2 for Neuropeptide Y and Peptide YY (2013)
- Cloning and pharmacological characterization of the neuropeptide Y receptor Y5 in the sea lamprey, Petromyzon marinus (2013)
- Detecting ligand interactions with G protein-coupled receptors in real-time on living cells (2013)
- Evolution of the Vertebrate Paralemmin Gene Family (2012)
- Expansion of transducin subunit gene families in early vertebrate tetraploidizations (2012)
- Tacka dna-explosionen för att du finns (2012)
- The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, inclucing two distinct V2 subtypes (2012)
- The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements. (2012)
- Characterization of the neuropeptide Y system in the frog Silurana tropicalis (Pipidae) (2012)
- Test for personality characteristics in dogs used in research (2012)
- Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties (2011)
- Identification of positions in the human neuropeptide Y/peptide YY receptor Y2 that contribute to pharmacological differences between receptor subtypes (2011)
- Regulation of Synaptic Vesicle Budding and Dynamin Function by an EHD ATPase (2011)
- Internalization studies of chimeric neuropeptide Y receptors Y1 and Y2 suggest complex interactions between cytoplasmic domains (2011)
- Evolution of the insulin-like growth factor binding protein (IGFBP) family (2011)
- Differential evolution of voltage-gated sodium channels in tetrapods and teleost fishes (2011)
- Evolution of vertebrate neuropeptide receptors (2010)
- Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates (2010)
- Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions (2010)
- Peripheral administration of pancreatic polypeptide inhibits components of food- intake behavior in dogs (2010)
- Perspective on Roseroot (Rhodiola rosea) Studies (2009)
- Steroid biosynthesis within the frog brain (2009)
- Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action (2009)
- Early duplications of opioid receptor and Peptide genes in vertebrate evolution (2009)
- Evolution of vertebrate rod and cone phototransduction genes (2009)
- Major genomic events and their consequences for vertebrate evolution and endocrinology (2009)
- Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation (2009)
- Evolution of the growth hormone-prolactin-somatolactin system in relation to vertebrate tetraploidizations (2009)
- Melanocortin peptides affect the motivation to feed in rainbow trout (Oncorhynchus mykiss) (2009)
- Evolution of vertebrate opioid receptors (2008)
- Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions (2008)
- Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization (2008)
- Evolution of the neuropeptide Y family (2008)
- Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters (2008)
- Peptide hormone and receptor evolution (2007)
- Cloning and sequence analysis of the neuropeptide Y receptors Y5 and Y6 in the coelacanth Latimeria chalumnae (2007)
- Neuropeptide Y-family receptors Y6 and Y7 in chicken (2006)
- Uneven Evolutionary Rates of Bradykinin B1 and B2 Receptors in Vertebrate Lineages (2006)
- Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss (2006)
- Pharmacological characterization of ligand-receptor interactions at the zebrafish bradykinin receptor (2005)
- Sensed presence and mystical experiences are predicted by suggestibility, not by the application of weak complex transcranial magnetic fields (2005)
- Reply to M.A. Persinger and S. A. Koren’s letter to the editor. Neuroscience Letters. (2005)
- Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes (2004)
- Localization of neuropeptide Y receptor Y5 mRNA in the guinea pig brain (2004)
- [Blood group diet (2004)
- Site-directed mutagenesis of the 5-HT1B receptor increases the affinity of 5-HT for the agonist low-affinity conformation and reduces the intrinsic acitivity of 5-HT. (2001)
- Mutagenesis of the human 5-HT1B receptor (1998)
- Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5
- Transducin duplicates in the zebrafish retina and pineal complex
- Evolution and expression of phosphodiesterase 6 genes show vertebrate novelty in the control of photosensitivity
- The vertebrate ancestral repertoire of five visual opsins was established in the two rounds of early vertebrate genome doublings
- Evolution of the growth hormone (GH), prolactin (PRL) and somatolactin (SL) family
- The growth hormone receptor (GHR) and prolactin receptor (PRLR) gene family expanded in the basal teleost tetraploidization
Kapitel
- Ancestral vertebrate complexity of the opioid system (2015)
- Mystikens neurobiologi och helandets mystik (2013)
- Evolution of the opioid system. (2013)
- Neuropeptide phylogeny and evolution (2009)
- Neuropeptide Y, evolution of (2004)
Övrigt
